Protein Information

Name CGRP
Synonyms Alpha type CGRP; CT; CGRP; CALC 1; CALC1; CALCA; CGRP 1; CGRP I…

Compound Information

Name chloralose
CAS

Reference List

PubMed Abstract RScore(About this table)
12805660 Edvinsson L, Goadsby PJ, Uddman R: Amylin: localization, effects on cerebral arteries and on local cerebral blood flow in the cat. ScientificWorldJournal. 2001 May 1;1:168-80.

In vivo studies of amylin, adrenomedullin, and CGRP showed a brisk reproducible increase in local cerebral blood flow as examined using laser Doppler flowmetry applied to the cerebral cortex of the alpha-chloralose-anesthetized cat.
14(0,0,1,9) Details
1415800 Okamoto H, Hoka S, Kawasaki T, Sato M, Yoshitake J: Effects of CGRP on baroreflex control of heart rate and renal sympathetic nerve activity in rabbits. Am J Physiol. 1992 Oct;263(4 Pt 2):R874-9.

We examined the effects of intravenous infusion of calcitonin gene-related peptide (CGRP) and sodium nitroprusside (SNP) on baroreceptor afferent nerve activity, renal sympathetic efferent nerve activity (RSNA), and heart rate in alpha-chloralose-anesthetized rabbits.
13(0,0,1,8) Details
12112942 Salem N, Dunbar JC: The insulin-mediated vascular and blood pressure responses are suppressed in CGRP-deficient normal and diabetic rats. Diabetes Metab Res Rev. 2002 May-Jun;18(3):238-44.

At 12-13 weeks the animals were fasted, anesthetized with chloralose/urethane and instrumented for recording of cardiovascular dynamics.
8(0,0,0,8) Details
12588046 McRae CR, Rao SP, Dunbar JC: Cardiovascular action of insulin-like growth factor-1 is not mediated by calcitonin gene-related peptide neurons. Endocrine. 2002 Nov;19(2):163-7.

Calcitonin gene-related peptide (CGRP) is a potent vasodilator located in the peripheral nerves including the perivascular nerves.
At this time rats were fasted overnight, anesthetized with urethane and chloralose, and prepared for cardiovascular recordings.
8(0,0,0,8) Details
8536296 Edvinsson L, Jansen Olesen I, Kingman TA, McCulloch J, Uddman R: Modification of vasoconstrictor responses in cerebral blood vessels by lesioning of the trigeminal nerve: possible involvement of CGRP. Cephalalgia. 1995 Oct;15(5):373-83.

The functional role of the trigeminal system has been addressed in experiments on the cortical surface of alpha-chloralose anaesthetized cats.
6(0,0,0,6) Details
1718570 Bereiter DA, Benetti AP: Microinjections of calcitonin gene-related peptide within the trigeminal subnucleus caudalis of the cat affects adrenal and autonomic function. Brain Res. 1991 Aug 30;558(1):53-62.

To assess the role of calcitonin gene-related peptide (CGRP) within the trigeminal subnucleus caudalis (Vc) on adrenal and autonomic function, microinjections were directed at different laminae of Vc in chloralose-anesthetized cats.
36(0,1,1,6) Details
8385759 Goadsby PJ: Inhibition of calcitonin gene-related peptide by h-CGRP (8-37) antagonizes the cerebral dilator response from nasociliary nerve stimulation in the cat. Neurosci Lett. 1993 Mar 5;151(1):13-6.

In this study, the CGRP antagonist h-CGRP (8-37) was examined for its ability to interfere with trigeminal-evoked cerebral vasodilator responses in the alpha-chloralose anaesthetised cat.
36(0,1,1,6) Details
15237097 Storer RJ, Akerman S, Goadsby PJ: Calcitonin gene-related peptide (CGRP) modulates nociceptive trigeminovascular transmission in the cat. Br J Pharmacol. 2004 Aug;142(7):1171-81. Epub 2004 Jul 5.

Cats were anaesthetised with alpha-chloralose, and using halothane during surgical preparation.
6(0,0,0,6) Details
12023327 Goadsby PJ, Hoskin KL, Storer RJ, Edvinsson L, Connor HE: Adenosine A1 receptor agonists inhibit trigeminovascular nociceptive transmission. Brain. 2002 Jun;125(Pt 6):1392-401.

Cats were anaesthetized (alpha-chloralose 60 mg/kg, intraperitoneally), and prepared for physiological monitoring.
Blood was sampled from the external jugular vein to determine levels of calcitonin gene-related peptide (CGRP) release before and after drug administration.
2(0,0,0,2) Details
7928323 Goadsby PJ, Edvinsson L: Joint 1994 Wolff Award Presentation. Headache. 1994 Jul-Aug;34(7):394-9.

It has been shown that certain peptides can act as markers for the trigeminal system, in particular calcitonin gene-related peptide (CGRP), and that CGRP is elevated in migraine.
Cats were anesthetized by halothane induction and alpha-chloralose maintenance (60 mg/kg, intraperitoneal), intubated, paralyzed and ventilated.
1(0,0,0,1) Details
9368576 Armstead WM: Brain injury impairs ATP-sensitive K+ channel function in piglet cerebral arteries. Stroke. 1997 Nov;28(11):2273-9; discussion 2280.

Similarly, FPI blunted dilation to calcitonin gene-related peptide, an endogenous KATP activator.
METHODS: Chloralose-anesthetized newborn pigs equipped with a closed cranial window were connected to a percussion device that consisted of a saline-filled cylindrical reservoir and a metal pendulum.
1(0,0,0,1) Details