Protein Information

Name glutamate receptors (protein family or complex)
Synonyms Glutamate receptor; Glutamate receptors

Compound Information

Name chloralose
CAS

Reference List

PubMed Abstract RScore(About this table)
16914666 Gsell W, Burke M, Wiedermann D, Bonvento G, Silva AC, Dauphin F, Buhrle C, Hoehn M, Schwindt W: Differential effects of NMDA and AMPA glutamate receptors on functional magnetic resonance imaging signals and evoked neuronal activity during forepaw stimulation of the rat. J Neurosci. 2006 Aug 16;26(33):8409-16.

To investigate the role of the two major ionotropic glutamate receptors [NMDA receptors (NMDA-Rs) and AMPA receptors (AMPA-Rs)] for the generation of functional magnetic resonance imaging (fMRI) signals, we used fMRI [measurements of blood oxygenation level-dependent (BOLD), perfusion-weighted imaging (PWI), and cerebral blood volume (CBV)] together with recordings of somatosensory evoked potentials (SEPs) during electrical forepaw stimulation in the alpha-chloralose anesthetized rat.
32(0,1,1,2) Details
11063990 Haxhiu MA, Chavez JC, Pichiule P, Erokwu B, Dreshaj IA: The excitatory amino acid glutamate mediates reflexly increased tracheal blood flow and airway submucosal gland secretion. Brain Res. 2000 Nov 10;883(1):77-86.

In six decerebrated and in eight alpha-chloralose anesthetized, paralyzed and mechanically ventilated beagle dogs, we have studied involvement of glutamate and glutamate receptors in transmission of excitatory inputs from the airway sensory receptors to the nucleus tractus solitarius and from this site to airway-related vagal preganglionic cells that regulate the tracheal circulation and the submucosal gland secretion.
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8594025 Li A, Nattie EE: Prolonged stimulation of respiration by brain stem metabotropic glutamate receptors. J Appl Physiol. 1995 Nov;79(5):1650-6.

Stimulation of metabotropic glutamate receptors (mGluRs) in the retrotrapezoid nucleus (RTN) of chloralose-urethan-anesthetized rats by the mGluR agonist (1S,3R)-aminocyclopentanedicarboxylic acid [(1S,3R)-ACPD; 10 nl, 1 mM] increases integrated phrenic nerve amplitude (PNA) for > 60 min.
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16733059 Cao WH, Morrison SF: Glutamate receptors in the raphe pallidus mediate brown adipose tissue thermogenesis evoked by activation of dorsomedial hypothalamic neurons. Neuropharmacology. 2006 Sep;51(3):426-37. Epub 2006 May 30.

We determined the role of glutamate receptor activation in the rostral raphe pallidus (RPa) in mediating the sympathoexcitatory responses in HR, BAT SNA and RSNA following disinhibition of DMH neurons in urethane/chloralose anesthetized, artificially ventilated rats.
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9479671 Haxhiu MA, Erokwu B, Dreshaj IA: The role of excitatory amino acids in airway reflex responses in anesthetized dogs. J Auton Nerv Syst. 1997 Dec 11;67(3):192-9.

Experiments were performed in chloralose anesthetized, paralyzed and mechanically ventilated beagle dogs (n = 18), under hyperoxic, normocapnic, and normohydric conditions.
Findings indicate that an increase in central cholinergic outflow to the airways by a variety of excitatory afferent inputs is mediated via activation of EAA receptors, mainly AMPA/kainate subtype of glutamate receptors.
1(0,0,0,1) Details
14514030 Morrison SF: Glutamate transmission in the rostral ventrolateral medullary sympathetic premotor pathway. Cell Mol Neurobiol. 2003 Oct;23(4-5):761-72.

Iontophoretic and pressure ejection of glutamate receptor agonists and antagonists was made onto antidromically identified splanchnic and adrenal SPNs before and during electrical stimulation of the RVLM in urethane/chloralose-anesthetized, artificially ventilated rats. 3.
Blockade of glutamate receptors in the IML interrupted the ability of electrical activation of sympathetic premotor neurons in the RVLM to excite SPNs.
1(0,0,0,1) Details
12194013 Bongianni F, Mutolo D, Carfi M, Pantaleo T: Respiratory responses to ionotropic glutamate receptor antagonists in the ventral respiratory group of the rabbit. Pflugers Arch. 2002 Aug;444(5):602-9. Epub 2002 Jun 19.

Selective excitatory amino acid receptor antagonists acting on either N-methyl-D-aspartic acid (NMDA) or non-NMDA receptors were microinjected (30-50 nl) bilaterally into different subregions of the ventral respiratory group (VRG) of alpha-chloralose-urethane anaesthetized, vagotomized, paralysed and artificially ventilated rabbits.
The results suggest that ionotropic glutamate receptors within the iVRG are involved mainly in the control of the intensity of inspiratory activity, with a major role played by NMDA receptors.
1(0,0,0,1) Details
15654849 Mutolo D, Bongianni F, Nardone F, Pantaleo T: Respiratory responses evoked by blockades of ionotropic glutamate receptors within the Botzinger complex and the pre-Botzinger complex of the rabbit. Eur J Neurosci. 2005 Jan;21(1):122-34.

The respiratory role of excitatory amino acid (EAA) receptors within the Botzinger complex (BotC) and the pre-Botzinger complex (pre-BotC) was investigated in alpha-chloralose-urethane anaesthetized, vagotomized, paralysed and artificially ventilated rabbits by using bilateral microinjections (30-50 nL) of EAA receptor antagonists.
1(0,0,0,1) Details
7713805 Nattie EE, Li A: Rat retrotrapezoid nucleus iono- and metabotropic glutamate receptors and the control of breathing. J Appl Physiol. 1995 Jan;78(1):153-63.

The rats were chloralose-urethan anesthetized, paralyzed, vagotomized, and ventilated, and each injection location was verified anatomically.
1(0,0,0,1) Details
15927691 Wang J, Peng YJ, Zhu DN: Amino acids modulate the hypotensive effect of angiotensin-(1-7) at the caudal ventrolateral medulla in rats. Regul Pept. 2005 Jul 15;129(1-3):1-7.

The present experiment was designed to investigate the possible involvement of glutamate and taurine in the depressor response produced by angiotensin (Ang)-(1-7) at the caudal ventrolateral medulla (CVLM) in rats anesthetized with urethane and alpha-chloralose.
Microinjection of Ang-(1-7) into the CVLM elicited a depressor response which was partially blocked by nonselective glutamate receptors antagonist kynurenic acid, whereas selective Ang-(1-7) antagonist Ang779 produced a pressor response which was significantly attenuated by taurine receptors antagonist 6-aminomethyl-3-methyl-4H-1,2,4-benzothiadiazine-1,1-dioxide.
1(0,0,0,1) Details
10338304 Storer RJ, Goadsby PJ: Trigeminovascular nociceptive transmission involves N-methyl-D-aspartate and non-N-methyl-D-aspartate glutamate receptors. Neuroscience. 1999;90(4):1371-6.

Cats were anaesthetized (60 mg/kg alpha-chloralose, i.p., along with halothane for all surgical procedures) and prepared for physiological monitoring.
1(0,0,0,1) Details
7620709 Farkas S, Ono H: Participation of NMDA and non-NMDA excitatory amino acid receptors in the mediation of spinal reflex potentials in rats: an in vivo study. Br J Pharmacol. 1995 Mar;114(6):1193-205.

The drugs investigated in this study, with the exception of ketamine, proved to be useful tools for elucidation of the involvement of EAA receptors in various processes in vivo Keywords: Glutamate receptors; AMPA; kainate; NMDA; NBQX; GYKI 52466; CPP; MK-801; spinal reflex; spinal cord
The effect of various intravenously administered excitatory amino acid (EAA) antagonists on the dorsal root stimulation-evoked, short latency (up to 10 ms) spinal root reflex potentials of chloralose-urethane anaesthetized C1 spinal rats was studied, in order to gain information on the involvement of non-NMDA (AMPA/kainate; AMPA = alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionate) and NMDA (N-methyl-D-aspartate) receptors in their mediation.
1(0,0,0,1) Details
12044639 Peng YJ, Wang N, Gong QL, Li P: Caudal ventrolateral medulla mediates the depressor response elicited by the greater splanchnic nerve afferent stimulation in rats. Neurosci Lett. 2002 Jun 7;325(2):134-8.

In the present study, the possible involvement of the CVLM in mediating the depressor response elicited by the greater splanchnic nerve (GSPL) afferent stimulation was explored in rats anesthetized with urethane and alpha-chloralose.
These results suggest the involvement of CVLM neurons and activation of glutamate receptors in the CVLM in mediating the depressor response induced by the GSPL afferent stimulation in rats.
1(0,0,0,1) Details
8828691 Motekaitis AM, Solomon IC, Kaufman MP: Blockade of glutamate receptors in CVLM and NTS attenuates airway dilation evoked from parabrachial region. J Appl Physiol. 1996 Jul;81(1):400-7.

Using chloralose-anesthetized cats, we assessed the airway dilation evoked from the parabrachial region before and during bilateral blockade of the NTS or the CVLM.
1(0,0,0,1) Details
9815076 Liu Z, Chen CY, Bonham AC: Metabotropic glutamate receptors depress vagal and aortic baroreceptor signal transmission in the NTS. Am J Physiol. 1998 Nov;275(5 Pt 2):H1682-94.

In alpha-chloralose-anesthetized rabbits, we determined the number of extracellular action potentials synaptically evoked by low (1 Hz)- or high-frequency vagal (3-20 Hz) or aortic depressor nerve (ADN) (6-80 Hz) stimulation and postsynaptically evoked by the ionotropic glutamate receptor agonist alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA).
The results suggest that metabotropic glutamate receptors, presumably at presynaptic sites, contribute to frequency-dependent depression of vagal and aortic baroreceptor signal transmission in NTS.
1(0,0,0,1) Details
15020305 Chianca DA Jr, Lin LH, Dragon DN, Talman WT: NMDA receptors in nucleus tractus solitarii are linked to soluble guanylate cyclase. Am J Physiol Heart Circ Physiol. 2004 Apr;286(4):H1521-7.


In adult male Sprague-Dawley rats anesthetized with chloralose, the ionotropic receptor agonists N-methyl-d-aspartate (NMDA) and dl-alpha-amino-3-hydroxy-5-methylisoxazole-propionic acid (AMPA) and the metabotropic receptor agonist trans-dl-amino-1,3-cyclopentane-dicarboxylic acid (ACPD) were microinjected into the NTS before and after microinjection of sGC inhibitors at the same site.
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20065145 Bardgett ME, McCarthy JJ, Stocker SD: Glutamatergic receptor activation in the rostral ventrolateral medulla mediates the sympathoexcitatory response to hyperinsulinemia. Hypertension. 2010 Feb;55(2):284-90. Epub 2010 Jan 11.


Hyperinsulinemic-euglycemic clamps were performed in alpha-chloralose anesthetized, male Sprague-Dawley rats by infusion of insulin (3.75 mU/kg per minute, IV) and 50% dextrose solution for 120 minutes.
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15525805 Solomon IC: Glutamate neurotransmission is not required for, but may modulate, hypoxic sensitivity of pre-Botzinger complex in vivo. J Neurophysiol. 2005 Mar;93(3):1278-84. Epub 2004 Nov 3.


To test this possibility, the effects of focal pre-BotC hypoxia [induced by sodium cyanide (NaCN)] were examined before and after blockade of ionotropic EAA receptors [using kynurenic acid (KYN)] in this region in chloralose-anesthetized, vagotomized, mechanically ventilated cats.
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