Protein Information

Name dopamine D2 receptor
Synonyms D(2) dopamine receptor; D2DR; D2R; DRD 2; DRD2; Dopamine D2 receptor; Dopamine receptor D2; Dopamine D2 receptors…

Compound Information

Name chloralose
CAS

Reference List

PubMed Abstract RScore(About this table)
9435586 Kirouac GJ, Ciriello J: Cardiovascular depressor responses to stimulation of substantia nigra and ventral tegmental area. Am J Physiol. 1997 Dec;273(6 Pt 2):H2549-57.

Experiments were done in alpha-chloralose-anesthetized, paralyzed, and artificially ventilated rats to investigate the effect of L-glutamate (Glu) stimulation of the substantia nigra (SN) and ventral tegmental area (VTA) on arterial pressure (AP) and heart rate (HR).
Intravenous administration of the dopamine D2-receptor antagonist raclopride significantly attenuated both the MAP (70%) and the HR (54%) responses elicited by stimulation of the transitional region where the SNC merges with the lateral VTA (SNC-VTA region).
1(0,0,0,1) Details
9600656 Vegh A, Papp JG, Semeraro C, Fatehi-Hasanabad Z, Parratt JR: The dopamine receptor agonist Z1046 reduces ischaemia severity in a canine model of coronary artery occlusion. Eur J Pharmacol. 1998 Mar 5;344(2-3):203-13.

Since stimulation of dopamine D2 receptors inhibits noradrenaline release, and because cardiac noradrenaline release has been implicated in the genesis of early ischaemia-induced, life-threatening ventricular arrhythmias, the effect of Z1046 has been examined for its effects on coronary artery occlusion in chloralose urethane anaesthetised mongrel dogs.
31(0,1,1,1) Details