| Name | SF 1 |
|---|---|
| Synonyms | AD4BP; Adrenal 4 binding protein; ELP; FTZ 1; FTZ1; FTZF 1; FTZF1; Fushi tarazu factor homolog 1… |
| Name | atrazine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17520059 | Fan W, Yanase T, Morinaga H, Gondo S, Okabe T, Nomura M, Komatsu T, Morohashi K, Hayes TB, Takayanagi R, Nawata H: Atrazine-induced aromatase expression is SF-1 dependent: implications for endocrine disruption in wildlife and reproductive cancers in humans. Environ Health Perspect. 2007 May;115(5):720-7. Epub 2007 Feb 5. We used a luciferase reporter driven by the SF-1-dependent aromatase promoter (ArPII) to examine activation of this promoter by atrazine and the related simazine. |
349(4,4,8,9) | Details |
| 17331471 | Fan W, Yanase T, Morinaga H, Gondo S, Okabe T, Nomura M, Hayes TB, Takayanagi R, Nawata H: Herbicide atrazine activates SF-1 by direct affinity and concomitant co-activators recruitments to induce aromatase expression via promoter II. Biochem Biophys Res Commun. 2007 Apr 20;355(4):1012-8. Epub 2007 Feb 22. |
182(2,2,5,7) | Details |
| 18461179 | Suzawa M, Ingraham HA: The herbicide atrazine activates endocrine gene networks via non-steroidal NR5A nuclear receptors in fish and mammalian cells. PLoS One. 2008 May 7;3(5):e2117. ATR selectively increased zcyp19a1, a known gene target of the nuclear receptor SF-1 (NR5A1), whereas zcyp19a2, which is responsive, remained unchanged. |
4(0,0,0,4) | Details |
| 19541795 | Pogrmic K, Fa S, Dakic V, Kaisarevic S, Kovacevic R: Atrazine oral exposure of peripubertal male rats downregulates steroidogenesis gene expression in Leydig cells. Toxicol Sci. 2009 Sep;111(1):189-97. Epub 2009 Jun 18. Leydig cells from treated rats were characterised by significant decline in mRNA transcripts of several genes responsible for steroidogenesis: luteinizing hormone receptor (LHR), scavenger receptor-B1, steroidogenic acute regulatory protein, translocator protein, steroidogenic factor-1, phosphodiesterase 4B, 3beta-hydroxysteroid dehydrogenase (HSD), CYP17A1, and 17betaHSD. |
1(0,0,0,1) | Details |