| 18445702 |
Han ES, Muller FL, Perez VI, Qi W, Liang H, Xi L, Fu C, Doyle E, Hickey M, Cornell J, Epstein CJ, Roberts LJ, Van Remmen H, Richardson A: The in vivo gene expression signature of oxidative stress. Physiol Genomics. 2008 Jun 12;34(1):112-26. Epub 2008 Apr 29.
The main finding of our study is that the common response to elevated oxidative stress with diquat treatment in wild-type, Gpx1 (-/-), and Sod1 (-/-) mice and in untreated Sod1 (-/-) mice is an upregulation of p53 target genes (p21, Gdf15, Plk3, Atf3, Trp53inp1, Ddit4, Gadd45a, Btg2, Ndrg1). |
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