| Name | aldose reductase |
|---|---|
| Synonyms | ADR; ALDR 1; ALDR1; Aldehyde reductase; AKR1B1; AKR1B1 protein; AR; Aldehyde reductase 1… |
| Name | cyanamide |
|---|---|
| CAS | cyanamide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7159468 | Hellstrom E, Tottmar O: Effects of aldehyde dehydrogenase inhibitors on enzymes involved in the metabolism of biogenic aldehydes in rat liver and brain. Biochem Pharmacol. 1982 Dec 1;31(23):3899-905. The effects of the aldehyde dehydrogenase inhibitors disulfiram, coprine and cyanamide on enzymes involved in the metabolism of biogenic aldehydes in rat liver and brain were studied. None of the drugs caused any changes in the activities of aldehyde reductase and monoamine oxidase in brains in vivo. |
2(0,0,0,2) | Details |
| 11583712 | Srivastava S, Conklin DJ, Liu SQ, Prakash N, Boor PJ, Srivastava SK, Bhatnagar A: Identification of biochemical pathways for the metabolism of oxidized low-density lipoprotein derived -4- trans-2-nonenal in vascular smooth muscle cells. Atherosclerosis. 2001 Oct;158(2):339-50. The formation of HNA was inhibited by cyanamide, indicating that the acid is derived from an aldehyde dehydrogenase (ALDH)-catalyzed pathway. The formation of GS-DHN appears to be due aldose reductase (AR)-catalyzed reduction of glutathionyl 4-hydroxynonanal (GS-HNE), since inhibitors of AR (tolrestat or sorbinil) prevented GS-DHN formation, and increased the fraction of the conjugate remaining as GS-HNE. |
1(0,0,0,1) | Details |
| 12766072 | Choudhary S, Srivastava S, Xiao T, Andley UP, Srivastava SK, Ansari NH: Metabolism of lipid derived in human lens epithelial cells and rat lens. Invest Ophthalmol Vis Sci. 2003 Jun;44(6):2675-82. Sorbinil, an aldose reductase (AR) inhibitor, attenuated GS-DHN levels and cyanamide, an aldehyde dehydrogenase inhibitor, decreased formation of HNA. |
1(0,0,0,1) | Details |
| 9556565 | Srivastava S, Chandra A, Wang LF, Seifert WE Jr, DaGue BB, Ansari NH, Srivastava SK, Bhatnagar A: Metabolism of the lipid peroxidation product, 4--trans-2-nonenal, in isolated perfused rat heart. J Biol Chem. 1998 May 1;273(18):10893-900. Further metabolism of the GS-HNE conjugate involves aldose reductase-mediated reduction, a reaction catalyzed in vitro by homogenous cardiac aldose reductase. When exposed to sorbinil, an inhibitor of aldose reductase, no GS-DHN was recovered in the coronary effluent, and treatment with cyanamide, an inhibitor of aldehyde dehydrogenase, attenuated 4-hydroxy-2-nonenoic acid formation. |
1(0,0,0,1) | Details |
| 11033416 | Srivastava S, Dixit BL, Cai J, Sharma S, Hurst HE, Bhatnagar A, Srivastava SK: Metabolism of lipid peroxidation product, (HNE) in rat erythrocytes: role of aldose reductase. Free Radic Biol Med. 2000 Oct 1;29(7):642-51. Inhibitors of or alcohol dehydrogenase, i.e., cyanamide and 4-methyl pyrazole, had no effect on the formation of HNA and GS-DHN, indicating that these enzymes are not significant participants in the erythrocyte HNE metabolism. |
3(0,0,0,3) | Details |