Protein Information

Name PS7
Synonyms PS7; bitter taste receptor Ps7 pseudogene; bitter taste receptor Ps7 pseudogenes

Compound Information

Name EXD
CAS

Reference List

PubMed Abstract RScore(About this table)
7859741 Sun B, Hursh DA, Jackson D, Beachy PA: Ultrabithorax protein is necessary but not sufficient for full activation of decapentaplegic expression in the visceral mesoderm. EMBO J. 1995 Feb 1;14(3):520-35.

The exd protein binds in a highly co-operative manner to regulatory sequences mediating PS7-specific dpp expression, consistent with a genetic requirement for exd function in normal visceral mesoderm expression of dpp.
82(1,1,1,2) Details
16403493 Stultz BG, Jackson DG, Mortin MA, Yang X, Beachy PA, Hursh DA: Transcriptional activation by extradenticle in the Drosophila visceral mesoderm. Dev Biol. 2006 Feb 15;290(2):482-94. Epub 2006 Jan 3.

decapentaplegic (dpp) is a direct target of Ultrabithorax (Ubx) in parasegment 7 (PS7) of the embryonic visceral mesoderm.
We demonstrate that extradenticle (exd) and homothorax (hth) are also required for dpp expression in this location, as well as in PS3, at the site of the developing gastric caecae.
1(0,0,0,1) Details
7914871 Rauskolb C, Wieschaus E: Coordinate regulation of downstream genes by extradenticle and the homeotic selector proteins. EMBO J. 1994 Aug 1;13(15):3561-9.


Mutations in the Drosophila gene extradenticle (exd), a homologue of the human proto-oncogene pbx1, cause homeotic transformations by altering the morphological consequences of homeotic selector gene activity. exd has been proposed to act by contributing to the specificity of selector homeodomain proteins for their downstream targets.
0(0,0,0,0) Details