| Name | glutathione reductase |
|---|---|
| Synonyms | GLUR; GR; GRD 1; GRD1; GRase; GSR; Glutathione reductase; GRases… |
| Name | amitrole |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7562957 | Cai Y, Appelkvist EL, DePierre JW: Hepatic oxidative stress and related defenses during treatment of mice with and other peroxisome proliferators. J Biochem Toxicol. 1995 Apr;10(2):87-94. Certain antioxidant enzymes (DT-diaphorase, superoxide dismutase, glutathione transferase, peroxidase, and glutathione reductase) and components and were also measured. |
1(0,0,0,1) | Details |
| 3421709 | Miccadei S, Kyle ME, Gilfor D, Farber JL: Toxic consequence of the abrupt depletion of in cultured rat hepatocytes. Arch Biochem Biophys. 1988 Sep;265(2):311-20. Inhibition of glutathione reductase by 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) or inhibition of catalase by aminotriazole sensitized the hepatocytes to the cytotoxicity of DNFB. |
1(0,0,0,1) | Details |
| 1733283 | Kinnula VL, Chang L, Everitt JI, Crapo JD: Oxidants and antioxidants in alveolar epithelial type II cells: in situ, freshly isolated, and cultured cells. Am J Physiol. 1992 Jan;262(1 Pt 1):L69-77. Biochemical studies showed that cell culture resulted in a significant decrease in activities of catalase (49%), glutathione reductase (50%), peroxidase (74%), and in the capacity of the cells to scavenge extracellular H2O2. |
1(0,0,0,1) | Details |
| 3965466 | Starke PE, Farber JL: Endogenous defenses against the cytotoxicity of peroxide in cultured rat hepatocytes. J Biol Chem. 1985 Jan 10;260(1):86-92. The catalase activity of cultured rat hepatocytes was inhibited by 90% pretreatment with 20 mM aminotriazole without effect on the activities of peroxidase or glutathione reductase, or on the viability of the cells over the subsequent 24 h. |
3(0,0,0,3) | Details |
| 8469024 | Perez-Campo R, Lopez-Torres M, Rojas C, Cadenas S, Barja de Quiroga G: Lung glutathione reductase induction in aging catalase-depleted frogs correlates with early survival throughout the life span. Mech Ageing Dev. 1993 Feb;67(1-2):115-27. |
3(0,0,0,3) | Details |
| 2488015 | Costarides A, Recasens JF, Riley MV, Green K: The effects of 3-aminotriazole, and 1,3-bis-(2-chloroethyl)-1-nitrosourea on peroxide levels in the rabbit aqueous humor. Lens Eye Toxic Res. 1989;6(1-2):167-73. BCNU (1,3-bis-(2-chloroethyl)-1-nitrosourea) was given intravitreally to rabbits: 3.0 mg suppressed iris glutathione reductase activity by 80%, but only increased the /total ratio to 26% from 18%. |
1(0,0,0,1) | Details |
| 9037247 | Renard P, Zachary MD, Bougelet C, Mirault ME, Haegeman G, Remacle J, Raes M: Effects of antioxidant enzyme modulations on interleukin-1-induced nuclear factor kappa B activation. Biochem Pharmacol. 1997 Jan 24;53(2):149-60. In this study, we systematically evaluated the influence of peroxidase, glutathione reductase and catalase on IL-1-induced NF-kappa B activation by analysing the effect of specific inhibitors of these enzymes. |
1(0,0,0,1) | Details |
| 2648406 | Brown JM, Grosso MA, Terada LS, Whitman GJ, Banerjee A, White CW, Harken AH, Repine JE: Endotoxin pretreatment increases endogenous myocardial catalase activity and decreases ischemia-reperfusion injury of isolated rat hearts. Proc Natl Acad Sci U S A. 1989 Apr;86(7):2516-20. Hearts isolated from rats pretreated 24 hr before with endotoxin had increased myocardial catalase activity, but the same superoxide dismutase, peroxidase, glutathione reductase, and glucose-6-phosphate dehydrogenase activities, as hearts from untreated rats. |
1(0,0,0,1) | Details |
| 2903826 | Michiels C, Remacle J: Use of the inhibition of enzymatic antioxidant systems in order to evaluate their physiological importance. Eur J Biochem. 1988 Nov 1;177(2):435-41. Inhibition values were obtained for catalase with aminotriazole, for superoxide dismutase with diethyldithiocarbamate, for peroxidase with mercaptosuccinate, for glutathione reductase with bischloroethylnitrosourea and for synthesis with buthionine sulfoximine. |
1(0,0,0,1) | Details |
| 8771766 | Nag AC, Sreepathi P, Lee ML, Reddan JR: Effect of oxidative insult on young and adult cardiac muscle cells in vitro. Cytobios. 1996;85(340):7-27. Microscopical studies suggested a more marked protection by catalase than by glutathione reductase in the neonatal cells. |
1(0,0,0,1) | Details |
| 7946385 | Kinnula VL, Yankaskas JR, Chang L, Virtanen I, Linnala A, Kang BH, Crapo JD: Primary and immortalized (BEAS 2B) human bronchial epithelial cells have significant antioxidative capacity in vitro. Am J Respir Cell Mol Biol. 1994 Nov;11(5):568-76. Biochemical analysis showed remarkably similar catalase and glutathione reductase activities in primary cultured epithelial cells and BEAS 2B cells.(ABSTRACT TRUNCATED AT 250 WORDS) |
1(0,0,0,1) | Details |
| 2100169 | Green K, Costarides AP, Riley MV: Role of in the regulation of anterior chamber peroxide. Lens Eye Toxic Res. 1990;7(3-4):419-26. BCNU (1,3-bis-(2-chloroethyl)-l-nitrosourea) and BSO (buthionine sulfoxamine) were used to suppress glutathione reductase and synthesis, respectively. |
1(0,0,0,1) | Details |
| 3169364 | Antonenkov VD, Panchenko LF: Effect of chronic treatment under partial catalase inhibition on the activity of enzymes related to peroxide metabolism in rat liver and heart. Int J Biochem. 1988;20(8):823-8. In order to test the hypothesis that the alcoholic cardiomyopathy under partial catalase inhibition is associated with the activation of lipid peroxidation in cardiomyocytes (Panchenko et al., Experientia 43, 580-581, 1987), the effects of and catalase inhibitor 3-amino-1,2,4-triazole (aminotriazole) on rat heart and liver content of and on the activity of enzymes related to peroxide metabolism: catalase, superoxide dismutase, peroxidase, glutathione reductase, glutathione-S-transferase and glucose-6-phosphate dehydrogenase were investigated. 2. |
1(0,0,0,1) | Details |
| 18457571 | Bayliak M, Gospodaryov D, Semchyshyn H, Lushchak V: Inhibition of catalase by aminotriazole in vivo results in reduction of glucose-6-phosphate dehydrogenase activity in Saccharomyces cerevisiae cells. Biochemistry. 2008 Apr;73(4):420-6. In vivo inhibition of catalase by AMT in S. cerevisiae caused a simultaneous decrease in glucose-6-phosphate dehydrogenase activity and an increase in glutathione reductase activity. |
1(0,0,0,1) | Details |
| 2624761 | Simon RH, DeHart PD, Nadeau DM: Resistance of rat pulmonary alveolar epithelial cells to neutrophil- and oxidant-induced injury. Am J Respir Cell Mol Biol. 1989 Sep;1(3):221-9. Partial inhibition of -dependent reactions by depleting intracellular with buthionine sulfoximine or by inhibiting the enzyme glutathione reductase with 1,3-bis (2-chloroethyl)-1-nitrosourea also augmented the cytotoxic effect of both H2O2 and stimulated neutrophils. |
1(0,0,0,1) | Details |
| 17110013 | Orozco-Ibarra M, Medina-Campos ON, Sanchez-Gonzalez DJ, Martinez-Martinez CM, Floriano-Sanchez E, Santamaria A, Ramirez V, Bobadilla NA, Pedraza-Chaverri J: Evaluation of oxidative stress in induced nephrotoxicity. Toxicology. 2007 Jan 5;229(1-2):123-35. Epub 2006 Oct 20. The activity of antioxidant enzymes catalase, superoxide dismutase, peroxidase, and glutathione reductase remained unchanged at all times studied. |
1(0,0,0,1) | Details |
| 16168691 | Bagnyukova TV, Storey KB, Lushchak VI: Adaptive response of antioxidant enzymes to catalase inhibition by aminotriazole in goldfish liver and kidney. Comp Biochem Physiol B Biochem Mol Biol. 2005 Nov;142(3):335-41. Epub 2005 Sep 15. peroxidase and glutathione-S-transferase activities increased in kidney after aminotriazole treatment whereas activities of peroxidase and glutathione reductase in liver decreased after 24 h but rebounded by 168 h. |
1(0,0,0,1) | Details |
| 8554348 | Przybytkowski E, Averill-Bates DA: Correlation between and stimulation of the cycle in situ in Chinese hamster ovary cells exposed to peroxide. Arch Biochem Biophys. 1996 Jan 1;325(1):91-8. The stimulatory effects of both oxidants on cycle activity appeared to be independent of glutathione reductase activity since they were unaffected in cells treated with 1,3-bis (2-chloroethyl)-1-nitrosourea. |
1(0,0,0,1) | Details |
| 10086993 | Hiraishi H, Shimada T, Ivey KJ, Terano A: Role of antioxidant defenses against -induced damage in cultured rat gastric epithelial cells. J Pharmacol Exp Ther. 1999 Apr;289(1):103-9. Incubation of cells with DL-buthionine-(S,R)-sulfoximine, while reducing production, dose dependently enhanced -induced injury. 1,3-Bis (chloroethyl)-nitrosourea, while inhibiting glutathione reductase activity, also sensitized cells to |
1(0,0,0,1) | Details |
| 8200258 | Ito Y, Suzuki Y, Ogonuki H, Hiraishi H, Razandi M, Terano A, Harada T, Ivey KJ: Role of iron and redox cycle in -induced cytotoxicity to cultured rat hepatocytes. Dig Dis Sci. 1994 Jun;39(6):1257-64. Pretreatment with both diethyl which covalently binds as catalyzed by glutathione-S-transferase, and bis (chloroethyl)-nitrosourea, an inhibitor of glutathione reductase, enhanced -induced cytotoxicity. |
1(0,0,0,1) | Details |
| 1784460 | Costarides AP, Riley MV, Green K: Roles of catalase and the redox cycle in the regulation of anterior-chamber peroxide. Ophthalmic Res. 1991;23(5):284-94. The effects of inhibition of both synthesis and of glutathione reductase and catalase activities have been determined in the regulation of peroxide (H2O2) in the anterior chamber of pigmented rabbits. |
1(0,0,0,1) | Details |