| Name | nNOS |
|---|---|
| Synonyms | Constitutive NOS; NOS1; IHPS 1; IHPS1; N NOS; NC NOS; NOS; NOS type I… |
| Name | chloralose |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9390651 | Cholet N, Seylaz J, Lacombe P, Bonvento G: Local uncoupling of the cerebrovascular and metabolic responses to somatosensory stimulation after neuronal synthase inhibition. J Cereb Blood Flow Metab. 1997 Nov;17(11):1191-201. To address these issues, we analyzed the combined circulatory and metabolic consequences of inhibiting the nNOS both at rest and during functional activation in the rat anesthetized with alpha-chloralose. |
83(1,1,1,3) | Details |
| 16883353 | Stefanovic B, Schwindt W, Hoehn M, Silva AC: Functional uncoupling of hemodynamic from neuronal response by inhibition of neuronal synthase. J Cereb Blood Flow Metab. 2007 Apr;27(4):741-54. Epub 2006 Aug 2. The cerebrovascular coupling under neuronal synthase (nNOS) inhibition was investigated in alpha-chloralose anesthetized rats. |
81(1,1,1,1) | Details |
| 9806812 | Zagvazdin Y, Sancesario G, Fitzgerald ME, Reiner A: Effects of halothane and urethane-chloralose anaesthesia on the pressor and cerebrovascular responses to 7-NITROINDAZOLE, an inhibitor of synthase. Pharmacol Res. 1998 Nov;38(5):339-46. We examined the effect of 7-nitroindazole (7NI), a reportedly relatively specific inhibitor of the neuronal isoform of synthase (nNOS), on mean arterial blood pressure and on cerebral blood flow in rats under three different types of anaesthesia: urethane-chloralose, halothane, or urethane preceded by induction of anaesthesia with halothane. |
31(0,1,1,1) | Details |
| 11788407 | Li YF, Roy SK, Channon KM, Zucker IH, Patel KP: Effect of in vivo gene transfer of nNOS in the PVN on renal nerve discharge in rats. Am J Physiol Heart Circ Physiol. 2002 Feb;282(2):H594-601. In alpha-chloralose- and urethane-anesthetized rats, microinjection of N (G)-monomethyl- (L-NMMA), a NO antagonist, into the PVN produced a dose-dependent increase in RSND, blood pressure, and heart rate. |
4(0,0,0,4) | Details |
| 9486242 | Meng W, Ayata C, Waeber C, Huang PL, Moskowitz MA: Neuronal NOS--dependent -induced relaxation in pial arterioles of endothelial NOS knockout mice. Am J Physiol. 1998 Feb;274(2 Pt 2):H411-5. We evaluated the effects of superfusing 1H-[1,2,4] oxadiazolo [4,3-a] quinoxalin-1-one (ODQ), eNOS null (B) an inhibitor of soluble guanylyl cyclase, and 7-nitroindazole (7-NI), a selective neuronal synthase (nNOS) inhibitor, on the response in endothelial NOS (eNOS) null mice. Pial arteriolar diameter was measured by intravital microscopy through a closed cranial window under alpha-chloralose anesthesia. |
2(0,0,0,2) | Details |
| 10867178 | Bonvento G, Cholet N, Seylaz J: Sustained attenuation of the cerebrovascular response to a 10 min whisker stimulation following neuronal synthase inhibition. Neurosci Res. 2000 Jun;37(2):163-6. We examined the effect of type I synthase (neuronal isoform of NOS, nNOS) inhibition on the temporal profile of the cortical blood flow (CoBF) changes induced by a relatively long period (10 min) of whisker stimulation. To address this issue, we used laser-Doppler flowmetry (LDF) to continuously monitor the CoBF in rats anesthetized with alpha-chloralose, in a control condition, and 30 and 60 min following 7-nitroindazole (25 mg/kg, i.p.). |
2(0,0,0,2) | Details |
| 11514264 | Zhang K, Li YF, Patel KP: Blunted -mediated inhibition of renal nerve discharge within PVN of rats with heart failure. Am J Physiol Heart Circ Physiol. 2001 Sep;281(3):H995-1004. We have demonstrated a decreased neuronal (NO) synthase (nNOS) message in the hypothalamus of rats with heart failure (HF). In alpha-chloralose- and urethane-anesthetized rats, an inhibitor of NO synthase, N (G)-monomethyl- (L-NMMA) microinjected into the PVN (50, 100, and 200 pmol in 50-200 nl) produced a dose-dependent increase in RSND, blood pressure, and heart rate in control and HF rats. |
2(0,0,0,2) | Details |
| 16322352 | Zheng H, Mayhan WG, Bidasee KR, Patel KP: Blunted -mediated inhibition of sympathetic nerve activity within the paraventricular nucleus in diabetic rats. Am J Physiol Regul Integr Comp Physiol. 2006 Apr;290(4):R992-R1002. Epub 2005 Dec 1. Diabetic rats were found to have significantly fewer nNOS positive cells in the PVN than in the control group (120 +/- 11 vs. 149 +/- 13, P < 0.05). In alpha-chloralose- and urethane-anesthetized rats, an inhibitor of NO synthase, l-NMMA, microinjected into the PVN produced a dose-dependent increase in RSNA, mean arterial pressure (MAP), and heart rate (HR) in both control and diabetic rats. |
2(0,0,0,2) | Details |
| 16239274 | Bagnall NM, Dent PC, Walkowska A, Sadowski J, Johns EJ: inhibition and the impact on renal nerve-mediated antinatriuresis and antidiuresis in the anaesthetized rat. J Physiol. 2005 Dec 15;569(Pt 3):849-56. Epub 2005 Oct 20. The contribution of (NO) to the antinatriuresis and antidiuresis caused by low-level electrical stimulation of the renal sympathetic nerves (RNS) was investigated in rats anaesthetized with chloralose-urethane. These data demonstrated that the renal nerve-mediated antinatriuresis and antidiuresis was dependent on the presence of NO, generated in part by nNOS. |
1(0,0,0,1) | Details |
| 17064669 | Fletcher J, Moody WE, Chowdhary S, Coote JH: NO-cGMP pathway at ventrolateral medullary cardiac inhibitory sites enhances the baroreceptor reflex bradycardia in the rat. Brain Res. 2006 Dec 6;1123(1):125-34. Epub 2006 Oct 24. The neuronal isoform of the enzyme synthase (nNOS) has been identified in the caudal ventrolateral medulla of the rat close to the location of cardiac vagal motoneurones. In rats anaesthetised with a mixture of urethane (650 mg kg (-1)) and chloralose (50 mg kg (-1)) i.v., blood pressure and heart rate were monitored continuously and using stereotaxic coordinates the ventrolateral caudal brainstem within and around the nucleus ambiguus was systematically explored for sites producing a bradycardia of > 50 bpm, without a change in blood pressure, using D,L homocysteic acid (DLH, 0.2 M) microinjections (50 nl) from a glass micropipette. |
1(0,0,0,1) | Details |
| 15795177 | Ma R, Zhu GQ, Wang W: Interaction of central Ang II and NO on the cardiac sympathetic afferent reflex in dogs. Auton Neurosci. 2005 Mar 31;118(1-2):51-60. All dogs were anesthetized with alpha-chloralose (100 mg/kg, iv). |
0(0,0,0,0) | Details |