Protein Information

Name contractile protein
Synonyms Contractile protein; ID2B

Compound Information

Name cyanamide
CAS cyanamide

Reference List

PubMed Abstract RScore(About this table)
7662040 Marway JS, Preedy VR: The acute effects of ethanol and acetaldehyde on the synthesis of mixed and contractile proteins of the jejunum. Alcohol Alcohol. 1995 Mar;30(2):211-7.

The greatest reductions in ks of mixed and contractile proteins occurred with cyanamide pretreatment followed by ethanol treatment; mixed and contractile protein ks in the cyanamide plus ethanol group decreased by approximately 60% when compared with saline plus saline and cyanamide plus saline groups, whereas ks decreased by approximately 45% when compared with the saline plus ethanol injected group.
7(0,0,1,2) Details
8453736 Siddiq T, Richardson PJ, Mitchell WD, Teare J, Preedy VR: Ethanol-induced inhibition of ventricular protein synthesis in vivo and the possible role of acetaldehyde. Cell Biochem Funct. 1993 Mar;11(1):45-54.

Two metabolic inhibitors of ethanol metabolism were also used namely 4-methylpyrazole (alcohol dehydrogenase inhibitor) and cyanamide (acetaldehyde dehydrogenase inhibitor) which in ethanol-dosed rats have been shown to either decrease or increase acetaldehyde formation, respectively.
The results showed that ethanol alone and ethanol plus 4-methylpyrazole decreased the fractional rates of mixed, myofibrillar (contractile) and sarcoplasmic (non-contractile) protein synthesis to the same extent (by approx. 25 per cent).
1(0,0,0,1) Details