Protein Information

Name G protein coupled receptor
Synonyms ASRT 2; ASRT2; G protein coupled receptor 154; G protein coupled receptor for asthma susceptibility; G protein coupled receptor; G protein coupled receptor PGR14; GPR154; GPRA…

Compound Information

Name cyanamide
CAS cyanamide

Reference List

PubMed Abstract RScore(About this table)
18624922 Cervia D, Martini D, Ristori C, Catalani E, Timperio AM, Bagnoli P, Casini G: Modulation of the neuronal response to ischaemia by somatostatin analogues in wild-type and knock-out mouse retinas. J Neurochem. 2008 Sep;106(5):2224-35. Epub 2008 Jul 9.

Somatostatin acts at five G protein-coupled receptors, sst (1)-sst (5).
In contrast, cell death was increased by blocking sst (2) with cyanamide.
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19605612 Jian K, Barhoumi R, Ko ML, Ko GY: Inhibitory effect of somatostatin-14 on L-type voltage-gated calcium channels in cultured cone photoreceptors requires intracellular calcium. J Neurophysiol. 2009 Sep;102(3):1801-10. Epub 2009 Jul 15.


The action of somatostatin is through G-protein-coupled receptor-mediated second-messenger signaling, which in turn affects other downstream targets including ion channels.
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