| Name | Hoxb 1 |
|---|---|
| Synonyms | HOX B1; HOX 2; HOX2; HOX2I; HOXB 1; HOXB1; Homeo box 2I; Homeobox B1… |
| Name | EXD |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7600572 | Popperl H, Bienz M, Studer M, Chan SK, Aparicio S, Brenner S, Mann RS, Krumlauf R: Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx. Cell. 1995 Jun 30;81(7):1031-42. This provides in vivo and in vitro evidence that r4 expression involves direct autoregulation dependent on cooperative interactions of Hoxb-1 with exd/pbx proteins as cofactors. |
150(1,3,4,5) | Details |
| 9482740 | Berthelsen J, Zappavigna V, Ferretti E, Mavilio F, Blasi F: The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity. EMBO J. 1998 Mar 2;17(5):1434-45. The products of the mammalian Pbx and Drosophila exd genes are able to interact with Hox proteins specifically and to increase their DNA binding affinity and selectivity. Indeed, we observe the formation of a ternary Prep1-Pbx1-HOXB1 complex on a HOXB1-responsive target in vitro. |
2(0,0,0,2) | Details |
| 8665855 | Chan SK, Popperl H, Krumlauf R, Mann RS: An extradenticle-induced conformational change in a HOX protein overcomes an inhibitory function of the conserved hexapeptide motif. EMBO J. 1996 May 15;15(10):2476-87. The homeoprotein encoded by the extradenticle (exd) gene can selectively modify HOX DNA binding, suggesting that it contributes to HOX specificity in vivo. Here, we demonstrate that a 20 bp oligonucleotide from the 5' region of the mouse Hoxb-1 gene, a homolog of Drosophila labial (lab), is sufficient to direct an expression pattern in Drosophila that is very similar to endogenous lab. |
1(0,0,0,1) | Details |