Protein Information

Name corticotropin releasing factor
Synonyms CRF; CRH; Corticoliberin; Corticoliberin precursor; Corticotropin releasing factor; Corticotropin releasing hormone; Corticoliberins; Corticoliberin precursors…

Compound Information

Name chloralose
CAS

Reference List

PubMed Abstract RScore(About this table)
16580142 Cerri M, Morrison SF: Corticotropin releasing factor increases in brown adipose tissue thermogenesis and heart rate through dorsomedial hypothalamus and medullary raphe pallidus. Neuroscience. 2006 Jun 30;140(2):711-21. Epub 2006 Mar 31.

To identify potential central pathways through which hypothalamic corticotropin releasing factor influences brown adipose tissue thermogenesis, corticotropin releasing factor was microinjected into the lateral ventricle (i.c.v.) or into hypothalamic sites while recording sympathetic outflow to brown adipose tissue, brown adipose tissue temperature, expired CO2, heart rate and arterial pressure in urethane/chloralose-anesthetized, artificially-ventilated rats.
11(0,0,1,6) Details
18423439 Okada S, Yamaguchi-Shima N, Shimizu T, Arai J, Lianyi L, Wakiguchi H, Yokotani K: Role of brain nicotinic acetylcholine receptor in centrally administered corticotropin-releasing factor-induced elevation of plasma corticosterone in rats. Eur J Pharmacol. 2008 Jun 10;587(1-3):322-9. Epub 2008 Mar 14.

The present study was undertaken to clarify the central mechanisms involved in the intracerebroventricularly administered corticotropin-releasing factor-induced elevation of plasma corticosterone in urethane- and alpha-chloralose-anesthetized rats using microdialysis and immunohistochemical techniques.
10(0,0,1,5) Details
9479672 Katafuchi T, Ichijo T, Hori T: Sequential relationship between actions of CRF and PGE2 in the brain on splenic sympathetic nerve activity in rats. J Auton Nerv Syst. 1997 Dec 11;67(3):200-6.

An infusion of corticotropin-releasing factor (CRF, 0.1-5.0 micrograms/10 microliters/rat) into the third cerebral ventricle (i.c.v.) for 10 min increased the splenic sympathetic nerve activity in a dose-dependent manner in urethane + alpha-chloralose anesthetized rats.
6(0,0,1,1) Details
7922597 Ichijo T, Katafuchi T, Hori T: Central interleukin-1 beta enhances splenic sympathetic nerve activity in rats. Brain Res Bull. 1994;34(6):547-53.

An intrathird cerebroventricular (I3V) infusion of recombinant human IL-1 beta (rhIL-1 beta) (1-5 ng/rat) elicited a dose-dependent increase in the electrical activity of the splenic sympathetic nerve in urethane and alpha-chloralose anesthetized rats.
Furthermore, an antagonist of corticotropin-releasing factor (CRF), alpha-helical CRF9-41 (2 micrograms/rat), completely abolished the rhIL-1 beta-induced increase in the splenic nerve activity, although an I3V infusion of CRF (1 microgram/rat) excited it.
1(0,0,0,1) Details
7914072 Carlson DE, Nabavian AM, Gann DS: Corticotropin-releasing hormone but not glutamate elicits hormonal responses from the parabrachial region in cats. Am J Physiol. 1994 Jul;267(1 Pt 2):R337-48.

Corticotropin-releasing hormone (CRH)-containing processes were found by immunohistochemistry in the dorsal and lateral parabrachial nucleus extending medially over the dorsal aspect of the brachium and then along the lateral and medial aspects of the mesencephalic trigeminal tract.
To determine if CRH acts in these areas to modulate plasma adrenocorticotropic hormone (ACTH) and arginine vasopressin (AVP), acutely prepared, chloralose-anesthetized cats were tested with microinjections (100 nl/min, 2 min).
1(0,0,0,1) Details