| Name | catalase |
|---|---|
| Synonyms | CAT; Catalase; Erythrocyte derived growth promoting factor; Carnitine O acetyltransferase; Carnitine acetylase; Carnitine acetyltransferase; CAT; Catalases… |
| Name | diquat |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9522278 | Blakeman DP, Ryan TP, Jolly RA, Petry TW: Protein oxidation: examination of potential lipid-independent mechanisms for protein carbonyl formation. J Biochem Mol Toxicol. 1998;12(3):185-90. This hypothesis was supported by the inhibitory effect of catalase on diquat-mediated protein carbonyl formation. |
31(0,1,1,1) | Details |
| 7676460 | Gallagher EP, Buetler TM, Stapleton PL, Wang C, Stahl DL, Eaton DL: The effects of diquat and ciprofibrate on mRNA expression and catalytic activities of hepatic xenobiotic metabolizing and antioxidant enzymes in rat liver. Toxicol Appl Pharmacol. 1995 Sep;134(1):81-91. We examined the effects of diquat (0.1 mmol/kg, ip) and ciprofibrate (0.025% w/w, diet), chemicals which induce oxidative stress via different biochemical mechanisms, on the steady-state messenger RNA (mRNA) levels of six cytochrome P450 enzymes, seven glutathione S-transferase (GST) isoenzymes, UDP-glucuronosyl transferase 1-06 (UGT1*06), gamma-glutamylcysteine synthetase (gamma GCS), (H):quinone oxidoreductase (quinone reductase), Cu/Zn superoxide dismutase (SOD), catalase, and 18S ribosomal RNA in the livers of male Sprague-Dawley rats. |
6(0,0,1,1) | Details |
| 2922765 | Boutin JA, Kass GE, Moldeus P: Drug-induced peroxide production in isolated rat hepatocytes. . Toxicology. 1989 Feb;54(2):129-37. A method for measuring drug-induced peroxide production in freshly isolated rat hepatocytes is described. 3-Amino-1,2,4-triazole, an irreversible inhibitor of the enzyme catalase markedly reduces the capacity of isolated hepatocytes to metabolize peroxide, with maximum inhibition (80%) being observed after 40 min of co-incubation. Using this assay we could demonstrate increased peroxide production during the metabolism of diquat, paraquat, benzylamine and by hepatocytes. |
2(0,0,0,2) | Details |
| 20353071 | Zhou KJ, Guan CY, Xiao WN: [Effects of chemical ripeners on chlorophyll content and antioxidant enzyme activities of rapeseed pod]. Ying Yong Sheng Tai Xue Bao. 2009 Dec;20(12):3015-9. A field experiment was conducted to study the effects of ripeners Diguat and Roundup on the chlorophyll content, activities of catalase (CAT), superoxide dismutase (SOD), and peroxidase (POD), cell membrane permeability, and malondialdehyde (MDA) content of rapeseed pods. Under effects of Diquat, the chlorophyll content decreased, while the activities of SOD, POD, and CAT, cell membrane permeability, and MDA content increased significantly, leading to the peroxidation of membrane lipid. |
1(0,0,0,1) | Details |
| 11814326 | Slaughter MR, Thakkar H, O'Brien PJ: Effect of diquat on the antioxidant system and cell growth in human neuroblastoma cells. Toxicol Appl Pharmacol. 2002 Jan 15;178(2):63-70. Viable cells were assayed for (GSH) and activities of catalase (CAT), superoxide dismutase (SOD), glutathione reductase (GR), peroxidase (GPX), and glucose-6-phosphate dehydrogenase (GPDH). |
1(0,0,0,1) | Details |
| 4386931 | Gage JC: The action of paraquat and diquat on the respiration of liver cell fractions. Biochem J. 1968 Oct;109(5):757-61. One molecule of can oxidize two molecules of in the stimulated microsomal system, the peroxide produced being broken down by a catalase activity in the microsomes. 5. |
1(0,0,0,1) | Details |
| 10564541 | Fu Y, Cheng WH, Ross DA, Lei X: Cellular glutathione peroxidase protects mice against lethal oxidative stress induced by various doses of diquat. Proc Soc Exp Biol Med. 1999 Nov;222(2):164-9. |
0(0,0,0,0) | Details |
| 7172099 | Wildeman AG, Nazar RN: Significance of plant metabolism in the mutagenicity and toxicity of pesticides. Can J Genet Cytol. 1982;24(4):437-49. The study indicates that plant metabolism can alter the results of this short-term mutagenicity test: some compounds which are non mutagenic in the Salmonella bio-assay (e.g. diquat) give positive responses, some preparations such as captan become more or less mutagenic, and some, such as triallate, become significantly more toxic to the tester strains. |
0(0,0,0,0) | Details |
| 8240381 | Cornu MC, Moore GA, Nakagawa Y, Moldeus P: uptake by isolated rat hepatocytes. Biochem Pharmacol. 1993 Oct 19;46(8):1333-8. Stimulatory effect of diquat, a redox cycling compound.. |
0(0,0,0,0) | Details |
| 17616690 | Kim EH, Sohn S, Kwon HJ, Kim SU, Kim MJ, Lee SJ, Choi KS: selenite induces -mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells. Cancer Res. 2007 Jul 1;67(13):6314-24. Furthermore, treatment with diquat, a generator, induced autophagic cell death in glioma cells. |
0(0,0,0,0) | Details |
| 15496407 | Ran Q, Liang H, Gu M, Qi W, Walter CA, Roberts LJ 2nd, Herman B, Richardson A, Van Remmen H: Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis. J Biol Chem. 2004 Dec 31;279(53):55137-46. Epub 2004 Oct 20. Cell death induced by t-butylhydroperoxide and diquat was significantly less in murine embryonic fibroblasts from Tg (GPX4) mice compared with wild type mice. |
0(0,0,0,0) | Details |
| 1320687 | Rikans LE, Cai Y: Age-associated enhancement of diquat-induced lipid peroxidation and cytotoxicity in isolated rat hepatocytes. J Pharmacol Exp Ther. 1992 Jul;262(1):271-8. |
0(0,0,0,0) | Details |
| 2825600 | Sandy MS, Moldeus P, Ross D, Smith MT: Cytotoxicity of the redox cycling compound diquat in isolated hepatocytes: involvement of peroxide and transition metals. Arch Biochem Biophys. 1987 Nov 15;259(1):29-37. |
0(0,0,0,0) | Details |