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Pruett SB, Fan R, Oppenheimer S: Greater than additive suppression of TLR3-induced IL-6 responses by administration of dieldrin and atrazine. J Immunotoxicol. 2006 Dec 1;3(4):253-62.
However, at lower dosages of both compounds (10 mg/kg dieldrin and 50 mg/kg atrazine), the effect was much greater than additive on IL-6 production (adding the individual effects of atrazine and dieldrin on IL-6 production indicates 20% suppression, whereas the combination yields 80% suppression) and essentially additive for inhibition of the activation of c-JUN (a component of the transcription factor, AP-1). |
31(0,1,1,1) |
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