| 18317950 |
Vary TC, Lang CH: Differential phosphorylation of translation initiation regulators 4EBP1, S6k1, and Erk 1/2 following inhibition of alcohol metabolism in mouse heart. Cardiovasc Toxicol. 2008 Mar;8(1):23-32. Epub 2008 Mar 4.
Phosphorylation of 4E-BP1, S6k1 (Thr (389)), and Erk 1/2 was reduced 2 h following IP injection of alcohol.
Pretreatment with cyanamide, an inhibitor of aldehyde dehydrogenase, did not attenuate the ethanol-induced decrease in phosphorylation S6k1 (Thr (389)), but partially prevented the ethanol-induced lowering of 4EBP1 phosphorylation. |
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