| Name | angiotensin II |
|---|---|
| Synonyms | AGT; ANG II; ANHU; Angiotensin I; Angiotensin II; Angiotensinogen; Angiotensinogen precursor; SERPINA 8… |
| Name | chloralose |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19880539 | Houghton BL, Huang C, Johns EJ: Influence of dietary on the blood pressure and renal sympathetic nerve activity responses to intracerebroventricular angiotensin II and angiotensin III in anaesthetized rats. Exp Physiol. 2010 Feb;95(2):282-95. Epub 2009 Oct 30. This study compared the mean arterial pressure (MAP) and renal sympathetic nerve activity (RSNA) responses to intracerebroventricular (i.c.v.) infusion of angiotensin II (AngII) and III (AngIII) before and after peripheral V (1) receptor blockade (V (1) B) in alpha-chloralose-urethane-anaesthetized rats fed a low (0.03%, LNa (+)), normal (0.3%, NNa (+)) or high Na (+) diet (3.0%, HNa (+)) from 4 to 11 weeks of age. |
32(0,1,1,2) | Details |
| 19749166 | McClure JM, Rossi NF, Chen H, O'Leary DS, Scislo TJ: is a major vasoconstrictor involved in hindlimb vascular responses to stimulation of A (1) receptors in the nucleus of the solitary tract. Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1661-72. Epub 2009 Sep 11. In urethane-chloralose anesthetized rats we compared the integral changes in iliac vascular conductance evoked by microinjections into the NTS of the selective A (1) receptor agonist N (6)-cyclopentyladenosine (CPA; 330 pmol in 50 nl) in intact (Int) animals and following: V (1) receptor blockade (VX), angiotensin II AT (1) receptor blockade (ATX), bilateral adrenalectomy + ganglionic blockade (ADX + GX; which eliminated the potential increases in circulating norepinephrine and epinephrine), ADX + GX + VX and ADX + GX + VX + ATX. |
32(0,1,1,2) | Details |
| 9453348 | Diz DI, Westwood B, Bosch SM, Ganten D, Ferrario C: NK1 receptor antagonist blocks angiotensin II responses in renin transgenic rat medulla oblongata. Hypertension. 1998 Jan;31(1 Pt 2):473-9. Injections of Ang II (250 fmol in 30 nL) into the nTS of chloralose-urethane anesthetized TG rats produced a significant increase in pressure of 7+/-2 mm Hg before a 13+/-3 mm Hg fall in pressure. |
13(0,0,1,8) | Details |
| 8462002 | Maktabi MA, Stachovic GC, Faraci FM: Angiotensin II decreases the rate of production of cerebrospinal fluid. Brain Res. 1993 Mar 19;606(1):44-9. Production of CSF was measured in chloralose-anesthetized rabbits using ventriculocisternal perfusion of artificial CSF containing blue dextran. |
9(0,0,0,9) | Details |
| 12621527 | Moosavi SM, Johns EJ: The effect of isoprenaline infusion on renal renin and angiotensinogen gene expression in the anaesthetised rat. Exp Physiol. 2003 Mar;88(2):221-7. In this study, we investigated the ability of acute infusions of isoprenaline to alter renin and angiotensinogen gene expression in the kidney of rats anaesthetised with chloralose-urethane. |
9(0,0,1,4) | Details |
| 8023367 | Maktabi MA, Faraci FM: Endogenous angiotensin II inhibits production of cerebrospinal fluid during posthypoxemic reoxygenation in the rabbit. Stroke. 1994 Jul;25(7):1489-93; discussion 1494. METHODS: We measured production of CSF in chloralose-anesthetized rabbits using ventriculocisternal perfusion of artificial CSF containing blue dextran. |
9(0,0,0,9) | Details |
| 12754082 | Katsunuma N, Tsukamoto K, Ito S, Kanmatsuse K: Enhanced angiotensin-mediated responses in the nucleus tractus solitarii of spontaneously hypertensive rats. Brain Res Bull. 2003 May 15;60(3):209-14. In alpha-chloralose-anesthetized Sprague-Dawley (S-D) rats, Wistar-Kyoto (WKY) rats, and SHR, unilateral injection of Ang II into the NTS decreased arterial pressure (AP) and heart rate (HR). |
8(0,0,1,3) | Details |
| 19506098 | Capone C, Anrather J, Milner TA, Iadecola C: Estrous cycle-dependent neurovascular dysfunction induced by angiotensin II in the mouse neocortex. Hypertension. 2009 Aug;54(2):302-7. Epub 2009 Jun 8. Cerebral blood flow was monitored by laser-Doppler flowmetry in anesthetized (urethane-chloralose) C57BL/6 female mice equipped with a cranial window. |
8(0,0,0,8) | Details |
| 1467940 | Chodobski A, Szmydynger-Chodobska J, Segal MB, McPherson IA: The role of angiotensin II in regulation of cerebrospinal fluid formation in rabbits. Brain Res. 1992 Oct 23;594(1):40-6. The effect of central and peripheral administrations of angiotensin II (AII) on cerebrospinal fluid (CSF) formation was investigated in rabbits anesthetized with intravenous alpha-chloralose and urethane. |
7(0,0,1,2) | Details |
| 16153615 | Han Y, Zhang Y, Wang HJ, Gao XY, Wang W, Zhu GQ: Reactive species in paraventricular nucleus modulates cardiac sympathetic afferent reflex in rats. Brain Res. 2005 Oct 5;1058(1-2):82-90. Epub 2005 Sep 8. Our previous studies showed that angiotensin II (Ang II) in the paraventricular nucleus (PVN) potentiated the cardiac sympathetic afferent reflex (CSAR) in rats. Under alpha-chloralose and urethane anesthesia, renal sympathetic nerve activity (RSNA), mean arterial pressure (MAP) and heart rate were recorded in sinoaortic-denervated and cervical-vagotomized rats. |
5(0,0,0,5) | Details |
| 8713681 | Chai CY, Chen SY, Lin AM, Tseng CJ: Angiotensin II activates pressor and depressor sites of the pontomedulla that react to Clin Exp Pharmacol Physiol. 1996 May;23(5):415-23. In cats anaesthetized with a mixture of alpha-chloralose (40 mg/kg) and urethane (400 mg/kg) and in rats anaesthetized with a mixture of alpha-chloralose (60 mg/kg) and urethane (800 mg/kg), changes in systemic arterial pressure (SAP), heart rate (HR) and sympathetic activities of vertebral (VNA) and renal (RNA) nerves were determined following the microinjection of angiotensin II (AngII; 0.16 mmol/L; 50 nL) into the pressor and depressor sites of the pontomedulla previously reacted to a microinjection of monosodium 0.1 mol/L; 50 nL). |
7(0,0,1,2) | Details |
| 8764299 | Ito S, Sved AF: Blockade of angiotensin receptors in rat rostral ventrolateral medulla removes excitatory vasomotor tone. Am J Physiol. 1996 Jun;270(6 Pt 2):R1317-23. The present study used bilateral microinjections of angiotensin receptor antagonists into the RVLM of chloralose-anesthetized rats to determine the degree to which tonic blood pressure was dependent upon this angiotensin-mediated input. Bilateral injection into the RVLM of 1 nmol of [Sar1, Thr8] angiotensin II or [Sar1, Ile8] angiotensin II decreased blood pressure approximately 40 mmHg. |
3(0,0,0,3) | Details |
| 16099221 | Wang HJ, Zhang F, Zhang Y, Gao XY, Wang W, Zhu GQ: AT1 receptor in paraventricular nucleus mediates the enhanced cardiac sympathetic afferent reflex in rats with chronic heart failure. Auton Neurosci. 2005 Aug 31;121(1-2):56-63. Exogenous angiotensin II (Ang II) in the paraventricular nucleus (PVN) potentiated this reflex which was mediated by AT1 receptor. Under urethane and alpha-chloralose anesthesia, mean arterial pressure, heart rate and renal sympathetic nerve activity (RSNA) were recorded in sino-aortic denervated and cervical vagotomized CHF and sham-operated rats. |
3(0,0,0,3) | Details |
| 19346334 | Zhu GQ, Xu Y, Zhou LM, Li YH, Fan LM, Wang W, Gao XY, Chen Q: Enhanced cardiac sympathetic afferent reflex involved in sympathetic overactivity in renovascular hypertensive rats. Exp Physiol. 2009 Jul;94(7):785-94. Epub 2009 Apr 3. Furthermore, the role of central angiotensin II type 1 (AT (1)) receptors in mediating the CSAR was determined. Under urethane and alpha-chloralose anaesthesia, the renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP) were recorded in sinoaortic denervated and cervical vagotomized rats. |
2(0,0,0,2) | Details |
| 9321871 | Johansson B, Holm M, Chen L, Pettersson A, Jonson C, Fandriks L: ANG II prolongs splanchnic nerve-mediated inhibition of duodenal mucosal alkaline secretion in the rat. Am J Physiol. 1997 Sep;273(3 Pt 2):R942-6. Experiments were performed on chloralose-anesthetized rats. Intravenous pretreatment with the angiotensin-converting enzyme (ACE) inhibitor enalaprilate (0.7 mg/kg) or the angiotensin II-receptor antagonist losartan (10 mg/kg) altered the response to hypovolemia to a transient one, and alkaline secretion returned to the control level within 40-50 min. |
4(0,0,0,4) | Details |
| 19645750 | Zhong MK, Gao J, Zhang F, Xu B, Fan ZD, Wang W, Zhu GQ: Reactive species in rostral ventrolateral medulla modulate cardiac sympathetic afferent reflex in rats. Acta Physiol. 2009 Dec;197(4):297-304. Epub 2009 Jul 23. AIM: The aim of the present study was to investigate whether reactive species (ROS) in rostral ventrolateral medulla (RVLM) modulate cardiac sympathetic afferent reflex (CSAR) and the enhanced CSAR response caused by microinjection of angiotensin II (Ang II) into the paraventricular nucleus (PVN). METHODS: Under urethane and alpha-chloralose anaesthesia, renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP) were recorded in sinoaortic-denervated and cervical-vagotomized rats. |
3(0,0,0,3) | Details |
| 17085537 | Sakima A, Averill DB, Kasper SO, Jackson L, Ganten D, Ferrario CM, Gallagher PE, Diz DI: Baroreceptor reflex regulation in anesthetized transgenic rats with low glia-derived angiotensinogen. Am J Physiol Heart Circ Physiol. 2007 Mar;292(3):H1412-9. Epub 2006 Nov 3. Arterial baroreceptor reflex sensitivity (BRS) for control of heart rate (HR) in response to increases in mean arterial pressure (MAP) was tested before and after bilateral microinjection of the angiotensin type 1 (AT (1)) receptor blocker candesartan or the ANG-(1-7) receptor blocker (d- (7))-ANG-(1-7) into the NTS of urethane-chloralose-anesthetized ASrAOGEN and SD rats. |
3(0,0,0,3) | Details |
| 8074217 | Wood JG, Yan ZY, Cheung LY: Role of prostaglandins in angiotensin II-induced gastric vasoconstriction. Am J Physiol. 1994 Aug;267(2 Pt 1):G173-9. ANG II produced statistically significant, dose-related increases in vascular resistance of a mechanically perfused ex vivo stomach segment of chloralose-anesthetized dogs. |
2(0,0,0,2) | Details |
| 9435602 | Ma R, Zucker IH, Wang W: Central gain of the cardiac sympathetic afferent reflex in dogs with heart failure. Am J Physiol. 1997 Dec;273(6 Pt 2):H2664-71. This enhanced central gain of the cardiac sympathetic afferent reflex in the heart failure group was significantly attenuated after intravenous and cerebroventricular injection of the angiotensin II receptor antagonist losartan (5 mg/kg i.v. and 0.125 mg/kg in 0.1 ml i.c.v.). At the time of the acute experiment the dogs were anesthetized with alpha-chloralose. |
2(0,0,0,2) | Details |
| 15908469 | Ganta CK, Lu N, Helwig BG, Blecha F, Ganta RR, Zheng L, Ross CR, Musch TI, Fels RJ, Kenney MJ: Central angiotensin II-enhanced splenic cytokine gene expression is mediated by the sympathetic nervous system. Am J Physiol Heart Circ Physiol. 2005 Oct;289(4):H1683-91. Epub 2005 May 20. Experiments were completed in sinoaortic nerve-lesioned, urethane-chloralose-anesthetized, splenic nerve-intact (splenic-intact) and splenic nerve-lesioned (splenic-denervated) Sprague-Dawley rats. |
2(0,0,0,2) | Details |
| 11352819 | Johansson B, Holm M, Ewert S, Casselbrant A, Pettersson A, Fandriks L: Angiotensin II type 2 receptor-mediated duodenal mucosal alkaline secretion in the rat. Am J Physiol Gastrointest Liver Physiol. 2001 Jun;280(6):G1254-60. Immunohistochemistry was used to locate AT (1) and AT (2) receptors in chloralose-anesthetized rats. |
3(0,0,0,3) | Details |
| 1410404 | Chodobski A, Szmydynger-Chodobska J, Segal MB, McPherson IA: Effect of central administration of angiotensin II on cerebrospinal fluid formation in rabbits. Prog Brain Res. 1992;91:19-22. The effect of central administration of AII on CSF formation was studied in alpha-chloralose and urethane anesthetized rabbits using the ventriculocisternal perfusion method. |
1(0,0,0,1) | Details |
| 16100243 | McClure JM, O'Leary DS, Scislo TJ: Stimulation of NTS A1 receptors evokes counteracting effects on hindlimb vasculature. Am J Physiol Heart Circ Physiol. 2005 Dec;289(6):H2536-42. Epub 2005 Aug 12. After bilateral adrenalectomy plus lumbar sympathectomy, a marked vasoconstriction in iliac vascular bed still persisted, suggesting that the vasoconstrictor component of the response to stimulation of NTS A1 receptors is mediated mostly via circulating factors (e.g., angiotensin II, or circulating catecholamines released from other sympathetic terminals). Therefore, in chloralose-urethane-anesthetized rats, we evaluated the contribution of vasodilator versus vasoconstrictor effects of stimulation of NTS A1 receptors on the hindlimb vasculature. |
1(0,0,0,1) | Details |
| 9313940 | Chu ZM, Beilin LJ: Demonstration of the existence of -independent as well as -dependent vasodilator mechanisms in the in situ renal circulation in near term pregnant rats. Br J Pharmacol. 1997 Sep;122(2):307-15. We have investigated the role of endogenous on renal vascular reactivity in late pregnancy in in situ blood perfused kidneys of alpha-chloralose anaesthetized Wistar-Kyoto rats. |
0(0,0,0,0) | Details |
| 15795177 | Ma R, Zhu GQ, Wang W: Interaction of central Ang II and NO on the cardiac sympathetic afferent reflex in dogs. Auton Neurosci. 2005 Mar 31;118(1-2):51-60. The aim of this study was to test the hypothesis that the central angiotensin II (Ang II) and (NO) systems interact to modulate the cardiac sympathetic afferent reflex (CSAR). All dogs were anesthetized with alpha-chloralose (100 mg/kg, iv). |
2(0,0,0,2) | Details |
| 10744346 | Huang C, Johns EJ: Role of brain angiotensin II in the somatosensory induced antinatriuresis in the anaesthetized rat. Clin Exp Pharmacol Physiol. 2000 Mar;27(3):191-6. In chloralose-urethane-anaesthetized rats receiving saline i.c.v. (2 microL + 1 microL/h), the administration of (0.5 mg, s.c.) increased blood pressure by 14% (P < 0.001) and, while renal perfusion pressure was regulated at an unchanged level, neither renal blood flow (RBF) nor glomerular filtration rate was changed. |
2(0,0,0,2) | Details |
| 20065145 | Bardgett ME, McCarthy JJ, Stocker SD: Glutamatergic receptor activation in the rostral ventrolateral medulla mediates the sympathoexcitatory response to hyperinsulinemia. Hypertension. 2010 Feb;55(2):284-90. Epub 2010 Jan 11. Hyperinsulinemic-euglycemic clamps were performed in alpha-chloralose anesthetized, male Sprague-Dawley rats by infusion of insulin (3.75 mU/kg per minute, IV) and 50% solution for 120 minutes. |
0(0,0,0,0) | Details |
| 8003279 | Abraham G, Simon G: Autopotentiation of pressor responses by subpressor angiotensin II in rats. Am J Hypertens. 1994 Mar;7(3):269-75. Pressor responses to incremental doses of ANG II, (NE), and were measured in chloralose-anesthetized rats, before and after neurohumoral blockade, and the main findings were confirmed in awake, free-moving rats with implanted catheters. |
2(0,0,0,2) | Details |
| 11695707 | Molinari C, Battaglia A, Grossini E, Mary DA, Ruggeri P, Surico N, Vacca G, Vassanelli C: The role of activation of the renin-angiotensin system on the reflex regional vasoconstriction caused by distension of the uterus in anaesthetized pigs. Auton Neurosci. 2001 Oct 8;93(1-2):56-64. In pigs anaesthetized with alpha-chloralose, blood flow in the left circumflex or anterior descending coronary, superior mesenteric, left renal and left external iliac arteries was assessed using electromagnetic flowmeters. Distension of the uterus for periods of 30 min was performed by injecting 20 ml of warm Ringer solution into balloons positioned within the viscus before and after blockade of angiotensin II receptors with losartan. |
2(0,0,0,2) | Details |
| 14576548 | Baranov D, Armstead WM: Selective blockade of AT1 receptor attenuates impairment of hypotensive autoregulation and improves cerebral blood flow after brain injury in the newborn pig. Anesthesiology. 2003 Nov;99(5):1118-24. Two types of angiotensin II receptors, AT1 and AT2, have been identified in the brain. METHODS: Fluid percussion injury was induced in chloralose-anesthetized newborn pigs equipped with closed cranial windows. |
2(0,0,0,2) | Details |
| 17982007 | Girouard H, Lessard A, Capone C, Milner TA, Iadecola C: The neurovascular dysfunction induced by angiotensin II in the mouse neocortex is sexually dimorphic. Am J Physiol Heart Circ Physiol. 2008 Jan;294(1):H156-63. Epub 2007 Nov 2. Cerebral blood flow (CBF) was monitored by laser-Doppler flowmetry in anesthetized (urethane-chloralose) C57BL/6J male and female mice equipped with a cranial window. |
2(0,0,0,2) | Details |
| 14988085 | Stocker SD, Schiltz JC, Sved AF: Acute increases in arterial blood pressure do not reduce plasma levels stimulated by angiotensin II or hyperosmolality in rats. Am J Physiol Regul Integr Comp Physiol. 2004 Jul;287(1):R127-37. Epub 2004 Feb 26. In alpha-chloralose-anesthetized rats infused with hypertonic saline, inflation of an aortic cuff to increase ABP and stimulate arterial baroreceptors did not reduce plasma VP levels. |
0(0,0,0,0) | Details |
| 9061113 | Aneman A, Ponten J, Fandriks L, Eisenhofer G, Friberg P, Biber B: Hemodynamic, sympathetic and angiotensin II responses to PEEP ventilation before and during administration of isoflurane. Acta Anaesthesiol Scand. 1997 Jan;41(1 Pt 1):41-8. METHODS: Renin-angiotensin and sympathetic nervous activity were investigated in mechanically ventilated, normovolemic, chloralose anesthetized pigs before and during administration of 1.4% isoflurane. |
2(0,0,0,2) | Details |
| 7485604 | Stebbins CL, Bonigut S: Spinal angiotensin II influences reflex cardiovascular responses to muscle contraction. Am J Physiol. 1995 Oct;269(4 Pt 2):R864-8. Consequently, in alpha-chloralose-anesthetized cats, contraction-induced increases in mean arterial blood pressure, maximal rate of rise in left ventricular pressure (dP/dt), and heart rate were compared before and after intrathecal injection of the AT1 receptor antagonist losartan (100 or 1,000 micrograms; n = 7). |
2(0,0,0,2) | Details |
| 12860451 | Hocht C, Opezzo JA, Gironacci M, Pena C, Taira CA: Study of the hypothalamic angiotensin system in aortic coarctated rats using the reverse microdialysis technique. Pharmacol Res. 2003 Sep;48(3):301-7. We also studied a possible enhanced pressor response to angiotensin II in aortic coarctated rats in the anterior and posterior hypothalamic area. Wistar urethane-chloralose anaesthetised rats were used. |
2(0,0,0,2) | Details |
| 9331154 | Chen L, Holm M, Fandriks L, Pettersson A, Johansson B: ACE inhibition by enalaprilate stimulates duodenal mucosal alkaline secretion via a bradykinin pathway in the rat. Dig Dis Sci. 1997 Sep;42(9):1908-13. The effects of enalaprilate on duodenal mucosal alkaline secretion (in situ titration) and mean arterial blood pressure were investigated in chloralose-anesthetized male rats. These data suggest that enalaprilate increases duodenal mucosal alkaline secretion via a local bradykinin pathway involving receptors of the bradykinin receptor subtype-2 antagonist, rather than by blockade of endogenous angiotensin II or by central autonomic neural regulation. |
1(0,0,0,1) | Details |
| 15897358 | Gao L, Schultz HD, Patel KP, Zucker IH, Wang W: Augmented input from cardiac sympathetic afferents inhibits baroreflex in rats with heart failure. Hypertension. 2005 Jun;45(6):1173-81. Epub 2005 May 16. Our recent study has indicated that activation of the cardiac sympathetic afferent reflex (CSAR) inhibits the baroreflex in normal rats, and in the rats with CHF the CSAR is significantly enhanced, which is related to augmented central angiotensin II (Ang II) mechanism. To test the hypothesis, the rats with myocardial infarction-induced CHF or sham surgery were anesthetized with alpha-chloralose and urethane, vagotomized, and recordings were made of the mean arterial pressure (MAP) and renal sympathetic nerve activity (RSNA). |
1(0,0,0,1) | Details |
| 12003809 | Zhu GQ, Patel KP, Zucker IH, Wang W: Microinjection of ANG II into paraventricular nucleus enhances cardiac sympathetic afferent reflex in rats. Am J Physiol Heart Circ Physiol. 2002 Jun;282(6):H2039-45. The aims of present study were to determine whether angiotensin II (ANG II) in the paraventricular nucleus (PVN) is involved in the central integration of the cardiac sympathetic afferent reflex and whether this effect is mediated by the ANG type 1 (AT (1)) receptor. While the animals were under alpha-chloralose and urethane anesthesia, mean arterial pressure, heart rate, and renal sympathetic nerve activity (RSNA) were recorded in sinoaortic-denervated and cervical-vagotomized rats. |
1(0,0,0,1) | Details |
| 12111042 | Zhu GQ, Zucker IH, Wang W: Central AT1 receptors are involved in the enhanced cardiac sympathetic afferent reflex in rats with chronic heart failure. Basic Res Cardiol. 2002 Jul;97(4):320-6. The purpose of this study was to determine if the cardiac sympathetic afferent reflex (CSAR) was augmented in rats with coronary ligation-induced chronic heart failure (CHF), and if central angiotensin II (ANG II) was involved in this enhancement. Under alpha-chloralose and urethane anesthesia, mean arterial pressure (MAP), heart rate (HR) and renal sympathetic nerve activity (RSNA) were recorded in sino-aortic denervated and cervical vagotomized rats. |
1(0,0,0,1) | Details |
| 10831530 | Molinari C, Grossini E, Mary DA, Vacca G: Effect of distension of the gallbladder on plasma renin activity in anesthetized pigs. Circulation. 2000 May 30;101(21):2539-45. METHODS AND RESULTS: In 34 alpha-chloralose-anesthetized pigs, balloons positioned within the gallbladder were distended for 30 minutes with volumes of Ringer's solution equal to those of withdrawn bile. In another 15 pigs, blockade of angiotensin II receptors significantly attenuated the pressor and coronary, mesenteric, and iliac vasoconstriction responses to gallbladder distension. |
1(0,0,0,1) | Details |
| 9862392 | Vacca G, Battaglia A, Ferro R, Grossini E, Mary DA, Molinari C, Surico N: The effect of distension of the uterus on plasma renin activity (PRA) in anaesthetized pigs. J Auton Nerv Syst. 1998 Nov 10;73(2-3):163-9. The same methods were used in 14 pigs which were anaesthetized with alpha-chloralose and artificially ventilated. Changes in plasma renin activity (PRA) were assessed during the last minute of distension by radioimmunoassay of angiotensin I. |
1(0,0,0,1) | Details |
| 11087253 | Ito S, Sved AF: Pharmacological profile of depressor response elicited by sarthran in rat ventrolateral medulla. Am J Physiol Heart Circ Physiol. 2000 Dec;279(6):H2961-6. Injection of sarthran, an angiotensin receptor antagonist, bilaterally into the rostral ventrolateral medulla (RVLM) of alpha-chloralose-anesthetized rats decreases arterial pressure (AP) to the same extent as total autonomic blockade. Coinjection of angiotensin II (ANG II) prevented the sarthran-evoked decrease in AP, but this action of ANG II was markedly attenuated by pretreatment of the RVLM with the aminopeptidase inhibitor amastatin. |
1(0,0,0,1) | Details |
| 15475555 | Zhu GQ, Gao L, Patel KP, Zucker IH, Wang W: ANG II in the paraventricular nucleus potentiates the cardiac sympathetic afferent reflex in rats with heart failure. J Appl Physiol. 2004 Nov;97(5):1746-54. In addition, central angiotensin II (ANG II) is an important modulator of this reflex. Under alpha-chloralose and urethane anesthesia, renal sympathetic nerve activity (RSNA) was recorded. |
1(0,0,0,1) | Details |
| 19770402 | Arnold AC, Shaltout HA, Gallagher PE, Diz DI: Leptin impairs cardiovagal baroreflex function at the level of the solitary tract nucleus. Hypertension. 2009 Nov;54(5):1001-8. Epub 2009 Sep 21. Although solitary tract nucleus microinjection of 144 fmol/60 nL of leptin had no significant effect on baroreflex sensitivity for control of the heart rate in urethane/chloralose-anesthetized Sprague-Dawley rats, 500 fmol of leptin impaired baroreflex sensitivity for bradycardia in response to increases in pressure (1.15+/-0.04 versus 0.52+/-0.12 ms/mm Hg; P <0.01). Transgenic ASrAOGEN rats with low brain angiotensinogen have an upregulation of the leptin receptor and p85 alpha mRNA in the dorsal medulla relative to Sprague-Dawley rats. |
1(0,0,0,1) | Details |
| 7762836 | Murr R, Berger S, Schurer L, Peter K, Baethmann A: Influence of isoflurane, thiopental, and alpha-chloralose on formation of brain edema resulting from a focal cryogenic lesion. Anesth Analg. 1995 Jun;80(6):1108-15. Animals anesthetized with isoflurane required support of arterial pressure by angiotensin II (0.15 micrograms.kg-1.min-1). |
1(0,0,0,1) | Details |
| 1905489 | Hirooka Y, Ando S, Imaizumi T, Suzuki S, Takeshita A: Exogenous does not sensitize arterial baroreceptors. Am J Physiol. 1991 Jun;260(6 Pt 2):H1760-6. Finally, we examined changes in AoP, ANA, and AoD during ramp increases or decreases of AoP caused by intravenous angiotensin II or NG under background infusion of saline, or SNP (n = 6). In rabbits anesthetized with alpha-chloralose (n = 12), we examined reflex changes in multiunit efferent renal sympathetic nerve activity (RSNA) during hypotension caused by intravenous (0.1, 0.2, 0.5, 1.0, 2.0 micrograms/kg), nitroglycerin (NG; 5, 10, 20, 50, 100 micrograms/kg), and sodium nitroprusside (SNP; 5, 10, 20, 50, 100 micrograms/kg) before and after bilateral vagotomy. |
1(0,0,0,1) | Details |
| 8213199 | Morita-Tsuzuki Y, Bouskela E, Hardebo JE: Effects of synthesis blockade and angiotensin II on blood flow and spontaneous vasomotion in the rat cerebral microcirculation. Acta Physiol Scand. 1993 Aug;148(4):449-54. Experiments were performed on Sprague-Dawley rats anaesthetized with alpha-chloralose. |
1(0,0,0,1) | Details |
| 15243307 | Gautier P, Guillemare E, Djandjighian L, Marion A, Planchenault J, Bernhart C, Herbert JM, Nisato D: In vivo and in vitro characterization of the novel antiarrhythmic agent SSR149744C: electrophysiological, anti-adrenergic, and anti-angiotensin II effects. J Cardiovasc Pharmacol. 2004 Aug;44(2):244-57. In chloralose-anesthetized dogs, SSR149744C (1-10 mg/kg i.v.) prolonged the sinus cycle length, A-H interval, Wenckebach cycle length, atrial effective refractory period (ERP), and atrio-ventricular node ERP in a dose-dependent manner without change of ventricular ERP and HV, QRS, or QTc intervals. |
1(0,0,0,1) | Details |
| 7969934 | Murase S, Inui K, Nosaka S: Baroreceptor inhibition of the locus coeruleus noradrenergic neurons. . Neuroscience. 1994 Aug;61(3):635-43. In chloralose- and urethane-anesthetized rats, the central cut end of the aortic depressor nerve, which does not contain chemoreceptor afferents in this species, was stimulated electrically to excite baroreceptor afferents after bilateral vagotomy and sectioning of the carotid sinus nerve. When blood pressure was elevated by an intravenous injection of a pressor agent, methoxamine or angiotensin II, or by rapid blood loading, ongoing activities of all locus coeruleus neurons tested were suppressed. |
1(0,0,0,1) | Details |
| 12719760 | Molinari C, Battaglia A, Grossini E, Florio S, Mary DA, Vassanelli C, Vacca G: Activation of the renin-angiotensin system contributes to the peripheral vasoconstriction reflexly caused by stomach distension in anaesthetized pigs. Exp Physiol. 2003 May;88(3):359-67. In pigs anaesthetized with alpha-chloralose, changes in anterior descending coronary, superior mesenteric and left external iliac blood flow caused by stomach distension before and after blockade of angiotensin II receptors with losartan were assessed using electromagnetic flowmeters. |
83(1,1,1,3) | Details |
| 10517817 | Moosavi SM, Johns EJ: Effect of renal perfusion pressure on renal function, renin release and renin and angiotensinogen gene expression in rats. J Physiol. 1999 Oct 1;520 Pt 1:261-9. Chloralose-urethane anaesthesia and surgery caused a rise in plasma renin activity but was associated with a suppression of renal renin (50 %, P < 0.01) and angiotensinogen (40 %, P < 0.05) gene expression. |
83(1,1,1,3) | Details |
| 12623990 | Ito S, Hiratsuka M, Komatsu K, Tsukamoto K, Kanmatsuse K, Sved AF: Ventrolateral medulla AT1 receptors support arterial pressure in Dahl salt-sensitive rats. Hypertension. 2003 Mar;41(3 Pt 2):744-50. Epub 2003 Jan 20. Rats were anesthetized with alpha-chloralose, and the effects of microinjecting the AT1R antagonist valsartan (Val) or angiotensin II (Ang II) into the RVLM on MAP were measured. |
82(1,1,1,2) | Details |
| 9361350 | Aneman A, Pettersson A, Eisenhofer G, Friberg P, Holm M, von Bothmer C, Fandriks L: Sympathetic and renin-angiotensin activation during graded hypovolemia in pigs: impact on mesenteric perfusion and duodenal mucosal function. Shock. 1997 Nov;8(5):378-84. Chloralose-anesthetized pigs subjected to 20 and 40% blood volume reductions were randomized to controls or administered guanethidine or enalaprilate to block sympathetic and angiotensinergic activation, as assessed by plasma spillover and angiotensin II levels, respectively. |
81(1,1,1,1) | Details |
| 11358943 | Diz DI, Westwood B, Averill DB: AT (1) antisense distinguishes receptors mediating angiotensin II actions in solitary tract nucleus. Hypertension. 2001 May;37(5):1292-7. Ang II injections (250 fmol/30 nL) into the nTS reduced blood pressure by 14+/-1 mm Hg and heart rate by 13+/-1 bpm (n=8) in male Sprague-Dawley rats anesthetized with chloralose/urethane. |
37(0,1,1,7) | Details |
| 18347230 | Arnold AC, Sakima A, Ganten D, Ferrario CM, Diz DI: Modulation of reflex function by endogenous angiotensins in older transgenic rats with low glial angiotensinogen. Hypertension. 2008 May;51(5):1326-31. Epub 2008 Mar 17. Baroreflex sensitivity for control of heart rate and chemosensitive vagal afferent activation in response to phenylbiguanide were measured before and after bilateral microinjection of the angiotensin II type 1 receptor antagonist candesartan and angiotensin-(1-7) receptor antagonist (D- (7))-angiotensin-(1-7) in urethane/chloralose-anesthetized rats. |
34(0,1,1,4) | Details |