Protein Information

Name a collagen
Synonyms A collagen; Alpha 1 type XIII collagen isoform 1; Alpha 1 type XIII collagen; Alpha 2 type IV collagen; B collagen; C collagen; COL13A1; COL4A2…

Compound Information

Name cyanamide
CAS cyanamide

Reference List

PubMed Abstract RScore(About this table)
1596476 Cote MF, Sirois E, Doillon CJ: In vitro contraction rate of collagen in sponge-shape matrices. J Biomater Sci Polym Ed. 1992;3(4):301-13.

Connective tissue substitute can be made of collagen sponge-shaped matrice which is reconstituted by freeze-drying a collagen dispersion.
In the present study, collagen dispersions made of collagen fibrils with a D-staggered pattern were submitted to the following treatments: (1) cyanamide or glutaraldehyde was introduced during the dispersion step followed by the manufacture of sponges; (2) uncrosslinked sponges were exposed to formaldehyde vapor; or (3) uncrosslinked and crosslinked sponges were severely dehydrated.
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2633337 Wasserman AJ, Kato YP, Christiansen D, Dunn MG, Silver FH: Achilles tendon replacement by a collagen fiber prosthesis: morphological evaluation of neotendon formation. Scanning Microsc. 1989 Dec;3(4):1183-97; discussion 1197-200.

Reconstituted type I collagen was processed into fibers which were subsequently severely dehydrated and cyanamide cross-linked.
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8113935 Dunn MG, Maxian SH, Zawadsky JP: Intraosseous incorporation of composite collagen prostheses designed for ligament reconstruction. J Orthop Res. 1994 Jan;12(1):128-37.

Prostheses were fabricated by the alignment of 200 reconstituted type-I collagen fibers (60 microns in diameter) and the embedding of the fibers within a collagen matrix.
Dehydrothermal-cyanamide crosslinked collagen fibers were completely degraded by 8 weeks.
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