| Name | superoxide dismutase |
|---|---|
| Synonyms | IPO B; Indophenoloxidase B; MNSOD; Manganese superoxide dismutase; Manganese containing superoxide dismutase; Mangano superoxide dismutase; Mn superoxide dismutase; Mn SOD… |
| Name | amitrole |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
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| 8845916 | Burdon RH, Gill V, Alliangana D: peroxide in relation to proliferation and apoptosis in BHK-21 hamster fibroblasts. Free Radic Res. 1996 Feb;24(2):81-93. Other agents such as inhibitors of peroxidase and catalase, or mimics of superoxide dismutase, which also bring about elevated cellular levels of H2O2 in BHK-21 cells, similarly lead to decreased proliferation and an apparent increase in cells with apoptopic features. |
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| 12775721 | Chovolou Y, Watjen W, Kampkotter A, Kahl R: Resistance to tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis in rat hepatoma cells expressing TNF-alpha is linked to low antioxidant enzyme expression. J Biol Chem. 2003 Aug 8;278(32):29626-32. Epub 2003 May 29. Expression of and zinc containing superoxide dismutase was also decreased, whereas expression of glutathione peroxidase-1 was unchanged in Yv2-12 and Yv13-44 cells. |
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| 2846684 | Ogino K, Oka S, Okazaki Y, Takemoto T: Gastric mucosal protection and superoxide dismutase. . J Clin Gastroenterol. 1988;10 Suppl 1:S129-32. |
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| 19607981 | Amantea D, Marrone MC, Nistico R, Federici M, Bagetta G, Bernardi G, Mercuri NB: Oxidative stress in stroke pathophysiology validation of peroxide metabolism as a pharmacological target to afford neuroprotection. Int Rev Neurobiol. 2009;85:363-74. is converted by superoxide dismutase into peroxide (H2O2), and the latter is then transformed into the toxic through the Haber-Weiss reaction, converted to water by peroxidase (GPx) or dismuted to water and through catalase. |
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| 17110013 | Orozco-Ibarra M, Medina-Campos ON, Sanchez-Gonzalez DJ, Martinez-Martinez CM, Floriano-Sanchez E, Santamaria A, Ramirez V, Bobadilla NA, Pedraza-Chaverri J: Evaluation of oxidative stress in induced nephrotoxicity. Toxicology. 2007 Jan 5;229(1-2):123-35. Epub 2006 Oct 20. The activity of antioxidant enzymes catalase, superoxide dismutase, peroxidase, and glutathione reductase remained unchanged at all times studied. |
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| 17206381 | Yang ES, Park JW: Antioxidant enzyme inhibitors enhance -induced cell death in U937 cells. Mol Cell Biochem. 2007 Jul;301(1-2):61-8. Epub 2007 Jan 6. The protective role of antioxidant enzymes against -induced oxidative damage in U937 cells was investigated in control and cells pre-treated with diethyldithiocarbamic acid, aminotriazole, and oxlalomalate, specific inhibitors of superoxide dismutase, catalase, and (+)-dependent isocitrate dehydrogenase, respectively. |
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| 9381482 | Kanthasamy AG, Ardelt B, Malave A, Mills EM, Powley TL, Borowitz JL, Isom GE: Reactive species generated by mediate toxicity in rat pheochromocytoma cells. Toxicol Lett. 1997 Sep 19;93(1):47-54. Also antioxidant defense enzymes (CuZn superoxide dismutase and especially catalase) in PC12 cells are inhibited by |
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| 12123625 | Srivastava P, Rajanikanth M, Raghavan SA, Dikshit M: Role of endogenous reactive derived species and cyclooxygenase mediators in -induced contractions in rat aorta: relationship to Pharmacol Res. 2002 May;45(5):375-82. Pretreatment of the rings with superoxide dismutase scavenger), catalase (H (2) O (2) inactivator), (extracellular OH. scavenger), or thiourea (intracellular OH. radical scavenger) significantly depressed the -induced contractions in the aortic rings. |
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| 9199892 | Hanada H, Kashiwagi A, Takehara Y, Kanno T, Yabuki M, Sasaki J, Inoue M, Utsumi K: Do reactive species underlie the mechanism of apoptosis in the tadpole tail?. Free Radic Biol Med. 1997;23(2):294-301. During the apoptotic changes, the activity of Cu/Zn-type superoxide dismutase (SOD) in the tail markedly increased with a concomitant decrease in its catalase activity. |
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| 10457996 | Oliiarnyk OD, Velykyi MM, Makhnevych TR: [Features of the inhibition of catalase activity by 3-amino-1,2,4-triazole in erythrocytes and liver of rats with streptozotocin diabetes]. Ukr Biokhim Zh. 1999 Jan-Feb;71(1):77-82. Activity of antioxidant enzyme superoxide-dismutase was decreased, activity of catalase was increased. |
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| 17387509 | Yu Y, Zhong MK, Li J, Sun XL, Xie GQ, Wang W, Zhu GQ: Endogenous peroxide in paraventricular nucleus mediating cardiac sympathetic afferent reflex and regulating sympathetic activity. Pflugers Arch. 2007 Jul;454(4):551-7. Epub 2007 Mar 27. Bilateral microinjection of polyethylene glycol-catalase (PEG-CAT, an analogue of endogenous catalase) or polyethylene glycol-superoxide dismutase (PEG-SOD, an analogue of endogenous superoxide dismutase) into the PVN abolished the CSAR, decreased baseline RSNA and mean arterial pressure (MAP). |
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| 2648406 | Brown JM, Grosso MA, Terada LS, Whitman GJ, Banerjee A, White CW, Harken AH, Repine JE: Endotoxin pretreatment increases endogenous myocardial catalase activity and decreases ischemia-reperfusion injury of isolated rat hearts. Proc Natl Acad Sci U S A. 1989 Apr;86(7):2516-20. Hearts isolated from rats pretreated 24 hr before with endotoxin had increased myocardial catalase activity, but the same superoxide dismutase, peroxidase, glutathione reductase, and glucose-6-phosphate dehydrogenase activities, as hearts from untreated rats. |
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| 2903826 | Michiels C, Remacle J: Use of the inhibition of enzymatic antioxidant systems in order to evaluate their physiological importance. Eur J Biochem. 1988 Nov 1;177(2):435-41. Inhibition values were obtained for catalase with aminotriazole, for superoxide dismutase with diethyldithiocarbamate, for peroxidase with mercaptosuccinate, for glutathione reductase with bischloroethylnitrosourea and for synthesis with buthionine sulfoximine. |
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| 7581830 | Burdon RH, Alliangana D, Gill V: peroxide and the proliferation of BHK-21 cells. Free Radic Res. 1995 Nov;23(5):471-86. Other agents which also diminish the growth-associated decline in intracellular levels of H2O2, such as the superoxide dismutase mimic, II-(3,5-diisopropylsalicylate) 2, or also reduced cell proliferation. |
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| 208649 | Bhuyan KC, Bhuyan DK: Superoxide dismutase of the eye: relative functions of superoxide dismutase and catalase in protecting the ocular lens from oxidative damage. Biochim Biophys Acta. 1978 Aug 3;542(1):28-38. |
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| 16910777 | Dasgupta J, Subbaram S, Connor KM, Rodriguez AM, Tirosh O, Beckman JS, Jourd'Heuil D, Melendez JA: Manganese superoxide dismutase protects from TNF-alpha-induced apoptosis by increasing the steady-state production of H2O2. Antioxid Redox Signal. 2006 Jul-Aug;8(7-8):1295-305. |
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| 420858 | McMahon S, Stern A: The interrelationship of superoxide dismutase and peroxidatic enzymes in the red cell. Biochim Biophys Acta. 1979 Feb 9;566(2):253-8. |
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| 12611279 | Zheng QS, Zhang YT, Zheng RL: induces redifferentiation and growth inhibition in human hepatoma cells by increasing endogenous peroxide. Pharmazie. 2002 Nov;57(11):753-7. After treatment with AA, the content of peroxide (H2O2) and the activity of superoxide dismutase (SOD) increased in a concentration- and time-dependent manner, while the activity of catalase (CAT) decreased in a concentration- and time-dependent manner. |
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| 7946385 | Kinnula VL, Yankaskas JR, Chang L, Virtanen I, Linnala A, Kang BH, Crapo JD: Primary and immortalized (BEAS 2B) human bronchial epithelial cells have significant antioxidative capacity in vitro. Am J Respir Cell Mol Biol. 1994 Nov;11(5):568-76. Immunocytochemical studies showed a similar pattern of intracellular localization with the moderate degrees of labeling for Mn superoxide dismutase (SOD), CuZn SOD, and catalase in freshly isolated bronchial epithelial cells, bronchial epithelial cells in primary culture, and BEAS 2B cells. |
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| 4040372 | Ribiere C, Sinaceur J, Nordmann J, Nordmann R: Discrepancy between the different subcellular activities of rat liver catalase and superoxide dismutases in response to acute administration. Alcohol Alcohol. 1985;20(1):13-8. |
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| 1560230 | Przedborski S, Jackson-Lewis V, Kostic V, Carlson E, Epstein CJ, Cadet JL: Superoxide dismutase, catalase, and peroxidase activities in /zinc-superoxide dismutase transgenic mice. J Neurochem. 1992 May;58(5):1760-7. |
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| 7527573 | Van den Branden C, Vamecq J, Verbeelen D, Roels F: In vivo peroxide production in rat remnant kidney. . Ren Physiol Biochem. 1994 Sep-Oct;17(5):240-5. The activities of the peroxisomal H2O2-producing oxidases, D-amino acid oxidase and acyl- oxidase, and of the extraperoxisomal superoxide dismutase are decreased in renal homogenate. |
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| 4051505 | Tu YY, Yang CS: Demethylation and denitrosation of nitrosamines by cytochrome P-450 isozymes. Arch Biochem Biophys. 1985 Oct;242(1):32-40. Involvement of radicals in the metabolism of NDMA was suggested by the action of superoxide dismutase, which inhibited the denitrosation by 43 to 73% and the demethylation by 13 to 22% in different monooxygenase systems. |
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| 1962528 | Ohmori T, Ogata M: Methemoglobin formation by ferrocyanide in the hemolysate of acatalasemic mice. Acta Med Okayama. 1991 Aug;45(4):209-15. The addition of catalase reduced the metHb level, while superoxide dismutase (SOD) had little effect on it. |
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| 3029209 | Turrens JF, Giulivi C, Boveris A: Increased spontaneous chemiluminescence from liver homogenates and isolated hepatocytes upon inhibition of O2- and H2O2 utilization. J Free Radic Biol Med. 1986;2(2):135-40. The intracellular steady-state concentrations of peroxide or were increased by inhibiting either catalase, peroxidase, or superoxide dismutase activities. |
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| 10762670 | Karasu C: Time course of changes in endothelium-dependent and -independent relaxation of chronically diabetic aorta: role of reactive species. Eur J Pharmacol. 2000 Mar 31;392(3):163-73. In the presence of diethyldithiocarbamate (5 mM), an inhibitor of superoxide dismutase, the transient nature of the relaxant response to or sodium nitroprusside was more marked and the peak relaxations were inhibited; these effects of diethyldithiocarbamate were more pronounced in diabetic than in control rings. |
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| 11874445 | Kocak G, Karasu C: Elimination of *O (2)(-)/H (2) O (2) by mediates the recovery of basal EDRF/NO availability and the reversal of superoxide dismutase-induced relaxation in diabetic rat aorta. Diabetes Obes Metab. 2002 Jan;4(1):69-74. AIM: The aims of this study were to ascertain the mechanism (s) of relaxant action of exogenous superoxide dismutase (SOD) in aortic rings obtained from 12-week, streptozotocin (STZ)-diabetic and age-matched control rats, and to examine the effects of (ALA) treatment (for 6 weeks, after 6 weeks of untreated diabetes) on SOD-induced relaxations. |
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| 18945933 | Wu L, Zhang Z, Zhang H, Wang XC, Huang R: Transcriptional modulation of ethylene response factor protein JERF3 in the oxidative stress response enhances tolerance of tobacco seedlings to salt, drought, and freezing. Plant Physiol. 2008 Dec;148(4):1953-63. Epub 2008 Oct 22. More importantly, this regulation of the expression of oxidative genes subsequently enhances the activities of superoxide dismutase but reduces the content of ROS in tobacco under drought, cold, salt, and abscisic acid treatments. |
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| 9225743 | Brown DR, Schulz-Schaeffer WJ, Schmidt B, Kretzschmar HA: Prion protein-deficient cells show altered response to oxidative stress due to decreased SOD-1 activity. Exp Neurol. 1997 Jul;146(1):104-12. In vivo studies show that the activity of Cu/Zn superoxide dismutase is reduced in Prnp gene-ablated (Prnp0/0) mice. |
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| 1847583 | Mugge A, Elwell JH, Peterson TE, Harrison DG: Release of intact endothelium-derived relaxing factor depends on endothelial superoxide dismutase activity. Am J Physiol. 1991 Feb;260(2 Pt 1):C219-25. |
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| 11283936 | Kahlos K, Soini Y, Sormunen R, Kaarteenaho-Wiik R, Paakko P, Linnainmaa K, Kinnula VL: Expression and prognostic significance of catalase in malignant mesothelioma. Cancer. 2001 Apr 1;91(7):1349-57. Malignant mesothelioma is a resistant tumor with high levels of manganese superoxide dismutase, a central scavenging AOE. |
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| 3013154 | Kerckaert I, Roels F: Myocardial H2O2 production in the unanaesthetized rat. Basic Res Cardiol. 1986 Jan-Feb;81(1):83-91. Influence of fasting, myocardial load and inhibition of superoxide dismutase and monoamine oxidase.. |
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| 9721600 | Rastogi L, Patnaik GK, Dikshit M: Free radicals and antioxidant status following pylorus ligation induced gastric mucosal injury in rats. Pharmacol Res. 1998 Aug;38(2):125-32. While a significant and time-dependent decrease in the content, superoxide dismutase and peroxidase activity was observed after pyloric ligation. |
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| 15907765 | Kashiwagi K, Shinkai T, Kajii E, Kashiwagi A: The effects of reactive species on amphibian aging. Comp Biochem Physiol C Toxicol Pharmacol. 2005 Feb;140(2):197-205. Superoxide dismutase (SOD), catalase, and peroxidase (GPx) activity in 10-year-old liver decreased 40-80% from 3-year-old liver levels. |
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| 3000027 | Johnson JD, Isom GE: The oxidative disposition of in mice. Toxicology. 1985 Dec;37(3-4):215-24. However, superoxide dismutase significantly increased the amount of 14CO2 expired, whereas diethyldithiocarbamic acid decreased 14CO2 expiration. |
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| 14962975 | Carter AB, Tephly LA, Venkataraman S, Oberley LW, Zhang Y, Buettner GR, Spitz DR, Hunninghake GW: High levels of catalase and peroxidase activity dampen H2O2 signaling in human alveolar macrophages. Am J Respir Cell Mol Biol. 2004 Jul;31(1):43-53. Epub 2004 Feb 12. Increasing the steady-state levels of H2O2 by using polyethylene glycol superoxide dismutase, an antioxidant that crosses the cell membrane, or aminotriazole, an irreversible inhibitor of catalase, allowed the p38 MAP kinase to be activated in alveolar macrophages. |
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| 16136055 | Nie H, Xiong L, Lao N, Chen S, Xu N, Zhu Z: Hyperbaric preconditioning induces tolerance against spinal cord ischemia by upregulation of antioxidant enzymes in rabbits. J Cereb Blood Flow Metab. 2006 May;26(5):666-74. Activities of catalase (CAT) and superoxide dismutase were increased in spinal cord tissue in the HBO group 24 h after the last pretreatment and reached a higher level after spinal cord ischemia for 20 mins followed by reperfusion for 24 or 48 h, in comparison with those in control and HBA groups. |
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| 6406261 | Nickla H, Anderson J, Palzkill T: Enzymes involved in detoxification during development of Drosophila melanogaster. Experientia. 1983 Jun 15;39(6):610-2. Activities of superoxide dismutase (SOD), catalase (CAT), and peroxidases (PER) were examined at 24-h intervals during Drosophila development. |
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| 7562957 | Cai Y, Appelkvist EL, DePierre JW: Hepatic oxidative stress and related defenses during treatment of mice with and other peroxisome proliferators. J Biochem Toxicol. 1995 Apr;10(2):87-94. Certain antioxidant enzymes (DT-diaphorase, superoxide dismutase, glutathione transferase, peroxidase, and glutathione reductase) and components and were also measured. |
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| 8279580 | Maitre B, Jornot L, Junod AF: Effects of inhibition of catalase and superoxide dismutase activity on antioxidant enzyme mRNA levels. Am J Physiol. 1993 Dec;265(6 Pt 1):L636-43. |
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| 11568965 | Paes MC, Oliveira MB, Oliveira PL: peroxide detoxification in the midgut of the blood-sucking insect, Rhodnius prolixus. Arch Insect Biochem Physiol. 2001 Oct;48(2):63-71. Superoxide dismutase (SOD) catalyzes the dismutation of (O2-). |
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| 2827016 | Sofuni T, Ishidate M Jr: Induction of chromosomal aberrations in active -generating systems. Mutat Res. 1988 Jan;197(1):127-32. The induction of chromosomal aberrations by PQ was enhanced by a 1-h pretreatment with diethyldithiocarbamate, an inhibitor of superoxide dismutase. |
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| 2162328 | Geffner JR, Minnucci F, Isturiz MA: Neutrophil-mediated cytotoxicity induced by secretory IgA. Immunol Lett. 1990 May;24(2):113-6. Catalase completely impaired this non-specific cytotoxicity (NSC), while superoxide dismutase (SOD) significantly enhanced it, suggesting a key role for peroxide (H2O2) in the lysis of target cells. |
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| 9731227 | Ghanam K, Javellaud J, Ea-Kim L, Oudart N: The protective effect of 17 on vasomotor responses of aorta from -fed rabbit is reduced by inhibitors of superoxide dismutase and catalase. Biochem Biophys Res Commun. 1998 Aug 28;249(3):858-64. |
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| 3445547 | Antonenkov VD, Gusev VA, Krasnova SN: [Effect of and the catalase inhibitor aminotriazole on the activity of antioxidative enzymes in the rat liver and heart]. Vopr Med Khim. 1987 Nov-Dec;33(6):59-64. Effect of and aminotriazole on content of as well as on activity of catalase, superoxide dismutase, glutathione-S-transferase and glucose-6-phosphate dehydrogenase, the enzymes participating in the antioxidation system, were also studied in liver and heart tissues. |
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| 7681805 | Zhang H, Agardh E, Agardh CD: Nitro blue tetrazolium staining: a morphological demonstration of in the rat retina. Graefes Arch Clin Exp Ophthalmol. 1993 Mar;231(3):178-83. To establish whether NBT could be useful in morphological demonstration of free radicals in the retina, the staining pattern was examined in normal rat retina and after incubation with the free radical scavenger superoxide dismutase or with inhibitors of free radical protective enzymes, such as dicoumarol, and aminotriazole. |
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| 19543301 | Guo HC, Zhang Z, Zhang LN, Xiong C, Feng C, Liu Q, Liu X, Shi XL, Wang YL: Chronic intermittent hypobaric hypoxia protects the heart against ischemia/reperfusion injury through upregulation of antioxidant enzymes in adult guinea pigs. Acta Pharmacol Sin. 2009 Jul;30(7):947-55. Epub 2009 Jun 22. The activity and protein expression of superoxide dismutase (SOD) and catalase (CAT) were significantly increased in the myocardium of CIHH guinea pigs. |
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| 10443915 | Karasu C: Increased activity of H2O2 in aorta isolated from chronically streptozotocin-diabetic rats: effects of antioxidant enzymes and enzymes inhibitors. Free Radic Biol Med. 1999 Jul;27(1-2):16-27. Decreased sensitivity (pD2) of diabetic vessels to vasorelaxant action of H2O2 was normalized by superoxide dismutase (SOD, 80 U/ml). |
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| 6282638 | Geerts A, Roels F: In vivo cooperation between hepatic catalase and superoxide dismutase demonstrated by diethyldithiocarbamate. FEBS Lett. 1982 Apr 19;140(2):245-7. |
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| 6661212 | Allen RG, Farmer KJ, Sohal RS: Effect of catalase inactivation on levels of inorganic peroxides, superoxide dismutase, consumption and life span in adult houseflies (Musca domestica). Biochem J. 1983 Nov 15;216(2):503-6. |
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| 3169364 | Antonenkov VD, Panchenko LF: Effect of chronic treatment under partial catalase inhibition on the activity of enzymes related to peroxide metabolism in rat liver and heart. Int J Biochem. 1988;20(8):823-8. In order to test the hypothesis that the alcoholic cardiomyopathy under partial catalase inhibition is associated with the activation of lipid peroxidation in cardiomyocytes (Panchenko et al., Experientia 43, 580-581, 1987), the effects of and catalase inhibitor 3-amino-1,2,4-triazole (aminotriazole) on rat heart and liver content of and on the activity of enzymes related to peroxide metabolism: catalase, superoxide dismutase, peroxidase, glutathione reductase, glutathione-S-transferase and glucose-6-phosphate dehydrogenase were investigated. 2. |
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| 14975711 | De Backer O, Colpaert EE, Lefebvre RA: Influence of polyethylene-glycol-superoxide dismutase and combined depletion and repletion of antioxidants on nitrergic relaxation in the pig gastric fundus. Eur J Pharmacol. 2004 Feb 20;486(2):223-32. |
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| 9612287 | Weissmann N, Grimminger F, Voswinckel R, Conzen J, Seeger W: Nitro blue tetrazolium inhibits but does not mimic hypoxic vasoconstriction in isolated rabbit lungs. Am J Physiol. 1998 May;274(5 Pt 1):L721-7. We probed this hypothesis in perfused rabbit lungs, employing the scavengers superoxide dismutase (SOD), 4,5-dihydroxy-1,3- disulfonic acid (Tiron), and nitro blue tetrazolium (NBT) and the catalase inhibitor aminotriazole (AT). |
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| 9140708 | Maenishi O, Ito H, Suzuki T: Acceleration of hypertensive cerebral injury by the inhibition of -xanthine oxidase system in stroke-prone spontaneously hypertensive rats. Clin Exp Hypertens. 1997 May;19(4):461-77. It is well-known that, in ischemic cerebral injury, a free radical and its byproducts are generated by -xanthine oxidase system and eliminated by scavengers such as superoxide dismutase (SOD), catalase, and |
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| 10389973 | Kahlos K, Pitkanen S, Hassinen I, Linnainmaa K, Kinnula VL: Generation of reactive species by human mesothelioma cells. Br J Cancer. 1999 Apr;80(1-2):25-31. Malignant mesothelioma cells contain elevated levels of manganese superoxide dismutase (MnSOD) and are highly resistant to oxidants compared to non-malignant mesothelial cells. |
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