| 12611279 |
Zheng QS, Zhang YT, Zheng RL: Ascorbic acid induces redifferentiation and growth inhibition in human hepatoma cells by increasing endogenous hydrogen peroxide. Pharmazie. 2002 Nov;57(11):753-7.
Using 6 mM AA as a positive control, after treatment by 50 microM hydrogen peroxide, the malignant characteristics of human hepatoma cells were alleviated; for example as cell surface charge markedly decreased, the electrophoresis rate dropped from 1.68 microns.s-1.V-1.cm-1 to 0.97, the average of alpha-fetoprotein content decreased from 327 micrograms.g-1 protein to 193, and gamma-glutamyl-transpeptidase activity fell from 0.84 U.g-1 protein to 0.30. |
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