Protein Information

Name aspartate aminotransferase
Synonyms Aspartate Aminotransferase 1; GIG18; GOT 1; GOT1; Aspartate aminotransferase; Glutamate oxaloacetate transaminase 1; Transaminase A; Aspartate aminotransferases…

Compound Information

Name cyanamide
CAS cyanamide

Reference List

PubMed Abstract RScore(About this table)
3663401 Solomon LR: Evidence for the generation of transaminase inhibitor (s) during ethanol metabolism by rat liver homogenates: a potential mechanism for alcohol toxicity. Biochem Med Metab Biol. 1987 Aug;38(1):9-18.

When homogenates were incubated at 37 degrees with 50 mM ethanol for 1 hr, alanine aminotransferase decreased by 20%, while aspartate aminotransferase was unchanged.
Cyanamide, an aldehyde dehydrogenase inhibitor, had little effect on ethanol-mediated transaminase inhibition.
3(0,0,0,3) Details
10803789 Tamai H, Yokoyama A, Okuyama K, Takahashi H, Maruyama K, Suzuki Y, Ishii H: Comparison of cyanamide and disulfiram in effects on liver function. . Alcohol Clin Exp Res. 2000 Apr;24(4 Suppl):97S-99S.

Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels obtained at 0, 4, 8, and 12 weeks of administration of each aversive drug were compared between the two alcoholic groups.
1(0,0,0,1) Details