| Name | ALDH 2 |
|---|---|
| Synonyms | ALDH class 2; ALDH 2; ALDH E2; ALDH2; ALDHI; ALDM; Aldehyde dehydrogenase 2; DHAM… |
| Name | cyanamide |
|---|---|
| CAS | cyanamide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17585900 | Chen YR, Nie SD, Shan W, Jiang DJ, Shi RZ, Zhou Z, Guo R, Zhang Z, Li YJ: Decrease in endogenous CGRP release in nitroglycerin tolerance: role of ALDH-2. Eur J Pharmacol. 2007 Sep 24;571(1):44-50. Epub 2007 Jun 5. |
8(0,0,0,8) | Details |
| 18272654 | Huellner MW, Schrepfer S, Weyand M, Weiner H, Wimplinger I, Eschenhagen T, Rau T: Inhibition of aldehyde dehydrogenase type 2 attenuates vasodilatory action of nitroglycerin in human veins. FASEB J. 2008 Jul;22(7):2561-8. Epub 2008 Feb 13. Recent studies suggest that the mitochondrial aldehyde dehydrogenase (ALDH) 2 is involved in vascular bioactivation of nitroglycerin (GTN). In vitro contraction experiments were performed in the presence or absence of the ALDH inhibitors chloral hydrate, cyanamide, and ethoxycyclopropanol. |
5(0,0,0,5) | Details |
| 18787169 | Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, Mochly-Rosen D: Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science. 2008 Sep 12;321(5895):1493-5. |
4(0,0,0,4) | Details |
| 10235287 | Nakamura Y, Yokoyama H, Okamura Y, Ohgo H, Fukuda M, Horie Y, Kato S, Ishii H: Evidence for oxidation by Kupffer cells. Alcohol Clin Exp Res. 1999 Apr;23(4 Suppl):92S-95S. oxidation in Kupffer cells was investigated by measuring 14C- formation from 14C- and the role of aldehyde dehydrogenase 2 (ALDH2) in this process was also examined. formation was significantly attenuated when 20 and 200 microM cyanamide or 2 microM disulfiram were given. |
3(0,0,0,3) | Details |
| 14573760 | DiFabio J, Ji Y, Vasiliou V, Thatcher GR, Bennett BM: Role of mitochondrial aldehyde dehydrogenase in tolerance. Mol Pharmacol. 2003 Nov;64(5):1109-16. To investigate the role of this enzyme in GTN tolerance, cumulative GTN concentration-response curves were obtained for both GTN-tolerant and -nontolerant rat aortic rings treated with the ALDH inhibitor cyanamide or the ALDH substrate The in vivo protocol resulted in almost complete inhibition of ALDH2 activity and GTN biotransformation in hepatic mitochondria, indicating that long-term GTN exposure results in inactivation of the enzyme. |
2(0,0,0,2) | Details |
| 15289380 | Zhang J, Chen Z, Cobb FR, Stamler JS: Role of mitochondrial aldehyde dehydrogenase in nitroglycerin-induced vasodilation of coronary and systemic vessels: an intact canine model. Circulation. 2004 Aug 10;110(6):750-5. Epub 2004 Aug 2. BACKGROUND: It has recently been shown that mitochondrial aldehyde dehydrogenase 2 (mtALDH) catalyzes the formation of 1,2-glyceryl dinitrate and from nitroglycerin (glyceryl trinitrate [GTN]) within mitochondria, leading to production of and vasorelaxation. Each dog was given a 1-mL bolus injection of GTN, sodium nitroprusside (SNP), or through a catheter in the left atrium before and 30 minutes after infusion of cyanamide (17 mg/kg), an inhibitor of mtALDH. |
1(0,0,0,1) | Details |
| 2499314 | Heinstra PW, Geer BW, Seykens D, Langevin M: The metabolism of -derived by alcohol dehydrogenase (EC 1.1.1.1) and aldehyde dehydrogenase (EC 1.2.1.3) in Drosophila melanogaster larvae. Biochem J. 1989 May 1;259(3):791-7. The enzymes, however, showed different inhibition patterns with respect to pyrazole, cyanamide and disulphiram. ALDH-1 and ALDH-2 isoenzymes were detected in larvae by electrophoretic methods. |
1(0,0,0,1) | Details |
| 16554376 | Jung TW, Lee JY, Shim WS, Kang ES, Kim SK, Ahn CW, Lee HC, Cha BS: relieves acute -induced hangover in Sprague-Dawley rats. Alcohol Alcohol. 2006 May-Jun;41(3):231-5. Epub 2006 Mar 22. Levels of aldehyde dehydrogenase 2 (ALD2), involved in an anti-hangover mechanism, were measured by semi-quantitative RT-PCR and western blot analysis. CONCLUSIONS: alleviated the symptoms of -induced hangover by inducing ALD2 expression; this result was reconfirmed by eliminating the effect of by injecting cyanamide, an ALD2 inhibitor. |
1(0,0,0,1) | Details |
| 9667978 | Conway TT, DeMaster EG, Lee MJ, Nagasawa HT: Prodrugs of and nitrosobenzene as cascade latentiated inhibitors of aldehyde dehydrogenase. J Med Chem. 1998 Jul 16;41(15):2903-9. The prototypic aromatic C-nitroso compound, nitrosobenzene (NB), was shown previously to mimic the effect of (HN=O), the putative active metabolite of cyanamide, in inhibiting aldehyde dehydrogenase (AlDH). However, only 7d significantly raised -derived blood levels when administered to rats, a reflection of the inhibition of hepatic mitochondrial AlDH-2. |
1(0,0,0,1) | Details |
| 14690875 | Quintanilla ME, Tampier L: Brain mitochondrial aldehyde dehydrogenase: relation to aversion in low--drinking (UChA) and high--drinking (UChB) rats. Addict Biol. 2003 Dec;8(4):387-97. In experiment 2, the possibility that the inhibition of the brain ALDH2 would lower the AcH aversion threshold in both lines was studied by determining the effect of cyanamide (10 mg/kg i.p.) pretreatment, an inhibitor of ALDH, on AcH aversion, blood AcH levels and brain ALDH2 activity. |
163(2,2,2,3) | Details |
| 10803778 | Yamauchi M, Kimura T, Takeda K, Sakamoto K, Ohata M, Tabe T, Nakano K, Fujiwara S, Takao Y, Toda G: patch test: a simple method for identifying the effectiveness of cyanamide in alcoholics. Alcohol Clin Exp Res. 2000 Apr;24(4 Suppl):39S-42S. BACKGROUND: To identify the pharmacological effectiveness of cyanamide, 144 alcoholics treated with cyanamide were subjected to a test that used an dehydrogenase (ALDH) inhibitor, the patch test, which is considered to be a good indicator of ALDH2 phenotype. |
87(1,1,2,2) | Details |
| 14615007 | Moncada C, Fuentes N, Lladser A, Encina G, Sapag A, Karahanian E, Israel Y: Use of an clamp" in the determination of low-KM aldehyde dehydrogenase activity in H4-II-E-C3 rat hepatoma cells. Alcohol. 2003 Aug-Oct;31(1-2):19-24. We showed that (1) production is linear for 120 min, (2) addition of 160 microM cyanamide to the culture medium leads to a 75%-80% reduction of generated, and (3) ALDH2 activity is dependent on cell-to-cell contact and increases after cells reach confluence. |
86(1,1,1,6) | Details |
| 19576883 | Zhang XJ, Chang L, Zhang YM, Deng S, Li YJ, Peng J: Comparing the role of glutathione-S-transferase and mitochondrial aldehyde dehydrogenase in nitroglycerin biotransformation and the correlation with calcitonin gene-related peptide. Eur J Pharmacol. 2009 Sep 1;617(1-3):97-101. Epub 2009 Jul 2. The inhibitor of GST (ethacrynic acid) or ALDH-2 (cyanamide) was given before nitroglycerin treatment; In vitro, the isolated aorta rings were incubated with nitroglycerin to obtain the concentration-response curve. |
33(0,1,1,3) | Details |
| 12198375 | Fujimiya T, Yamaoka K, Ohbora Y, Aki T, Shinagawa H: Michaelis-Menten elimination kinetics of during oxidation. Alcohol Clin Exp Res. 2002 Aug;26(8 Suppl):49S-54S. The pharmacokinetics of blood AcH during EtOH oxidation was studied with or without the administration of aldehyde dehydrogenase 2 inhibitor (cyanamide) in rabbits. |
32(0,1,1,2) | Details |