| Name | estrogen receptors |
|---|---|
| Synonyms | ER; ERA; ER alpha; ERalpha; ESR; ESR 1; ESR1; ESRA… |
| Name | atrazine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19079715 | Albanito L, Lappano R, Madeo A, Chimento A, Prossnitz ER, Cappello AR, Dolce V, Abonante S, Pezzi V, Maggiolini M: G-protein-coupled receptor 30 and estrogen receptor-alpha are involved in the proliferative effects induced by atrazine in ovarian cancer cells. Environ Health Perspect. 2008 Dec;116(12):1648-55. Epub 2008 Jul 22. BACKGROUND: Atrazine, one of the most common pesticide contaminants, has been shown to up-regulate aromatase activity in certain -sensitive tumors without binding or activating the estrogen receptor (ER). |
118(1,2,3,3) | Details |
| 15056801 | McMullin TS, Andersen ME, Nagahara A, Lund TD, Pak T, Handa RJ, Hanneman WH: Evidence that atrazine and diaminochlorotriazine inhibit the / induced surge of luteinizing hormone in female Sprague-Dawley rats without changing estrogen receptor action. Toxicol Sci. 2004 Jun;79(2):278-86. Epub 2004 Mar 31. |
82(1,1,1,2) | Details |
| 15081833 | Gale WL, Patino R, Maule AG: Interaction of xenobiotics with estrogen receptors alpha and beta and a putative plasma sex hormone-binding globulin from channel catfish (Ictalurus punctatus). Gen Comp Endocrinol. 2004 May 1;136(3):338-45. The alkylphenolic compounds (4-octylphenol and 4-nonylphenol) displayed some ability to displace 3H-E2 binding from ERalpha and beta at high concentrations, but dieldrin and atrazine had little binding activity for both ER subtypes and endosulfan for ERbeta. |
34(0,1,1,4) | Details |
| 19025096 | Eldridge JC, Stevens JT, Breckenridge CB: Atrazine interaction with expression systems. Rev Environ Contam Toxicol. 2008;196:147-60. More than 40 publications have described results of atrazine responses in 17 -dependent systems and in more than a dozen different reporter and estrogen receptor-binding studies in vitro. |
31(0,1,1,1) | Details |
| 14751673 | Yamasaki K, Sawaki M, Noda S, Muroi T, Takakura S, Mitoma H, Sakamoto S, Nakai M, Yakabe Y: Comparison of the Hershberger assay and androgen receptor binding assay of twelve chemicals. Toxicology. 2004 Feb 15;195(2-3):177-86. di-n-hexyl ester, di-n-amyl ester, and di-n-propyl ester are phthalates; diethylstilbestrol and 17beta- are estrogenic chemicals; tamoxifen is partial estrogen receptor antagonist with mainly estrogenic properties; is an androgen derivatives; dichlorodiphenyldichloroethane is a reference androgen antagonistic chemical; cyproterone acetate, 6alpha-methyl-17alpha-- and spironolactone have an androgenic steroid structure and are known as androgen antagonistic chemicals; and atrazine is a reference endocrine disruptor. |
31(0,1,1,1) | Details |
| 15183528 | Tanaka T, Kohno H, Suzuki R, Sugie S: Lack of modifying effects of an estrogenic compound atrazine on 7,12-dimethylbenz (a) anthracene-induced ovarian carcinogenesis in rats. Cancer Lett. 2004 Jul 16;210(2):129-37. We also assessed the effect of atrazine on proliferating cell nuclear antigen (PCNA)-index and the expression of estrogen receptor (ER)-alpha and -beta and androgen receptor (AR) in induced neoplasms. |
6(0,0,1,1) | Details |
| 10492897 | Balaguer P, Francois F, Comunale F, Fenet H, Boussioux AM, Pons M, Nicolas JC, Casellas C: Reporter cell lines to study the estrogenic effects of xenoestrogens. Sci Total Environ. 1999 Aug 15;233(1-3):47-56. MCF-7 cells which express the endogenous estrogen receptor alpha (ER alpha) were stably transfected with only an -regulated luciferase gene. In all of the models, nonylphenol mixture (NPm), 4n-nonylphenol (4nNP), 2,4'-DDE, 4,4'-DDE and wastewater sewage treatment effluent were active, while PCB mixture (Aroclor 1254), PCB 77, atrazine and lindane (gamma hexachlorocyclohexane) were inactive. |
3(0,0,0,3) | Details |
| 9171990 | Danzo BJ: Environmental xenobiotics may disrupt normal endocrine function by interfering with the binding of physiological ligands to steroid receptors and binding proteins. Environ Health Perspect. 1997 Mar;105(3):294-301. To determine whether xenobiotics (present at a concentration of 100 microM) exert their action through steroid-mediated pathways, we examined their ability to inhibit the binding of [3H] physiological ligands (present at a concentration of 7 nM) to the androgen and estrogen receptors, rat androgen-binding protein (ABP), and human sex hormone-binding globulin (hSHBG). The gamma- and delta-isomers of hexachlorocyclohexane, congeners of dichlorodiphenyl-trichloroethane (DDT; p,p'-DDT; p,p'-DDE; o,p'-DDT), dieldrin, atrazine, and pentachlorophenol, caused a statistically significant inhibition of specific binding of [3H] 5 alpha-DHT to the androgen receptor that ranged from 100% (p,p'-DDE) to 25% (dieldrin). |
2(0,0,0,2) | Details |
| 17088055 | Thomas P, Dong J: Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruption. J Steroid Biochem Mol Biol. 2006 Dec;102(1-5):175-9. Epub 2006 Nov 7. Kepone, p,p'-DDT, 2,2',5',-PCB-4-OH and o,p'-DDE had lower affinities with RBAs of 0.25-1.3%, whereas o,p'-DDT, p,p'-DDE, methoxychlor and atrazine caused less than 50% displacement of [(3) H]-E2 at concentrations up to 10 microM. |
2(0,0,0,2) | Details |
| 7932849 | Tennant MK, Hill DS, Eldridge JC, Wetzel LT, Breckenridge CB, Stevens JT: Chloro-s-triazine antagonism of action: limited interaction with estrogen receptor binding. J Toxicol Environ Health. 1994 Oct;43(2):197-211. In an accompanying article (see pp. 183-196), it was reported that administration of very high doses of the chlorotriazine herbicides atrazine, simazine, and diaminochlorotriazine (DACT), a common metabolite, expressed antiestrogenic activity in uteri of female Sprague-Dawley rats without expressing intrinsic estrogenic activity. |
2(0,0,0,2) | Details |
| 8858116 | Tran DQ, Kow KY, McLachlan JA, Arnold SF: The inhibition of estrogen receptor-mediated responses by chloro-S-triazine-derived compounds is dependent on concentration in yeast. Biochem Biophys Res Commun. 1996 Oct 3;227(1):140-6. The chloro-S-triazine derived compounds atrazine, atrazine desisopropyl, cyanazine, and simazine are commonly used herbicides. |
2(0,0,0,2) | Details |
| 19186820 | Zhang ZB, Hu JY, Sai SX, Zhao YB, Huang C, Tian XJ: [Gene cloning, sequence analysis and tissue expression of estrogen-related receptor alpha (Erralpha) in Japanese medaka and its transcriptional responses after differential EDCs exposure]. Huan Jing Ke Xue. 2008 Nov;29(11):3153-8. After 3 weeks exposure of medaka to 200 ng/L (EE2), 200 ng/L (E1), 200 ng/L diethylstilbestrol (DES), 100 microg/L atrazine (AT) and 200 ng/L 17beta- (E2), transcripts of ERRalpha were significantly decreased to 0.54, 0.56, 0.61, 0.63 and 0.65 of control (p < 0.05) in the testes, respectively. The DBD of medaka ERRalpha is of the same length and has high sequence identity with those of estrogen receptor (ERalpha and ERbeta) and androgen receptor (ARalpha and ARbeta) of medaka, but much difference was found between the LBD of medaka ERRalpha with those of ERalpha, ERbeta, ARalpha and ARbeta. |
1(0,0,0,1) | Details |
| 8812239 | Connor K, Howell J, Chen I, Liu H, Berhane K, Sciarretta C, Safe S, Zacharewski T: Failure of chloro-S-triazine-derived compounds to induce estrogen receptor-mediated responses in vivo and in vitro. Fundam Appl Toxicol. 1996 Mar;30(1):93-101. The potential estrogenic activities of atrazine and simazine were investigated in vivo using the immature female Sprague-Dawley rat uterus and in vitro using the -responsive MCF-7 human breast cancer cell line and the -dependent recombinant yeast strain PL3. |
1(0,0,0,1) | Details |
| 9118873 | Vonier PM, Crain DA, McLachlan JA, Guillette LJ Jr, Arnold SF: Interaction of environmental chemicals with the and progesterone receptors from the oviduct of the American alligator. Environ Health Perspect. 1996 Dec;104(12):1318-22. To determine whether environmental chemicals had the potential to function as exogenous hormones in the American alligator, we examined the ability of chemicals to bind the estrogen receptor (aER) and progesterone receptor (aPR) in a protein extract prepared from the oviduct of the alligator. Modern-use chemicals such as alachlor, trans-nonachlor, endosulfan, and atrazine also competed with [3H] 17 beta- for binding to the aER. |
1(0,0,0,1) | Details |
| 8723035 | Balaguer P, Joyeux A, Denison MS, Vincent R, Gillesby BE, Zacharewski T: Assessing the estrogenic and dioxin-like activities of chemicals and complex mixtures using in vitro recombinant receptor-reporter gene assays. Can J Physiol Pharmacol. 1996 Feb;74(2):216-22. The environmental (E2) bioassay consists of a Gal4-human estrogen receptor chimeric construct (Gal4-HEGO) and a Gal4-regulated luciferase reporter gene (17m5-G-Luc) that have been stably integrated into HeLa cells. These assays were used to assess the and dioxin-like activities of atrazine, and simazine and complex mixtures such as pulp and paper mill black liquor and urban air particulates. |
1(0,0,0,1) | Details |
| 12109482 | Legler J, Dennekamp M, Vethaak AD, Brouwer A, Koeman JH, van der Burg B, Murk AJ: Detection of estrogenic activity in sediment-associated compounds using in vitro reporter gene assays. Sci Total Environ. 2002 Jul 3;293(1-3):69-83. The organochlorine herbicides atrazine and simazine failed to induce reporter gene activity. Sediment-associated estrogenic potency was measured with an estrogen receptor-mediated luciferase reporter gene (ER-CALUX) assay and compared with a recombinant yeast screen. |
1(0,0,0,1) | Details |
| 18973769 | Salaberria I, Hansen BH, Asensio V, Olsvik PA, Andersen RA, Jenssen BM: Effects of atrazine on hepatic metabolism and endocrine homeostasis in rainbow trout (Oncorhynchus mykiss). Toxicol Appl Pharmacol. 2009 Jan 1;234(1):98-106. Epub 2008 Oct 10. Exhibiting negligible interaction with the estrogen receptor (ER), ATZ's mode of action remains to be elucidated. |
1(0,0,0,1) | Details |
| 17190974 | Moon HJ, Han SY, Shin JH, Kang IH, Kim TS, Hong JH, Kim SH, Fenton SE: Gestational exposure to nonylphenol causes precocious mammary gland development in female rat offspring. J Reprod Dev. 2007 Apr;53(2):333-44. Epub 2006 Dec 27. Time pregnant Long Evans rats were gavaged with NP (10 or 100 mg/kg), atrazine (ATR, 100 mg/kg), or corn oil on gestation days 15-19. Immunohistochemical comparisons of the mammary sections from PND 41 demonstrated low levels of estrogen receptor (ER) staining in the control gland stroma and epithelium but higher levels in the tissue of the pups exposed to NP and ATR. |
1(0,0,0,1) | Details |
| 10647908 | Hanioka N, Jinno H, Tanaka-Kagawa T, Nishimura T, Ando M: In vitro metabolism of simazine, atrazine and propazine by hepatic cytochrome P450 enzymes of rat, mouse and guinea pig, and oestrogenic activity of chlorotriazines and their main metabolites. Xenobiotica. 1999 Dec;29(12):1213-26. The binding affinity of chlorotriazines (SIZ, ATZ and PRZ) and their metabolites (M1-4) for recombinant human oestrogen receptor-alpha was assayed using the fluorescence polarization method. |
1(0,0,0,1) | Details |
| 11839478 | Hock B, Seifert M, Kramer K: Engineering receptors and antibodies for biosensors. Biosens Bioelectron. 2002 Mar;17(3):239-49. An enzyme linked immunosorbent assay (ELISA) was achieved for atrazine with an IC (50) of 0.9 microg l (-1) and a detection limit of 0.2 microg l (-1). For this purpose, the human estrogen receptor alpha was used. |
1(0,0,0,1) | Details |
| 11675267 | Sanderson JT, Letcher RJ, Heneweer M, Giesy JP, van den Berg M: Effects of chloro-s-triazine herbicides and metabolites on aromatase activity in various human cell lines and on vitellogenin production in male carp hepatocytes. Environ Health Perspect. 2001 Oct;109(10):1027-31. We determined effects on human aromatase (CYP19), the enzyme that converts androgens to estrogens, in H295R (adrenocortical carcinoma), JEG-3 (placental choriocarcinoma), and MCF-7 (breast cancer) cells; we determined effects on estrogen receptor-mediated induction of vitellogenin in primary hepatocyte cultures of adult male carp (Cyprinus carpio). In addition to atrazine, simazine, and propazine, two metabolites--atrazine-desethyl and atrazine-desisopropyl--induced aromatase activity in H295R cells concentration-dependently (0.3-30 microM) and with potencies similar to those of the parent triazines. |
1(0,0,0,1) | Details |
| 15649250 | Ueda M, Imai T, Takizawa T, Onodera H, Mitsumori K, Matsui T, Hirose M: Possible enhancing effects of atrazine on growth of 7,12-dimethylbenz (a) anthracene-induced mammary tumors in ovariectomized Sprague-Dawley rats. Cancer Sci. 2005 Jan;96(1):19-25. |
0(0,0,0,0) | Details |
| 19478717 | Roy JR, Chakraborty S, Chakraborty TR: -like endocrine disrupting chemicals affecting puberty in humans--a review. Med Sci Monit. 2009 Jun;15(6):RA137-45. The structural similarity of disruptors with allow them to bind and activate estrogen receptors and show a similar response even in the absence of that can lead to precocious puberty (PP). Major EEDCs found abundantly in our environment include; dichlorodiphenyltrichloroethane (DDT), dioxin, polychlorinated biphenyls (PCBs), bisphenol A (BPA), polybrominated biphenyls (PBB), esters, endosulfan, atrazine and zeranol. |
1(0,0,0,1) | Details |
| 11071396 | O'Connor JC, Plowchalk DR, Van Pelt CS, Davis LG, Cook JC: Role of prolactin in chloro-S-triazine rat mammary tumorigenesis. . Drug Chem Toxicol. 2000 Nov;23(4):575-601. Chloro-S-triazine herbicides [cyanazine (CZ), atrazine (AZ), simazine (SZ)] increase mammary tumors in Crl:CD BR rats but not in F-344 rats or in mice. In addition, AZ, CZ, and SZ were tested in several other in vitro models /biogenic amine receptor competition assays and a yeast-expressed human estrogen receptor transcription assay) as well as an in vivo 24 h time-course experiment to characterize the CZ-induced increases in PRL levels. |
1(0,0,0,1) | Details |
| 18585445 | Cimino-Reale G, Ferrario D, Casati B, Brustio R, Diodovich C, Collotta A, Vahter M, Gribaldo L: Combined in utero and juvenile exposure of mice to arsenate and atrazine in drinking water modulates gene expression and clonogenicity of myeloid progenitors. Toxicol Lett. 2008 Jul 30;180(1):59-66. Epub 2008 Jun 8. The expression of estrogen receptors alpha (ERalpha) and beta (ERbeta) in bone marrow cells was investigated, and an up-regulation of receptor beta was observed in both genders. |
1(0,0,0,1) | Details |
| 15655806 | Gammon DW, Aldous CN, Carr WC Jr, Sanborn JR, Pfeifer KF: A risk assessment of atrazine use in California: human health and ecological aspects. Pest Manag Sci. 2005 Apr;61(4):331-55. The mechanism for tumor development may include one or more of the following: the induction of aromatase (CYP19) and/or other P450 oxygenases, an antagonist action at the feedback receptor in the hypothalamus, an agonist action at the mammary gland estrogen receptor or an effect on adrenergic neurons in the hypothalamic-pituitary pathway. |
1(0,0,0,1) | Details |
| 15475179 | Roberge M, Hakk H, Larsen G: Atrazine is a competitive inhibitor of phosphodiesterase but does not affect the estrogen receptor. Toxicol Lett. 2004 Dec 1;154(1-2):61-8. |
0(0,0,0,0) | Details |