| Name | CYP1A1 |
|---|---|
| Synonyms | AHH; AHRR; Arylhydrocarbon hydroxylase; CP11; CYP 1; CYP1; CYP1A1; CYPIA 1… |
| Name | atrazine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16248553 | Kawahigashi H, Hirose S, Ohkawa H, Ohkawa Y: Transgenic rice plants expressing human CYP1A1 remediate the triazine herbicides atrazine and simazine. J Agric Food Chem. 2005 Nov 2;53(22):8557-64. Although transgenic and nontransgenic plants metabolized the two herbicides into the same sets of compounds, CYP1A1 plants metabolized atrazine and simazine more rapidly than did control plants. |
112(1,1,6,7) | Details |
| 14727741 | Bode M, Stobe P, Thiede B, Schuphan I, Schmidt B: Biotransformation of atrazine in transgenic tobacco cell culture expressing human P450. Pest Manag Sci. 2004 Jan;60(1):49-58. The results showed that both foreign enzymes CYP1A1 and CYP1A2 catalyse N-dealkylation of atrazine. |
83(1,1,1,3) | Details |
| 16608219 | Kawahigashi H, Hirose S, Ohkawa H, Ohkawa Y: Phytoremediation of the herbicides atrazine and metolachlor by transgenic rice plants expressing human CYP1A1, CYP2B6, and CYP2C19. J Agric Food Chem. 2006 Apr 19;54(8):2985-91. |
7(0,0,1,2) | Details |
| 11129571 | Shiota N, Kodama S, Inui H, Ohkawa H: Expression of human cytochromes P450 1A1 and P450 1A2 as fused enzymes with yeast -cytochrome P450 oxidoreductase in transgenic tobacco plants. Biosci Biotechnol Biochem. 2000 Oct;64(10):2025-33. Among 11 isoforms of the human cytochrome P450 enzymes metabolizing xenobiotics, CYP 1A1 and CYP 1A2 were major P450 species in the metabolism of the herbicides chlortoluron and atrazine in a yeast expression system. CYP1A2 was more active in the metabolism of both herbicides than CYP1A1. |
4(0,0,0,4) | Details |
| 12582499 | Yamada T, Ishige T, Shiota N, Inui H, Ohkawa H, Ohkawa Y: Enhancement of metabolizing herbicides in young tubers of transgenic potato plants with the rat CYP1A1 gene. Theor Appl Genet. 2002 Sep;105(4):515-520. Epub 2002 Jun 21. The residual herbicides, atrazine and chlortoluron, were analyzed in the micro-tubers of Ag2197 and non-transgenic plants. |
3(0,0,0,3) | Details |
| 10222312 | Hanioka N, Jinno H, Tanaka-Kagawa T, Nishimura T, Ando M: In vitro metabolism of chlorotriazines: characterization of simazine, atrazine, and propazine metabolism using liver microsomes from rats treated with various cytochrome P450 inducers. Toxicol Appl Pharmacol. 1999 May 1;156(3):195-205. The formation rates of SIZ-M1, ATZ-M1, ATZ-M2, and PRZ-M2 were significantly correlated with 7-ethoxyresorufin O-deethylase, acetanilide 4-hydroxylase, 7-ethoxycoumarin O-deethylase, 2-hydroxylase, and 7alpha-hydroxylase activities and CYP1A1/2 level, whereas the formation rates of ATZ-M3 and PRZ-M4 were significantly correlated with 16beta-hydroxylase, bufuralol 1'-hydroxylase, and 2-hydroxylase activities and CYP2B1/2 level. |
2(0,0,0,2) | Details |
| 20183062 | Abass K, Turpeinen M, Pelkonen O: An evaluation of the cytochrome P450 inhibition potential of selected pesticides in human hepatic microsomes. J Environ Sci Health B. 2009 Aug;44(6):553-63. The goal of this work was to study the ability of 18 pesticides to inhibit selective model activities for all major xenobiotic-metabolizing enzymes, namely CYP1A1/2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1 and 3A4. Some pesticides caused relatively potent inhibitions sporadically (carbendazim, CYP2D6, IC (50) = 12 micro M; atrazine, CYP3A4, IC (50) = 2.8 micro M; CYP2C9, IC (50) = 3.7 micro M; hexaflumuron, IC (50) = 6.0 micro M). |
2(0,0,0,2) | Details |
| 18214934 | Liedtke A, Muncke J, Rufenacht K, Eggen RI: Molecular multi-effect screening of environmental pollutants using the MolDarT. Environ Toxicol. 2008 Feb;23(1):59-67. The eggs were exposed for 120 hpf to the environmental pollutants (E2), ethinylestradiol (EE2), nonylphenol (NP), atrazine, cyproconazol, and bisphenol A (BPA) and found differential expression of the three genes. The genes metallothionein 2 (mt2), cytochrome P450 1A1 (cyp1a1), and recombination activation gene 1 (rag1) are used as endpoints that describe detoxification/metal toxicity (mt2), detoxification/PAH toxicity (cyp1a1), and acquired immune system disruption (rag1). |
2(0,0,0,2) | Details |
| 18685273 | Kawahigashi H, Hirose S, Ohkawa H, Ohkawa Y: Transgenic rice plants expressing human p450 genes involved in xenobiotic metabolism for phytoremediation. J Mol Microbiol Biotechnol. 2008;15(2-3):212-9. Epub 2008 Jul 28. Rice (Oryza sativa) is a good candidate for this purpose and has been transformed with genes encoding cytochrome P450 monooxygenases CYP1A1, CYP2B6, and CYP2C19. Transgenic plants were able to remove atrazine and metolachlor from soil. |
1(0,0,0,1) | Details |
| 11678611 | Tchounwou PB, Wilson BA, Ishaque AB, Schneider J: Atrazine potentiation of arsenic trioxide-induced cytotoxicity and gene expression in human liver carcinoma cells (HepG2). Mol Cell Biochem. 2001 Jun;222(1-2):49-59. |
0(0,0,0,0) | Details |