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Nakagawa Y, Moldeus P, Cotgreave IA: The S-thiolation of hepatocellular protein thiols during diquat metabolism. Biochem Pharmacol. 1992 Jun 23;43(12):2519-25.
Although the identities of these species are uncertain (the 30-kDa protein may be equivalent to carbonic anhydrase as reported by Rokutan et al., Biochemistry 179: 233-239, 1989), it may be that oxidative modification of these proteins by stimulated S-glutathionylation may be an important early event in the mechanism of the hepatotoxicity of diquat. |
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