Protein Information

Name carbonic anhydrase
Synonyms CA IX; CA1; Carbonic anhydrase I; CA2; CAII; Carbonic anhydrase II; Carbonic dehydratase; Carbonic anhydrase III…

Compound Information

Name chloralose
CAS

Reference List

PubMed Abstract RScore(About this table)
18597935 Wang K, Zheng C, Wu C, Gao M, Liu Q, Yang K, Ellsworth K, Xu L, Wu J: alpha-Chloralose diminishes gamma oscillations in rat hippocampal slices. Neurosci Lett. 2008 Aug 15;441(1):66-71. Epub 2008 Jun 8.

In the present study, we performed electrophysiological recordings to examine the effects of alpha-chloralose on synaptic transmission, tetanic stimulation-induced gamma oscillations (30-80 Hz) and neuronal receptor function in rat hippocampal slices and dissociated hippocampal CA1 pyramidal neurons.
112(1,2,2,2) Details
11711575 Teppema LJ, Dahan A, Olievier CN: Low-dose acetazolamide reduces CO (2)-O (2) stimulus interaction within the peripheral chemoreceptors in the anaesthetised cat. J Physiol. 2001 Nov 15;537(Pt 1):221-9.

Using the technique of end-tidal CO (2) forcing, we measured the effect of the carbonic anhydrase inhibitor acetazolamide (4 mg kg (-1), I.V.) on the CO (2) sensitivities of the peripheral and central chemoreflex loops both during hyperoxia and hypoxia in 10 cats anaesthetised with alpha-chloralose-urethane. 2.
32(0,1,1,2) Details
1816381 Coates EL, Li AH, Nattie EE: Acetazolamide on the ventral medulla of the cat increases phrenic output and delays the ventilatory response to CO2. J Physiol. 1991 Sep;441:433-51.

Acetazolamide (0.1 mM) applied to the surface of the rostral ventrolateral medulla or microinjected beneath the medullary surface in chloralose-urethane-anaesthetized, vagotomized, carotid-denervated, paralysed, servo-ventilated cats produced a long-lasting increase in integrated phrenic nerve activity. 2.
Medullary carbonic anhydrase inhibition reduced the slope and the half-time of the phrenic response to rapid step CO2 increases.
3(0,0,0,3) Details
12611760 Solomon IC: Focal CO2/H+ alters phrenic motor output response to chemical stimulation of cat pre-Botzinger complex in vivo. J Appl Physiol. 2003 Jun;94(6):2151-7. Epub 2003 Feb 28.

Therefore, we examined the effects of unilateral microinjection of DLH (10 mM; 10-20 nl) into the pre-BotC before and during increased focal pre-BotC CO (2)/H (+) (i.e., focal tissue acidosis) in chloralose-anesthetized, vagotomized, mechanically ventilated cats.
Focal tissue acidosis was produced by blockade of carbonic anhydrase with either focal acetazolamide (AZ) or methazolamide (MZ) microinjection.
1(0,0,0,1) Details
8576866 Teppema L, Berkenbosch A, DeGoede J, Olievier C: Carbonic anhydrase and control of breathing: different effects of benzolamide and methazolamide in the anaesthetized cat. J Physiol. 1995 Nov 1;488 ( Pt 3):767-77.

The effect of inhibition of erythrocyte carbonic anhydrase on the ventilatory response to CO2 was studied by administering benzolamide (70 mg kg-1, i.v.), an inhibitor which does not cross the blood-brain barrier, to carotid body denervated cats which were anaesthetized with chloralose-urethane. 2.
6(0,0,0,6) Details
8462002 Maktabi MA, Stachovic GC, Faraci FM: Angiotensin II decreases the rate of production of cerebrospinal fluid. Brain Res. 1993 Mar 19;606(1):44-9.

To test the specificity of saralasin in blocking effects of angiotensin II receptor stimulation on CSF production, the carbonic anhydrase inhibitor acetazolamide was administered in the presence and absence of saralasin.(ABSTRACT TRUNCATED AT 250 WORDS)
Production of CSF was measured in chloralose-anesthetized rabbits using ventriculocisternal perfusion of artificial CSF containing blue dextran.
1(0,0,0,1) Details
10846011 Solomon IC, Edelman NH, O'Neal MH 3rd: CO (2)/H (+) chemoreception in the cat pre-Botzinger complex in vivo. J Appl Physiol. 2000 Jun;88(6):1996-2007.

We examined the effects of focal tissue acidosis in the pre-Botzinger complex (pre-BotC; the proposed locus of respiratory rhythm generation) on phrenic nerve discharge in chloralose-anesthetized, vagotomized, paralyzed, mechanically ventilated cats.
Focal tissue acidosis was produced by unilateral microinjection of 10-20 nl of the carbonic anhydrase inhibitors acetazolamide (AZ; 50 microM) or methazolamide (MZ; 50 microM).
1(0,0,0,1) Details