| Name | glutathione peroxidase 4 |
|---|---|
| Synonyms | GPX 4; MCSP; GPX4; GPX4 protein; Glutathione peroxidase 4; Glutathione peroxidase 4 (phospholipid hydroperoxidase); PHGPx; Phospholipid hydroperoxidase… |
| Name | diquat |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15496407 | Ran Q, Liang H, Gu M, Qi W, Walter CA, Roberts LJ 2nd, Herman B, Richardson A, Van Remmen H: Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis. J Biol Chem. 2004 Dec 31;279(53):55137-46. Epub 2004 Oct 20. Liver damage and lipid peroxidation induced by diquat were reduced significantly in Tg (GPX4) mice. |
122(1,2,3,7) | Details |
| 19447173 | Liang H, Ran Q, Jang YC, Holstein D, Lechleiter J, McDonald-Marsh T, Musatov A, Song W, Van Remmen H, Richardson A: Glutathione peroxidase 4 differentially regulates the release of apoptogenic proteins from mitochondria. Free Radic Biol Med. 2009 Aug 1;47(3):312-20. Epub 2009 May 15. In addition, diquat exposure induced peroxidation in the liver of Wt mice; the levels of peroxidation were reduced in Tg (GPX4 (+/0)) mice but elevated in Gpx4+/- mice. |
84(1,1,1,4) | Details |
| 19744930 | Liang H, Yoo SE, Na R, Walter CA, Richardson A, Ran Q: Short form glutathione peroxidase 4 is the essential isoform required for survival and somatic mitochondrial functions. J Biol Chem. 2009 Nov 6;284(45):30836-44. Epub 2009 Sep 10. Our results showed that transgenic mice with the sGPX4 gene had increased Gpx4 protein in all tissues and were protected against diquat-induced apoptosis in liver. |
12(0,0,1,7) | Details |
| 17395155 | Liang H, Van Remmen H, Frohlich V, Lechleiter J, Richardson A, Ran Q: Gpx4 protects mitochondrial ATP generation against oxidative damage. Biochem Biophys Res Commun. 2007 May 18;356(4):893-8. Epub 2007 Mar 21. Glutathione peroxidase 4 (Gpx4) is an antioxidant defense enzyme found in mitochondria as well as other subcellular organelles that directly detoxifies membrane lipid hydroperoxides. To determine if Gpx4 protects ATP production in vivo, we compared mitochondrial ATP production between wild-type mice and Gpx4 transgenic mice using a diquat model. |
1(0,0,0,1) | Details |