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Neudecker T, Henschler D: Allyl isothiocyanate is mutagenic in Salmonella typhimurium. Mutat Res. 1985 Apr-May;156(1-2):33-7.
SKF525, inhibitor of microsomal oxygenase, reduces the mutagenic potential which on the other hand is increased in the presence of 1,1,1-trichloropropene-2-oxide, inhibitor of epoxide hydrolase.
Another metabolic pathway, namely hydrolysis to allyl alcohol and oxidation to acrolein, a known mutagen, also seems possible as cyanamide, inhibitor of aldehyde dehydrogenase, can slightly increase the mutagenic potential. |
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