Protein Information

Name hemoglobin (protein family or complex)
Synonyms Hemoglobin; Hemoglobins

Compound Information

Name atrazine
CAS

Reference List

PubMed Abstract RScore(About this table)
12825238 McMullin TS, Brzezicki JM, Cranmer BK, Tessari JD, Andersen ME: Pharmacokinetic modeling of disposition and time-course studies with [14C] atrazine. J Toxicol Environ Health A. 2003 May 23;66(10):941-64.

Absorption of radioactivity into plasma was slow with a rate constant of 0.2 h-1. 14C-disposition data indicated that CI-TRIs react with red blood cells (presumably hemoglobin) and plasma proteins.
2(0,0,0,2) Details
11345452 Allran JW, Karasov WH: Effects of atrazine on embryos, larvae, and adults of anuran amphibians. Environ Toxicol Chem. 2001 Apr;20(4):769-75.

0(0,0,0,0) Details
17567052 Dooley GP, Hanneman WH, Carbone DL, Legare ME, Andersen ME, Tessari JD: Development of an immunochemical detection method for atrazine-induced albumin adducts. Chem Res Toxicol. 2007 Jul;20(7):1061-6. Epub 2007 Jun 13.

Previously, we have reported that diaminochlorotriazine (DACT), an atrazine metabolite, forms a covalent adduct with rat hemoglobin at Cys-125.
81(1,1,1,1) Details
16854968 Rider CV, LeBlanc GA: Atrazine stimulates hemoglobin accumulation in Daphnia magna: is it hormonal or hypoxic?. Toxicol Sci. 2006 Oct;93(2):443-9. Epub 2006 Jul 19.

This hypothesis was tested by modeling the combined effects of atrazine and the terpenoid hormone mimic pyriproxyfen on hemoglobin mRNA levels assuming the same mechanism of action (concentration addition model) and alternatively, assuming different mechanisms of action (response addition model).
77(0,2,4,7) Details
18083243 Anderson TD, Jin-Clark Y, Begum K, Starkey SR, Zhu KY: Gene expression profiling reveals decreased expression of two hemoglobin genes associated with increased consumption of oxygen in Chironomus tentans exposed to atrazine: a possible mechanism for adapting to oxygen deficiency. Aquat Toxicol. 2008 Jan 31;86(2):148-56. Epub 2007 Nov 9.
38(0,1,2,3) Details
16696572 Dooley GP, Prenni JE, Prentiss PL, Cranmer BK, Andersen ME, Tessari JD: Identification of a novel hemoglobin adduct in Sprague Dawley rats exposed to atrazine. Chem Res Toxicol. 2006 May;19(5):692-700.
12(0,0,2,2) Details