Protein Information

Name superoxide dismutase
Synonyms IPO B; Indophenoloxidase B; MNSOD; Manganese superoxide dismutase; Manganese containing superoxide dismutase; Mangano superoxide dismutase; Mn superoxide dismutase; Mn SOD…

Compound Information

Name atrazine
CAS

Reference List

PubMed Abstract RScore(About this table)
18092879 Qian H, Daniel Sheng G, Liu W, Lu Y, Liu Z, Fu Z: Inhibitory effects of atrazine on Chlorella vulgaris as assessed by real-time polymerase chain reaction. Environ Toxicol Chem. 2008 Jan;27(1):182-7.

The activities of antioxidation enzymes (e.g., superoxide dismutase, peroxidase, and catalase) also increased markedly in the presence of atrazine, with maximum increases of 1.82-, 1.59-, and 2.31-fold, respectively.
6(0,0,1,1) Details
19125545 Song Y, Zhu LS, Xie H, Wang J, Wang JH, Liu W, Dong XL: Effects of atrazine on DNA damage and antioxidative enzymes in Vicia faba. Environ Toxicol Chem. 2009 May;28(5):1059-62.

To evaluate atrazine (2-chloro-4-ethylamino-6-isopropylamino-1,3,5-triazine) ecotoxicology in soil, the effect of atrazine on the activity of antioxidative enzymes (superoxide dismutase [SOD], catalase [CAT], and guaiacol peroxidase [POD]) was investigated in Vicia faba roots.
6(0,0,1,1) Details
20138743 Singh M, Sandhir R, Kiran R: Effects on antioxidant status of liver following atrazine exposure and its attenuation by vitamin E. Exp Toxicol Pathol. 2010 Feb 6.

The activities of antioxidant enzymes: superoxide dismutase, catalase, glutathione peroxidase and glutathione-s-transferase were significantly increased following atrazine administration and vitamin E treatment could restore these activities.
6(0,0,1,1) Details
20136348 Singh M, Sandhir R, Kiran R: Oxidative stress induced by atrazine in rat erythrocytes: mitigating effect of vitamin E. Toxicol Mech Methods. 2010 Mar;20(3):119-26.

The activities of antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, and glutathione-s-transferase were found to be increased significantly in the erythrocytes accompanied by a decrease in the activity of the glucose-6-phosophate dehydrogenase, following atrazine exposure.
6(0,0,1,1) Details
20083397 Adesiyan AC, Oyejola TO, Abarikwu SO, Oyeyemi MO, Farombi EO: Selenium provides protection to the liver but not the reproductive organs in an atrazine-model of experimental toxicity. Exp Toxicol Pathol. 2010 Jan 16.

Superoxide dismutase decreased in the liver and testis but was increased in the epididymis.
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19778091 Lasserre JP, Fack F, Revets D, Planchon S, Renaut J, Hoffmann L, Gutleb AC, Muller CP, Bohn T: Effects of the endocrine disruptors atrazine and PCB 153 on the protein expression of MCF-7 human cells. J Proteome Res. 2009 Dec;8(12):5485-96.

Affected proteins included those regulating oxidative stress such as superoxide dismutase and structural proteins such as actin or tropomyosin, which may explain morphological changes of cells already observed under the microscope.
1(0,0,0,1) Details
16397785 Sulmon C, Gouesbet G, Amrani AE, Couee I: Sugar-induced tolerance to the herbicide atrazine in Arabidopsis seedlings involves activation of oxidative and xenobiotic stress responses. Plant Cell Rep. 2006 May;25(5):489-98. Epub 2006 Jan 6.

Sucrose-induced acquisition of defence mechanisms was shown by the gene expression pattern of a chloroplastic iron superoxide dismutase and by enhancement of whole-cell glucose-6-phosphate dehydrogenase activity.
1(0,0,0,1) Details
14961354 Downs CA, Fauth JE, Woodley CM: Assessing the health of grass shrimp (Palaeomonetes pugio) exposed to natural and anthropogenic stressors: a molecular biomarker system. Mar Biotechnol. 2001 Jul;3(4):380-97.

We developed a molecular biomarker system (MBS) to assess the physiological status of Palaomenetes pugio (grass shrimp) challenged with exposure to heat stress, cadmium, atrazine, and the water-accommodating fraction of either diesel fuel or bunker fuel No. 2.
The MBS assayed 9 specific cellular parameters of shrimp that are indicative of a nonstressed or stressed condition: heat-shock protein 60, heat-shock protein 70, alpha B-crystallin homologue, lipid peroxide, total glutathione level, ubiquitin, mitochondrial manganese superoxide dismutase, metallothionein, and cytochrome P-450 2E homologue.
1(0,0,0,1) Details
19672647 Abarikwu SO, Adesiyan AC, Oyeloja TO, Oyeyemi MO, Farombi EO: Changes in Sperm Characteristics and Induction of Oxidative Stress in the Testis and Epididymis of Experimental Rats by a Herbicide, Atrazine. Arch Environ Contam Toxicol. 2009 Aug 12.

In comparison to control, glutathione (GSH) and glutathione-S-transferase (GST) activities were elevated in the high-dose group, whereas the activity of superoxide dismutase (SOD), catalase (CAT); ascorbate (AA), and malondialdehyde (MDA) levels and hydrogen peroxide production were unchanged in the testis during the 7-day-exposure protocol.
1(0,0,0,1) Details
16777423 Nemat Alla MM, Hassan NM: Changes of antioxidants levels in two maize lines following atrazine treatments. Plant Physiol Biochem. 2006 Apr;44(4):202-10. Epub 2006 Jun 5.

Meanwhile, ascorbic acid (AsA) and reduced glutathione (GSH) contents were significantly decreased along with significant inhibitions in activities of superoxide dismutase (SOD; EC 1.15.1.1), catalase (CAT; EC 1.11.1.6), ascorbate peroxidase (APX; EC 1.11.1.7), guaiacol peroxidase (GPX; EC 1.11.1.7), and glutathione-S-transferase (GST; EC 2.5.1.18).
1(0,0,0,1) Details
20036412 Jin Y, Zhang X, Shu L, Chen L, Sun L, Qian H, Liu W, Fu Z: Oxidative stress response and gene expression with atrazine exposure in adult female zebrafish (Danio rerio). Chemosphere. 2010 Feb;78(7):846-52. Epub 2009 Dec 29.

Antioxidant enzyme activities (SOD and CAT), in addition to the GSH and MDA content, in the liver altered significantly; the mRNA levels for the genes encoding these antioxidant proteins, such as Cu/Zn-Sod, Mn-Sod, Cat, and Gpx, were up-regulated significantly in the liver when zebrafish were exposed to various concentrations of ATZ for 14d.
1(0,0,0,1) Details
19297032 Qian H, Chen W, Li J, Wang J, Zhou Z, Liu W, Fu Z: The effect of exogenous nitric oxide on alleviating herbicide damage in Chlorella vulgaris. Aquat Toxicol. 2009 May 17;92(4):250-7. Epub 2009 Feb 27.

Atrazine (100 microg/L) or glufosinate (10 mg/L) treatment alone or in combination with 20 microM sodium nitroprussiate (SNP, 10 microM with glufosinate) was administered to algae for a short time period of 48 h to observe changes in physiology and gene transcription and expression.
Supplementation also increased chlorophyll content and antioxidant enzymes, superoxide dismutase (SOD), peroxidase (POD) and catalase (CAT) activity, as compared to herbicide treatment alone.
1(0,0,0,1) Details
20020863 Mu H, Zhang P, Xu J: Testicular toxicity and mechanisms of chlorotoluron compounds in the mouse. Toxicol Mech Methods. 2008;18(5):399-403.

The effects of chlorotoluron and atrazine ingestion on male mouse reproductive function during the peripubertal period are reported here.
After mice were sacrificed, superoxide dismutase activity in blood was measured, weight ratios of testis to body were calculated, and testis tissues were examined by light and transmission electron microscopy.
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