| Name | serotonin 1A receptor |
|---|---|
| Synonyms | 5 HT 1A; serotonin receptor; 5 HT1A; 5 hydroxytryptamine (serotonin) receptor 1A; 5 hydroxytryptamine 1A receptor; 5HT1A; ADRB2RL1; ADRBRL 1… |
| Name | chloralose |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1673069 | Dreteler GH, Wouters W, Saxena PR, Ramage AG: Pressor effects following microinjection of 5-HT1A receptor agonists into the raphe obscurus of the anaesthetized rat. Br J Pharmacol. 1991 Feb;102(2):317-22. The effects of electrical stimulation and microinjections (90 nl) of the 5-HT1A receptor agonists, flesinoxan and 8--2-(di-n-propylamino) tetralin (8-OH-DPAT), and into the raphe obscurus on blood pressure, heart rate and phrenic nerve activity (central inspiratory drive) were investigated in rats anaesthetized with alpha-chloralose. 2. |
34(0,1,1,4) | Details |
| 8301586 | Escandon NA, Zimmermann DC, McCall RB: Characterization of the serotonin1A receptor antagonist activity of WAY-100135 and spiperone. J Pharmacol Exp Ther. 1994 Jan;268(1):441-7. The effects of the putative (5-HT) 1A receptor antagonists WAY-100135 (WAY) and spiperone on the neuronal activity recorded from medullary and dorsal raphe neurons and the inferior cardiac sympathetic nerve were investigated in chloralose anesthetized cats. |
34(0,1,1,4) | Details |
| 16931649 | Nakamura K, Morrison SF: Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue. Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R127-36. Epub 2006 Aug 24. Here, we examined the involvement of several autonomic brain regions in sympathetic thermogenic responses in brown adipose tissue (BAT) to skin cooling in urethane-chloralose-anesthetized rats by monitoring thermogenic [BAT sympathetic nerve activity (SNA) and BAT temperature], metabolic (expired CO (2)), and cardiovascular (arterial pressure and heart rate) parameters. |
0(0,0,0,0) | Details |
| 15197536 | Lambert GA, Donaldson C, Hoskin KL, Boers PM, Zagami AS: Dilatation induced by in the middle meningeal artery of the anaesthetised cat. Naunyn Schmiedebergs Arch Pharmacol. 2004 Jun;369(6):591-601. Epub 2004 May 7. In chloralose-anaesthetised cats, we studied the effects of intravenous and intra-carotid injections of on the middle meningeal artery and the way these were modified by antagonists. |
0(0,0,0,0) | Details |
| 17204596 | Dolber PC, Gu B, Zhang X, Fraser MO, Thor KB, Reiter JP: Activation of the external urethral sphincter central pattern generator by a 5-HT (1A) receptor agonist in rats with chronic spinal cord injury. Am J Physiol Regul Integr Comp Physiol. 2007 Apr;292(4):R1699-706. Epub 2007 Jan 4. We recently demonstrated that treatment with the 5-HT (1A/7) receptor agonist [(R)-(+)-8--2-di-n-propylamino] tetralin (8-OH-DPAT) increases bladder capacity in chloralose-anesthetized female cats with chronic spinal cord injury. |
33(0,1,1,3) | Details |
| 16488413 | Tai C, Miscik CL, Ungerer TD, Roppolo JR, de Groat WC: Suppression of bladder reflex activity in chronic spinal cord injured cats by activation of 5-HT1A receptors. Exp Neurol. 2006 Jun;199(2):427-37. Epub 2006 Feb 20. The effects of 8-OH-DPAT (5-HT1A receptor agonist) and WAY100635 (5-HT1A receptor antagonist) on reflex bladder activity were investigated in alpha-chloralose anesthetized or conscious chronic spinal cord injured cats. |
33(0,1,1,3) | Details |
| 1686389 | Tsuji R, Ohno Y, Hirose A, Shimizu H, Tanaka H, Nakamura M: Effects of tandospirone, a 5-HT1A receptor-related anxiolytic, on the pressor response elicited by stimulation of the posterior hypothalamus in cats. Arch Int Pharmacodyn Ther. 1991 May-Jun;311:131-43. The effects of tandospirone, a novel 5-HT1A receptor-related anxiolytic, on pressor responses elicited by activation of the posterior hypothalamus were examined in alpha-chloralose-anesthetized cats and compared with those of diazepam and tofisopam. |
33(0,1,1,3) | Details |
| 11691870 | Wang Y, Ramage AG: The role of central 5-HT (1A) receptors in the control of B-fibre cardiac and bronchoconstrictor vagal preganglionic neurones in anaesthetized cats. J Physiol. 2001 Nov 1;536(Pt 3):753-67. These experiments were carried out on alpha-chloralose-anaesthetized, artificially ventilated and (1 mg kg (-1))-pretreated cats. 2. |
5(0,0,0,5) | Details |
| 18082230 | Madden CJ, Morrison SF: Brown adipose tissue sympathetic nerve activity is potentiated by activation of (5-HT) 1A/5-HT7 receptors in the rat spinal cord. Neuropharmacology. 2008 Mar;54(3):487-96. Epub 2007 Nov 5. In urethane-chloralose anesthetized, neuromuscularly blocked, ventilated rats, microinjection of (12 pmol) into the right fourth thoracic segment (T4) spinal intermediolateral nucleus (IML) immediately increased ipsilateral brown adipose tissue (BAT) sympathetic nerve activity (SNA; peak +492% of control), expired CO2 (+0.1%) heart rate (+48 beats min (-1)) and arterial pressure (+8 mmHg). |
4(0,0,0,4) | Details |
| 8032949 | Kishimoto T, Yamanaka T, Amano T, Todo N, Sasa M: 5-HT1A receptor-mediated inhibition of lateral vestibular nucleus neurons projecting to the abducens nucleus. Brain Res. 1994 Apr 25;644(1):47-51. Electrophysiological studies were performed using cats anesthetized with alpha-chloralose, to elucidate the receptor subtypes involved in the -induced inhibition of the lateral vestibular nucleus (LVN) neurons projecting to or through the abducens nucleus. |
4(0,0,0,4) | Details |
| 7537469 | Nobrega AC, Meintjes AF, Ally A, Wilson LB: Modulation of reflex pressor response to contraction and effect on substance P release by spinal 5-HT1A receptors. Am J Physiol. 1995 Apr;268(4 Pt 2):H1577-85. Static contractions of the triceps surae muscle of chloralose-anesthetized cats were induced by stimulating the cut L7 and S1 ventral roots. |
4(0,0,0,4) | Details |
| 1674536 | Mandal AK, Kellar KJ, Gillis RA: The role of serotonin-1A receptor activation and alpha-1 adrenoceptor blockade in the hypotensive effect of 5-methyl-urapidil. J Pharmacol Exp Ther. 1991 May;257(2):861-9. In terms of the first purpose, 5-methyl-urapidil applied bilaterally to the intermediate area of the ventral surface of the medulla (1.2 micrograms/side) of chloralose-anesthetized cats produced a decrease in mean arterial pressure of -39 +/- 4 mm Hg (N = 8). |
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| 15152026 | Gu B, Olejar KJ, Reiter JP, Thor KB, Dolber PC: Inhibition of bladder activity by 5-hydroxytryptamine1 serotonin receptor agonists in cats with chronic spinal cord injury. J Pharmacol Exp Ther. 2004 Sep;310(3):1266-72. Epub 2004 May 19. We also investigated GR-46611 (3-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl) acrylamide) , which has agonist activity predominantly at 5-HT1B and 5-HT1D receptors but also at the 5-HT1A receptor. Chloralose-anesthetized cats were catheterized through the bladder dome for saline-filling cystometry. |
3(0,0,0,3) | Details |
| 20071609 | Madden CJ, Morrison SF: Endogenous activation of spinal receptors contributes to the thermoregulatory activation of brown adipose tissue. Am J Physiol Regul Integr Comp Physiol. 2010 Mar;298(3):R776-83. Epub 2010 Jan 13. In urethane/chloralose-anesthetized rats, whole body cooling decreased skin (-5.7 +/- 2.3 degrees C) and core (-1.3 +/- 0.2 degrees C) temperatures and resulted in an increase in BAT sympathetic nerve activity (SNA; +1,026 +/- 344% of baseline activity). Microinjections of the 5-HT (1A) receptor antagonist, WAY-100635 (1.2 nmol/site), or the 5-HT (7) receptor antagonist, SB-269970 (1.2 nmol/site), into the T2-T5 IML also attenuated the cold-evoked increase in BAT SNA (remaining activity at peak inhibition: 47 +/- 8% and 39 +/- 12% of the initial cold-evoked response, respectively). |
2(0,0,0,2) | Details |
| 1467825 | Anderson IK, Martin GR, Ramage AG: Central administration of activates 5-HT1A receptors to cause sympathoexcitation and 5-HT2/5-HT1C receptors to release in anaesthetized rats. Br J Pharmacol. 1992 Dec;107(4):1020-8. The effects of intracerebroventricular injections to the right lateral ventricle (i.c.v.) of 40 and 120 nmol kg-1), N,N-di-n-propyl-5-carboxamidotryptamine (DP-5-CT; 3 nmol kg-1), 5-carboxamidotryptamine (5-CT; 3 nmol kg-1), 8--2-(di-N-propylamino) tetralin (8-OH-DPAT; 3, 40 and 120 nmol kg-1) and 1-(2,5-di-methoxy-4-iodophenyl)-2-aminopropane (DOI; 40 and 120 nmol kg-1) on renal sympathetic nerve activity, blood pressure, heart rate and phrenic nerve activity were investigated in normotensive rats anaesthetized with alpha-chloralose. 2. caused a long lasting pressor response which was associated with an initial bradycardia and renal sympathoinhibition followed by a tachycardia and renal sympathoexcitation. |
2(0,0,0,2) | Details |
| 8169828 | Chamienia AL, Johns EJ: Renal functional responses to the 5-HT1A receptor agonist flesinoxan: effects of controlled renal perfusion pressure. J Pharmacol Exp Ther. 1994 Apr;269(1):215-20. In groups of chloralose/urethane-anesthetized Wistar rats, reduction in left kidney RPP significantly decreased the glomerular filtration rate (GFR), with much larger decreases in urine flow (UV) and absolute (UNaV) and fractional (FENa) excretions, but raised systemic pressure as well as right kidney GFR and water and excretion. |
2(0,0,0,2) | Details |
| 8097247 | Krowicki ZK, Hornby PJ: microinjected into the nucleus raphe obscurus increases intragastric pressure in the rat via a vagally mediated pathway. J Pharmacol Exp Ther. 1993 Apr;265(1):468-76. The purpose of the present study was to investigate the effect of microinjection of and selected receptor subtype agonists and antagonists into the caudal nucleus raphe obscurus on gastrointestinal motor activity in urethane-chloralose anesthetized rats. Microinjection of a 5-HT1A receptor agonist, 8--N,N-dipropyl-2-amino-tetralin hydrobromide (0.06-12.0 nmol), a 5-HT1C/2 receptor agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl (4.5 and 18.0 nmol), as well as a 5-HT3 receptor agonist, 1-(m-chlorophenyl)-biguanide hydrochloride (0.6-18.0 nmol), also resulted in increases in intragastric pressure. |
2(0,0,0,2) | Details |
| 8032644 | Chamienia AL, Johns EJ: The renal functional responses to 5-HT1A receptor agonist, flesinoxan, in anaesthetized, normotensive rat. Br J Pharmacol. 1994 May;112(1):214-8. In chloralose-urethane anaesthetized Wistar rats, i.v. administration of bolus doses of flesinoxan, at 30, 100, 300 and 1000 micrograms kg-1, caused significant, dose-dependent decreases in mean arterial pressure, of 33 +/- 2 mmHg (P < 0.001) and heart rate of 57 +/- 9 beats min-1 (P < 0.001) at the highest dose used. |
2(0,0,0,2) | Details |
| 20164207 | Karicheti V, Langdale CL, Ukai M, Thor KB: Characterization of a "Spinal - Urine Storage Reflex - Inhibitory Center" (SUSRIC) and Its Regulation by 5-HT1A Receptors in Female Cats. Am J Physiol Regul Integr Comp Physiol. 2010 Feb 17. Electrical stimulation of PEL nerves produced evoked potentials recorded by URS EMG electrodes (10 msec latency) or HgN nerve electrodes (60 msec latency) in chloralose-anesthetized cats. |
2(0,0,0,2) | Details |
| 1855130 | Ramage AG: The mechanism of the sympathoinhibitory action of urapidil: role of 5-HT1A receptors. Br J Pharmacol. 1991 Apr;102(4):998-1002. Cats were anaesthetized with alpha-chloralose and simultaneous recordings were made of whole cardiac, splanchnic and renal nerve activities, blood pressure, heart rate and femoral arterial flow (from which conductance was derived). |
2(0,0,0,2) | Details |
| 8004405 | Shepheard SL, Jordan D, Ramage AG: Comparison of the effects of IVth ventricular administration of some analogues with those of 8-OH-DPAT on autonomic outflow in the anaesthetized cat. Br J Pharmacol. 1994 Feb;111(2):616-24. It is concluded that the present data support the view that 5-HT1A receptors at the level of the brainstem are involved in the central sympathoinhibitory effects caused by intravenous administration of 5-HT1A agonists. 1 The present study compares the effects on representative autonomic outflows of IVth ventricular application of analogues which act at 5-HT1 receptors with 8--2-(di-n-propylamino) tetralin (8-OH-DPAT). 2 Cumulative doses of 8-OH-DPAT, N,N-di-n-propyl-5-carboxamidotryptamine (DP-5-CT) and 5-carboxamidotryptamine (5-CT, 2.5-40 nmol kg-1), (10-160 nmol kg-1), indorenate (100-800 nmol kg-1), 20-640 nmol kg-1) both alone and in the presence of cinanserin (0.1 mg kg-1) were given into the IVth ventricle of cats which were anaesthetized with a mixture of alpha-chloralose and pentobarbitone neuromuscularly blocked and artificially ventilated. |
2(0,0,0,2) | Details |
| 8646420 | Bootle DJ, Adcock JJ, Ramage AG: Involvement of central 5-HT1A receptors in the reflex activation of pulmonary vagal motoneurones by inhaled in anaesthetized cats. Br J Pharmacol. 1996 Feb;117(4):724-8. It is concluded that the reflex excitation of pulmonary vagal motoneurones by inhaled in alpha-chloralose anaesthetized cats involves the activation of central 5-HT1A receptors. |
115(1,2,2,5) | Details |
| 7965796 | McCall RB, Escandon NA, Harris LT, Clement ME: Tolerance development to the vagal-mediated bradycardia produced by 5-HT1A receptor agonists. J Pharmacol Exp Ther. 1994 Nov;271(2):776-81. The purpose of this study was to characterize the bradycardic effects of (5-HT) 1A receptor agonists in the chloralose-anesthetized spinal cat and to determine if tolerance develops to the bradycardia produced by these drugs. 5-HT1A receptor agonists studied included 8--2-(di-n-propylamino) tetralin (8-OH-DPAT), gepirone, flesinoxan and U-93385E (cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro-3-propyl-1H-benz [e] -9 - carboxamide). |
83(1,1,1,3) | Details |
| 14742306 | Morrison SF: Activation of 5-HT1A receptors in raphe pallidus inhibits leptin-evoked increases in brown adipose tissue thermogenesis. Am J Physiol Regul Integr Comp Physiol. 2004 May;286(5):R832-7. Epub 2004 Jan 23. To elucidate the central neural pathways contributing to the thermogenic component of the autonomic response to intravenous administration of leptin, experiments were conducted in urethane-chloralose-anesthetized, ventilated rats to address 1) the role of neurons in the rostral ventromedial medulla, including raphe pallidus (RPa), in the leptin-evoked stimulation of brown adipose tissue (BAT) sympathetic nerve activity (SNA); and 2) the potential thermolytic effect of (1A) (5-HT (1A)) receptors on RPa neurons that influence BAT thermogenesis. |
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| 9680249 | Bootle DJ, Adcock JJ, Ramage AG: The role of central receptors in the bronchoconstriction evoked by inhaled in anaesthetised guinea-pigs. Neuropharmacology. 1998;37(2):243-50. The effects of intracisternal (i.c) injections of the 5-HT1A receptor agonists, and 8-OH-DPAT, and the antagonists WAY-100635; and (-)-pindolol, the 5-HT1B/1D receptor agonist and antagonist GR127935, the 5-HT2 receptor agonist DOI and the antagonist cinanserin, the 5-HT3 receptor antagonist granisetron, the alpha-adrenoceptor agonist clonidine and the antagonist idazoxan, the D2 receptor antagonists (-)-sulpiride and the uptake inhibitor fluoxetine on -evoked increase in tracheal inflation pressure (bronchoconstriction) were investigated in alpha-chloralose anaesthetised, neuromuscularly blocked, artificially ventilated guinea-pigs. |
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| 17509363 | Gu B, Thor KB, Reiter JP, Dolber PC: Effect of 5-hydroxytryptamine1 serotonin receptor agonists on noxiously stimulated micturition in cats with chronic spinal cord injury. J Urol. 2007 Jun;177(6):2381-5. Because 5-hydroxytryptamine (1A) receptor agonists increased bladder capacity under saline or acid infused conditions, they are promising candidates for decreasing bladder hyperactivity and increasing bladder capacity in patients with chronic spinal cord injury. MATERIALS AND METHODS: Chloralose anesthetized, spinal cord injured cats were catheterized through the bladder dome for filling cystometry during 0.5% infusion. |
1(0,0,0,1) | Details |
| 8864520 | Chamienia AL, Johns EJ: The cardiovascular and renal functional responses to the 5-HT1A receptor agonist flesinoxan in two rat models of hypertension. Br J Pharmacol. 1996 Aug;118(8):1891-8. This study investigated the importance of renal sympathetic nerves in regulating and water excretion from the kidneys of stroke prone spontaneously hypertensive and 2K1C Goldblatt hypertensive rats anaesthetized with chloralose/urethane (17.5/300 mg initially and supplemented at regular intervals), and prepared for measurement of renal function. 2. |
1(0,0,0,1) | Details |