Protein Information

Name monoamine oxidase
Synonyms Adrenalin oxidase; Amine oxidase; Amine oxidase [flavin containing] B; MAO B; MAOB; Monoamine oxidase; Monoamine oxidase B; Monoamine oxidase type B…

Compound Information

Name cyanamide
CAS cyanamide

Reference List

PubMed Abstract RScore(About this table)
7159468 Hellstrom E, Tottmar O: Effects of aldehyde dehydrogenase inhibitors on enzymes involved in the metabolism of biogenic aldehydes in rat liver and brain. Biochem Pharmacol. 1982 Dec 1;31(23):3899-905.

The effects of the aldehyde dehydrogenase inhibitors disulfiram, coprine and cyanamide on enzymes involved in the metabolism of biogenic aldehydes in rat liver and brain were studied.
None of the drugs caused any changes in the activities of aldehyde reductase and monoamine oxidase in brains in vivo.
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12237745 Mega BT, Sheppard KW, Williams HL, McMillen BA: On the role of monoamine oxidase-A for the maintenance of the volitional consumption of ethanol in two different rat models. Naunyn Schmiedebergs Arch Pharmacol. 2002 Oct;366(4):319-26. Epub 2002 Aug 20.

Specifically, hydrogen peroxide may be used as a co-substrate for the metabolism of ethanol to acetaldehyde by catalase and the action of monoamine oxidase in the monoaminergic neurons would supply the hydrogen peroxide.
In the cyanamide-induced drinking rat, 50 mg/kg BW A616U reduced consumption of ethanol by 37%.
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6884350 Muller A, Sies H: Ethane release during metabolism of aldehydes and monoamines in perfused rat liver. Eur J Biochem. 1983 Aug 15;134(3):599-602.

Compounds which metabolically generate aldehydes such as monoamines (benzylamine, phenylethylamine) as substrates for monoamine oxidase or ethanol as substrate for alcohol dehydrogenase [A.
Results obtained with inhibitors of hepatic aldehyde metabolism (pargyline or cyanamide) or of monamine oxidase (pargyline or tranylcypromine) suggest that metabolism of the aldehydes is required for ethane production.
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12269395 Imamura Y, Wu X, Noda A, Noda H: Side-chain metabolism of propranolol: involvement of monoamine oxidase and mitochondrial aldehyde dehydrogenase in the metabolism of N-desisopropylpropranolol to naphthoxylactic acid in rat liver. Life Sci. 2002 Apr 19;70(22):2687-97.

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1987314 Zimatkin SM: Histochemical study of aldehyde dehydrogenase in the rat CNS. J Neurochem. 1991 Jan;56(1):1-11.


A positive correlation was demonstrated between the distribution of ALDH activity among rat CNS microregions (our own data) and the density of dopaminergic terminals, dopamine content, and monoamine oxidase activity (literature data) among the same microregions.
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6861004 Loomis CW, Brien JF: Specificity of hepatic aldehyde dehydrogenase inhibition by calcium carbimide (calcium cyanamide) in the rat. Can J Physiol Pharmacol. 1983 Apr;61(4):431-5.

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