| Name | 5 HT2 |
|---|---|
| Synonyms | 5 HT 2; 5 HT 2A; 5 HT2; 5 HT2A; 5 hydroxytryptamine (serotonin) receptor 2A; 5 hydroxytryptamine 2A receptor; 5 hydroxytryptamine receptor 2A; HTR 2… |
| Name | chloralose |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10694218 | Knowles ID, Ramage AG: Evidence that activation of central 5-HT (2B) receptors causes renal sympathoexcitation in anaesthetized rats. Br J Pharmacol. 2000 Jan;129(1):177-83. The effects of injections i.c.v. of alpha-methyl-5-(2-thienylmethoxy)- (BW723C86; 0.02 - 2 micromol kg (-1)), a 5-HT (2B) receptor agonist, on renal sympathetic and phrenic nerve activity, mean arterial blood pressure and heart rate were investigated in alpha-chloralose anaesthetized rats pretreated with a peripherally acting 5-HT (2) receptor antagonist. |
31(0,1,1,1) | Details |
| 8528555 | Anderson IK, Martin GR, Ramage AG: Evidence that activation of 5-HT2 receptors in the forebrain of anaesthetized cats causes sympathoexcitation. Br J Pharmacol. 1995 Sep;116(2):1751-6. Cats were anaesthetized with a mixture of alpha-chloralose and pentobarbitone neuromuscularly blocked and artifically ventilated. |
5(0,0,0,5) | Details |
| 1797303 | Shepheard SL, Jordan D, Ramage AG: Investigation of the effects of IVth ventricular administration of the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), on autonomic outflow in the anaesthetized cat. Br J Pharmacol. 1991 Oct;104(2):367-72. The effects of IVth ventricular injections of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on renal, splanchnic and cardiac sympathetic nerve activities, phrenic nerve activity, arterial blood pressure, heart rate, femoral arterial conductance, tracheal and intragastric pressures were investigated in alpha-chloralose anaesthetized, neuromuscular blocked and artificially ventilated cats. 2. |
3(0,0,0,3) | Details |
| 8761843 | Nearing BD, Hutter JJ, Verrier RL: Potent antifibrillatory effect of combined blockade of channels and 5-HT2 receptors with nexopamil during myocardial ischemia and reperfusion in dogs: comparison to J Cardiovasc Pharmacol. 1996 Jun;27(6):777-87. The effect of nexopamil was tested during a 10-min period of left anterior descending (LAD) coronary artery occlusion and release in chloralose-anesthetized dogs. |
3(0,0,0,3) | Details |
| 15197536 | Lambert GA, Donaldson C, Hoskin KL, Boers PM, Zagami AS: Dilatation induced by in the middle meningeal artery of the anaesthetised cat. Naunyn Schmiedebergs Arch Pharmacol. 2004 Jun;369(6):591-601. Epub 2004 May 7. In chloralose-anaesthetised cats, we studied the effects of intravenous and intra-carotid injections of on the middle meningeal artery and the way these were modified by antagonists. Intravenous injections of 5-HT, 2-50 microg kg (-1) (5.2-129 nmole kg (-1)), produced a dose-dependent fall in blood pressure, a rise in meningeal blood flow, and an associated fall in middle meningeal resistance. |
1(0,0,0,1) | Details |
| 16973701 | Madden CJ, Morrison SF: potentiates sympathetic responses evoked by spinal . J Physiol. 2006 Dec 1;577(Pt 2):525-37. Epub 2006 Sep 14. In urethane-chloralose anaesthetized, neuromuscularly blocked, ventilated rats, we examined the effects on sympathetic outflow to brown adipose tissue (BAT) of separate and simultaneous spinal microinjections of and Microinjection of (5-HT, 2 nmol) into the T4 IML increased BAT SNA (peak: +342% of control) at a long latency (mean onset: 23 min). |
1(0,0,0,1) | Details |
| 1888993 | Hill JM, Kaufman MP: Intrathecal attenuates the pressor response to static contraction. Brain Res. 1991 May 31;550(1):157-60. We tested the hypothesis that intrathecal injection of onto the lumbosacral spinal cord of chloralose-anesthetized cats attenuates the pressor response to static contraction of the triceps surae muscles. |
0(0,0,0,0) | Details |
| 9087599 | Sevoz C, Callera JC, Machado BH, Hamon M, Laguzzi R: Role of serotonin3 receptors in the nucleus tractus solitarii on the carotid chemoreflex. Am J Physiol. 1997 Mar;272(3 Pt 2):H1250-9. The chemoreflex responses were triggered by an intravenous administration of KCN (40 microg/kg) in spontaneously breathing urethan-chloralose-anesthetized rats or by an intracarotid administration of saline saturated with 100% CO2 in pancuronium bromide-paralyzed and artificially ventilated urethan-anesthetized rats. |
0(0,0,0,0) | Details |
| 18082230 | Madden CJ, Morrison SF: Brown adipose tissue sympathetic nerve activity is potentiated by activation of (5-HT) 1A/5-HT7 receptors in the rat spinal cord. Neuropharmacology. 2008 Mar;54(3):487-96. Epub 2007 Nov 5. In urethane-chloralose anesthetized, neuromuscularly blocked, ventilated rats, microinjection of (12 pmol) into the right fourth thoracic segment (T4) spinal intermediolateral nucleus (IML) immediately increased ipsilateral brown adipose tissue (BAT) sympathetic nerve activity (SNA; peak +492% of control), expired CO2 (+0.1%) heart rate (+48 beats min (-1)) and arterial pressure (+8 mmHg). |
0(0,0,0,0) | Details |
| 10516629 | Knowles ID, Ramage AG: Evidence for a role for central 5-HT2B as well as 5-HT2A receptors in cardiovascular regulation in anaesthetized rats. Br J Pharmacol. 1999 Oct;128(3):530-42. The effects of injections i.c.v. of quipazine, (2 micromol kg-1) and 1-(2,5-di-methoxy-4-iodophenyl)-2-aminopropane (DOI; 2 micromol kg-1) on renal sympathetic and phrenic nerve activity, mean arterial blood pressure (MAP) and heart rate were investigated in alpha-chloralose anaesthetized rats pretreated with a peripherally acting 5-HT2 receptor antagonist. 2. |
35(0,1,1,5) | Details |
| 8436806 | Ramage AG, Shepheard SL, Jordan D, Koss MC: Can the 5-HT2/1c agonist DOI cause differential sympatho-excitation in nerves supplying the heart in anaesthetized cats?. J Auton Nerv Syst. 1993 Jan;42(1):53-62. A comparison of the effects on sympathetic nerve activity to the heart of intravenous administration of the selective 5-HT2/1c agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) alone and in the presence of the peripherally acting 5-HT2/1c antagonist BW501C67 were made in alpha-chloralose anaesthetized cats. |
33(0,1,1,3) | Details |
| 9680249 | Bootle DJ, Adcock JJ, Ramage AG: The role of central receptors in the bronchoconstriction evoked by inhaled in anaesthetised guinea-pigs. Neuropharmacology. 1998;37(2):243-50. The effects of intracisternal (i.c) injections of the 5-HT1A receptor agonists, and 8-OH-DPAT, and the antagonists WAY-100635; and (-)-pindolol, the 5-HT1B/1D receptor agonist and antagonist GR127935, the 5-HT2 receptor agonist DOI and the antagonist cinanserin, the 5-HT3 receptor antagonist granisetron, the alpha-adrenoceptor agonist clonidine and the antagonist idazoxan, the D2 receptor antagonists (-)-sulpiride and the uptake inhibitor fluoxetine on -evoked increase in tracheal inflation pressure (bronchoconstriction) were investigated in alpha-chloralose anaesthetised, neuromuscularly blocked, artificially ventilated guinea-pigs. |
32(0,1,1,2) | Details |
| 8646420 | Bootle DJ, Adcock JJ, Ramage AG: Involvement of central 5-HT1A receptors in the reflex activation of pulmonary vagal motoneurones by inhaled in anaesthetized cats. Br J Pharmacol. 1996 Feb;117(4):724-8. This was carried out by investigating the effects of intracisternal injections (i.c.) of the 5-HT1A receptor ligands, 8-OH-DPAT (50 micrograms kg-1), (200 micrograms kg-1), WAY-100635 (100 micrograms kg-1), methiothepin (200 micrograms kg-1) and (-)-pindolol (100 micrograms kg-1) and the 5-HT2 receptor antagonist, cinanserin (200 micrograms kg-1), on the reflex bronchoconstriction evoked by inhaled aerosol in alpha-chloralose anaesthetized, neuromuscularly blocked and artificially ventilated cats. |
31(0,1,1,1) | Details |
| 1467825 | Anderson IK, Martin GR, Ramage AG: Central administration of activates 5-HT1A receptors to cause sympathoexcitation and 5-HT2/5-HT1C receptors to release in anaesthetized rats. Br J Pharmacol. 1992 Dec;107(4):1020-8. The effects of intracerebroventricular injections to the right lateral ventricle (i.c.v.) of 40 and 120 nmol kg-1), N,N-di-n-propyl-5-carboxamidotryptamine (DP-5-CT; 3 nmol kg-1), 5-carboxamidotryptamine (5-CT; 3 nmol kg-1), 8--2-(di-N-propylamino) tetralin (8-OH-DPAT; 3, 40 and 120 nmol kg-1) and 1-(2,5-di-methoxy-4-iodophenyl)-2-aminopropane (DOI; 40 and 120 nmol kg-1) on renal sympathetic nerve activity, blood pressure, heart rate and phrenic nerve activity were investigated in normotensive rats anaesthetized with alpha-chloralose. 2. caused a long lasting pressor response which was associated with an initial bradycardia and renal sympathoinhibition followed by a tachycardia and renal sympathoexcitation. |
4(0,0,0,4) | Details |
| 8097247 | Krowicki ZK, Hornby PJ: microinjected into the nucleus raphe obscurus increases intragastric pressure in the rat via a vagally mediated pathway. J Pharmacol Exp Ther. 1993 Apr;265(1):468-76. The purpose of the present study was to investigate the effect of microinjection of and selected receptor subtype agonists and antagonists into the caudal nucleus raphe obscurus on gastrointestinal motor activity in urethane-chloralose anesthetized rats. The gastric excitatory effect of (6.0 nmol) was markedly reduced by prior microinjection of a 5-HT1/2 receptor antagonist, methiothepin (200 nmol), into the same site, as well as by i.v. administration of a 5-HT2/1C antagonist, ketanserin (2.5 mg/kg). |
1(0,0,0,1) | Details |
| 8032949 | Kishimoto T, Yamanaka T, Amano T, Todo N, Sasa M: 5-HT1A receptor-mediated inhibition of lateral vestibular nucleus neurons projecting to the abducens nucleus. Brain Res. 1994 Apr 25;644(1):47-51. Electrophysiological studies were performed using cats anesthetized with alpha-chloralose, to elucidate the receptor subtypes involved in the -induced inhibition of the lateral vestibular nucleus (LVN) neurons projecting to or through the abducens nucleus. Microiontophoretically applied 1-(3-chlorophenyl) piperazine (mCPP), a 5-HT1B agonist inhibited the orthodromic spike elicited by vestibular nerve stimulation and -induced firing in only a small number of the LVN neurons. 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), a 5-HT2 agonist, rarely affected these neurons. |
1(0,0,0,1) | Details |
| 8004405 | Shepheard SL, Jordan D, Ramage AG: Comparison of the effects of IVth ventricular administration of some analogues with those of 8-OH-DPAT on autonomic outflow in the anaesthetized cat. Br J Pharmacol. 1994 Feb;111(2):616-24. Further, brainstem 5-HT1A receptors play an important role in the control of renal sympathetic outflow while brainstem 5-HT2 receptors are involved in the control of skeletal muscle and/or skin blood flow. 1 The present study compares the effects on representative autonomic outflows of IVth ventricular application of analogues which act at 5-HT1 receptors with 8--2-(di-n-propylamino) tetralin (8-OH-DPAT). 2 Cumulative doses of 8-OH-DPAT, N,N-di-n-propyl-5-carboxamidotryptamine (DP-5-CT) and 5-carboxamidotryptamine (5-CT, 2.5-40 nmol kg-1), (10-160 nmol kg-1), indorenate (100-800 nmol kg-1), 20-640 nmol kg-1) both alone and in the presence of cinanserin (0.1 mg kg-1) were given into the IVth ventricle of cats which were anaesthetized with a mixture of alpha-chloralose and pentobarbitone neuromuscularly blocked and artificially ventilated. |
1(0,0,0,1) | Details |