| 12876071 |
Nakahara T, Hashimoto K, Hirano M, Koll M, Martin CR, Preedy VR: Acute and chronic effects of alcohol exposure on skeletal muscle c-myc, p53, and Bcl-2 mRNA expression. Am J Physiol Endocrinol Metab. 2003 Dec;285(6):E1273-81. Epub 2003 Jul 22.
The results showed that 1) in male rats fed ethanol chronically, there were no increases in c-myc mRNA; 2) increases, however, occurred in c-myc mRNA in muscle from female rats fed ethanol chronically; 3) raising endogenous acetaldehyde with cyanamide increased c-myc mRNA in acute studies; 4) starvation per se increased c-myc mRNA levels and at 1 day potentiated the acute effects of ethanol, indicative of a sensitization response; 5) the only effect seen with p53 mRNA levels was a decrease in muscle of rats starved for 1 day compared with fed rats, and there was no statistically significant effect on Bcl-2 mRNA in any of the experimental conditions. |
3(0,0,0,3) |
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| 12003908 |
Jankala H, Eriksson CJ, Eklund KK, Harkonen M, Maki T: Combined calcium carbimide and ethanol treatment induces high blood acetaldehyde levels, myocardial apoptosis and altered expression of apoptosis-regulating genes in rat. Alcohol Alcohol. 2002 May-Jun;37(3):222-8.
In the 2-day treatment group, p21 gene expression was increased by 25% and bax/bcl-2 mRNA ratio by 57% in E + CC, compared to the control, group. |
2(0,0,0,2) |
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