Name | CPPI |
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Synonyms | CPP 1; CPP1; CPPI; CTSC; Cathepsin C; Cathepsin C isoform a preproprotein variant; Cathepsin J; DPP 1… |
Name | cyanamide |
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CAS | cyanamide |
PubMed | Abstract | RScore(About this table) | |
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12926953 | Jurgens B, Irran E, Senker J, Kroll P, Muller H, Schnick W: Melem (2,5,8-triamino-tri-s-triazine), an important intermediate during condensation of melamine rings to graphitic carbon nitride: synthesis, structure determination by X-ray powder diffractometry, solid-state NMR, and theoretical studies. J Am Chem Soc. 2003 Aug 27;125(34):10288-300. Single-phase melem (2,5,8-triamino-tri-s-triazine) C (6) N (7)(NH (2))(3) was obtained as a crystalline powder by thermal treatment of different less condensed C-N-H compounds (e.g., melamine C (3) N (3)(NH (2))(3), dicyandiamide H (4) C (2) N (4), ammonium dicyanamide NH (4)[N (CN)(2)], or cyanamide H (2) CN (2), respectively) at temperatures up to 450 degrees C in sealed glass ampules. The presence of the triamino form instead of other possible tautomers was confirmed by a CPPI (cross-polarization combined with polarization inversion) experiment. |
1(0,0,0,1) | Details |
20337582 | Guay D, Beaulieu C, Percival MD: Therapeutic Utility and Medicinal Chemistry of Cathepsin C Inhibitors. . Curr Top Med Chem. 2010 Mar 26. Nearly all potent and selective Cat C inhibitors described are based on the preferred dipeptide substrates bearing either irreversible (e.g. diazomethylketone, acyloxymethyl ketone, o-acyl hydroxamic acid and vinyl sulfone) or reversible (e.g. semicarbazide, nitrile and cyanamide) electrophilic warheads. |
3(0,0,0,3) | Details |