| 17449253 |
Ronn R, Gossas T, Sabnis YA, Daoud H, Kerblom E, Danielson UH, Sandstrom A: Evaluation of a diverse set of potential P1 carboxylic acid bioisosteres in hepatitis C virus NS3 protease inhibitors. Bioorg Med Chem. 2007 Jun 15;15(12):4057-68. Epub 2007 Apr 4.
Additionally, results from a pH-study suggest that the P (1) C-terminal of the inhibitors comprising a carboxylic acid, an acyl sulfonamide or an acyl cyanamide group binds in a similar mode in the active site of the NS3 protease. |
85(1,1,1,5) |
Details |