| Name | superoxide dismutase |
|---|---|
| Synonyms | IPO B; Indophenoloxidase B; MNSOD; Manganese superoxide dismutase; Manganese containing superoxide dismutase; Mangano superoxide dismutase; Mn superoxide dismutase; Mn SOD… |
| Name | diquat |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1648014 | Bhuyan DK, Bhuyan KC: Oxy radicals in the eye tissues of rabbits after diquat in vivo. Free Radic Res Commun. 1991;12-13 Pt 2:621-7. We found that indirect spectrophotometric techniques based on superoxide dismutase (SOD)-inhibitable cytochrome c reduction for estimation of O2-., hydroxylation for OH. and peroxidase catalysed reoxidation of 2,6-dichlorophenolindophenol for H2O2, were suitable, sensitive and reproducible for measurements of the reactive species of O2 produced in the eye tissues by oxy radical enhancer, diquat in the rabbit eye in vivo. |
31(0,1,1,1) | Details |
| 18445702 | Han ES, Muller FL, Perez VI, Qi W, Liang H, Xi L, Fu C, Doyle E, Hickey M, Cornell J, Epstein CJ, Roberts LJ, Van Remmen H, Richardson A: The in vivo gene expression signature of oxidative stress. Physiol Genomics. 2008 Jun 12;34(1):112-26. Epub 2008 Apr 29. Therefore, we measured oxidative stress parameters and gene expression alterations (Affymetrix arrays) in the liver caused by elevated reactive species induced in vivo by diquat or by genetic ablation of the major antioxidant enzymes CuZn-superoxide dismutase (Sod1) and glutathione peroxidase-1 (Gpx1). |
6(0,0,1,1) | Details |
| 10490281 | Fu Y, Cheng WH, Porres JM, Ross DA, Lei XG: Knockout of cellular glutathione peroxidase gene renders mice susceptible to diquat-induced oxidative stress. Free Radic Biol Med. 1999 Sep;27(5-6):605-11. Responses of hepatic superoxide dismutase activities to the diquat treatment were affected by the GPX1 level. |
6(0,0,1,1) | Details |
| 2753390 | Monteiro HP, Vile GF, Winterbourn CC: Release of iron from ferritin by semiquinone, anthracycline, bipyridyl, and nitroaromatic radicals. Free Radic Biol Med. 1989;6(6):587-91. Ferritin iron was released by a number of bipyridyl radicals including those derived from diquat and paraquat, the anthracycline radicals of adriamycin, daunorubicin and epirubicin, the semiquinones of anthraquinone-2-sulphonate, 1,5 and 2,6-dihydroxyanthraquinone, 1-hydroxyanthraquinone, purpurin, and plumbagin, and the nitroaromatic radicals of nitrofurantoin and metronidazole. In air, iron release was inhibited by superoxide dismutase. |
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| 16097801 | Wallace MA, Bailey S, Fukuto JM, Valentine JS, Gralla EB: Induction of phenotypes resembling CuZn-superoxide dismutase deletion in wild-type yeast cells: an in vivo assay for the role of in the toxicity of redox-cycling compounds. Chem Res Toxicol. 2005 Aug;18(8):1279-86. We report that dioxygen sensitive phenotypes similar to those seen in sod1delta cells can be induced in wild-type cells by treatment with moderate concentrations of paraquat or diquat, another bipyridyl herbicide, providing strong evidence that the mechanism of toxicity for both of these compounds is attributable to stress. |
2(0,0,0,2) | Details |
| 20039174 | Fischer LR, Glass JD: Oxidative stress induced by loss of Cu,Zn-superoxide dismutase (SOD1) or -generating herbicides causes axonal degeneration in mouse DRG cultures. Acta Neuropathol. 2010 Feb;119(2):249-59. Epub 2009 Dec 29. To test susceptibility to increased production, we exposed wild-type DRGs to the redox-cycling herbicides paraquat and diquat (DQ). |
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| 321251 | Witschi H: Environmental agents altering lung biochemistry. Fed Proc. 1977 Apr;36(5):1631-4. The - peroxidase system affords protection against lipid peroxidation and increased activity of superoxide dismutase provides tolerance. Biochemical adaptation occasionally occurs very quickly: the herbicides paraquat and diquat produce an acute loss of cellular in lung. |
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| 1648013 | Bhuyan KC, Bhuyan DK, Podos SM: Free radical enhancer xenobiotic is an inducer of cataract in rabbit. Free Radic Res Commun. 1991;12-13 Pt 2:609-20. Free radical enhancers, diquat, paraquat, plumbagin and juglone were used to study the oxy radical-induced damage to the rabbit lens in vitro and in vivo. These peroxidative and oxidative changes were potentiated in the presence of 100% O2, abolished by N2 and prevented by desferal-Mn (III) (DF-Mn) or liposomal superoxide dismutase (LSOD) indicating the involvement of O2-. |
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| 3020022 | Thomas CE, Aust SD: Reductive release of iron from ferritin by cation free radicals of paraquat and other bipyridyls. J Biol Chem. 1986 Oct 5;261(28):13064-70. Aerobically, iron release was inhibited approximately 60% by superoxide dismutase, whereas xanthine oxidase-dependent iron release was inhibited nearly 100%. Similarly, the cation free radicals of the closely related chemicals, diquat and benzyl viologen, also promoted iron release. |
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| 10746947 | Gupta S, Husser RC, Geske RS, Welty SE, Smith CV: Sex differences in diquat-induced hepatic necrosis and DNA fragmentation in Fischer 344 rats. Toxicol Sci. 2000 Mar;54(1):203-11. Hepatic activities of superoxide dismutase (SOD) and peroxidase (GPX) were similar in the two genders, and activities of glutathione reductase (GR) and glutathione S-transferase-alpha (GST-alpha) activities were higher in the male rats. |
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| 20353071 | Zhou KJ, Guan CY, Xiao WN: [Effects of chemical ripeners on chlorophyll content and antioxidant enzyme activities of rapeseed pod]. Ying Yong Sheng Tai Xue Bao. 2009 Dec;20(12):3015-9. A field experiment was conducted to study the effects of ripeners Diguat and Roundup on the chlorophyll content, activities of catalase (CAT), superoxide dismutase (SOD), and peroxidase (POD), cell membrane permeability, and malondialdehyde (MDA) content of rapeseed pods. Under effects of Diquat, the chlorophyll content decreased, while the activities of SOD, POD, and CAT, cell membrane permeability, and MDA content increased significantly, leading to the peroxidation of membrane lipid. |
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| 20036301 | Lu T, Piao XL, Zhang Q, Wang D, Piao XS, Kim SW: Protective effects of Forsythia suspensa extract against oxidative stress induced by diquat in rats. Food Chem Toxicol. 2010 Feb;48(2):764-70. Epub 2009 Dec 28. Also, FSC significantly increased the activities of superoxide dismutase (SOD), peroxidase (GSH-Px), and the levels of (GSH) in plasma, liver and kidney whereas it decreased the levels of malondialdehyde (MDA) in plasma and kidney. |
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| 11814326 | Slaughter MR, Thakkar H, O'Brien PJ: Effect of diquat on the antioxidant system and cell growth in human neuroblastoma cells. Toxicol Appl Pharmacol. 2002 Jan 15;178(2):63-70. Viable cells were assayed for (GSH) and activities of catalase (CAT), superoxide dismutase (SOD), glutathione reductase (GR), peroxidase (GPX), and glucose-6-phosphate dehydrogenase (GPDH). |
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| 2855422 | Mira D, Brunk U, Boveris A, Cadenas E: One-electron transfer reactions of diquat radical to different reduction intermediates of Free Radic Biol Med. 1988;5(3):155-63. |
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| 1320687 | Rikans LE, Cai Y: Age-associated enhancement of diquat-induced lipid peroxidation and cytotoxicity in isolated rat hepatocytes. J Pharmacol Exp Ther. 1992 Jul;262(1):271-8. |
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| 669584 | Lengfelder E, Elstner EF: Determination of the dismutating activity of D-penicillamine Hoppe Seylers Z Physiol Chem. 1978 Jun;359(6):751-7. formation from by chloroplasts in the presence of diquat (1, 1'-dimethylene-2,2'-bipyridylium dibromide). |
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| 8240381 | Cornu MC, Moore GA, Nakagawa Y, Moldeus P: uptake by isolated rat hepatocytes. Biochem Pharmacol. 1993 Oct 19;46(8):1333-8. Stimulatory effect of diquat, a redox cycling compound.. |
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| 17616690 | Kim EH, Sohn S, Kwon HJ, Kim SU, Kim MJ, Lee SJ, Choi KS: selenite induces -mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells. Cancer Res. 2007 Jul 1;67(13):6314-24. Furthermore, treatment with diquat, a generator, induced autophagic cell death in glioma cells. |
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| 15496407 | Ran Q, Liang H, Gu M, Qi W, Walter CA, Roberts LJ 2nd, Herman B, Richardson A, Van Remmen H: Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis. J Biol Chem. 2004 Dec 31;279(53):55137-46. Epub 2004 Oct 20. Cell death induced by t-butylhydroperoxide and diquat was significantly less in murine embryonic fibroblasts from Tg (GPX4) mice compared with wild type mice. |
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| 7364936 | Burk RF, Lawrence RA, Lane JM: Liver necrosis and lipid peroxidation in the rat as the result of paraquat and diquat administration. J Clin Invest. 1980 May;65(5):1024-31. |
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| 2825600 | Sandy MS, Moldeus P, Ross D, Smith MT: Cytotoxicity of the redox cycling compound diquat in isolated hepatocytes: involvement of peroxide and transition metals. Arch Biochem Biophys. 1987 Nov 15;259(1):29-37. |
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| 16663782 | Lewinsohn E, Gressel J: Benzyl Viologen-Mediated Counteraction of Diquat and Paraquat Phytotoxicities. Plant Physiol. 1984 Sep;76(1):125-130. These included other bipyridinium compounds and derivatives, as well as compounds having similar or more positive redox potentials than paraquat and compounds known to increase or maintain high superoxide dismutase activity levels in plants.Only treatments with benzyl viologen, a benzyl analog of paraquat, protected Spirodela oligorrhiza (Kurz) Hegelm. colonies from otherwise damaging levels of diquat.NADP photoreduction by isolated thylakoids was inhibited by the same concentrations of paraquat, diquat, and benzyl viologen given separately. |
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| 7676460 | Gallagher EP, Buetler TM, Stapleton PL, Wang C, Stahl DL, Eaton DL: The effects of diquat and ciprofibrate on mRNA expression and catalytic activities of hepatic xenobiotic metabolizing and antioxidant enzymes in rat liver. Toxicol Appl Pharmacol. 1995 Sep;134(1):81-91. We examined the effects of diquat (0.1 mmol/kg, ip) and ciprofibrate (0.025% w/w, diet), chemicals which induce oxidative stress via different biochemical mechanisms, on the steady-state messenger RNA (mRNA) levels of six cytochrome P450 enzymes, seven glutathione S-transferase (GST) isoenzymes, UDP-glucuronosyl transferase 1-06 (UGT1*06), gamma-glutamylcysteine synthetase (gamma GCS), (H):quinone oxidoreductase (quinone reductase), Cu/Zn superoxide dismutase (SOD), catalase, and 18S ribosomal RNA in the livers of male Sprague-Dawley rats. |
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| 11672444 | Fu Y, Porres JM, Lei XG: Comparative impacts of glutathione peroxidase-1 gene knockout on oxidative stress induced by reactive and species in mouse hepatocytes. Biochem J. 2001 Nov 1;359(Pt 3):687-95. Our objective was to compare the protection of GPX1 against cytotoxicity of generator diquat (DQ), NO donor S-nitroso-N-acetyl-penicillamine (SNAP) and generator 3-morpholinosydnonimine (SIN-1). Decreases in Cu,Zn-superoxide dismutase (SOD) activity and increases in Mn-SOD activity in response to DQ or DQ+SNAP were greater in the KO cells than in the WT cells. |
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