| Name | PPAR gamma |
|---|---|
| Synonyms | HUMPPARG; PAX8/PPARG fusion gene; NR1C3; PPAR gamma; PPAR gamma2; PPARG; PPARG 1; PPARG 2… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19464576 | Liu DS, Liu WJ, Chen L, Ou XM, Wang T, Feng YL, Zhang SF, Xu D, Chen YJ, Wen FQ: a peroxisome proliferator-activated receptor-gamma agonist, attenuates acrolein-induced airway mucus hypersecretion in rats. Toxicology. 2009 Jun 16;260(1-3):112-9. Epub 2009 Apr 5. |
193(2,3,3,3) | Details |
| 19576043 | Liu WJ, Li WC, Xu ZB, Feng YL: [Effect of peroxisome proliferators activated receptor gamma and its ligand on airway mucus hypersecretion in rats]. Zhonghua Jie He He Hu Xi Za Zhi. 2009 Apr;32(4):282-6. PPAR-gamma and its ligand inhibited acrolein-induced airway mucus hypersecretion, possibly through downregulation of MUC5AC. |
107(1,1,5,7) | Details |
| 17658243 | Olmos G, Conde I, Arenas I, Del Peso L, Castellanos C, Landazuri MO, Lucio-Cazana J: Accumulation of hypoxia-inducible factor-1alpha through a novel electrophilic, thiol antioxidant-sensitive mechanism. Cell Signal. 2007 Oct;19(10):2098-105. Epub 2007 Jun 21. 15-deoxy-Delta (12,14)-prostaglandin-J (2) (15d-PGJ (2)) is a peroxisome-activated proliferator receptor-gamma (PPARgamma) agonist which contains an alpha,beta-unsaturated electrophilic ketone involved in nucleophilic addition reactions to thiols. Finally, HIF-1alpha expression was increased by the electrophilic alpha,beta-unsaturated compounds acrolein and PGA (2), but not by 9,10-dihydro-15d-PGJ (2), which lacks the electrophilic cyclopentenone moiety. |
1(0,0,0,1) | Details |
| 14657518 | Maddox JF, Domzalski AC, Roth RA, Ganey PE: 15-deoxy enhances allyl -induced toxicity in rat hepatocytes. Toxicol Sci. 2004 Feb;77(2):290-8. Epub 2003 Dec 2. In a concentration-dependent manner, 15d-PGJ (2) significantly augmented cell death caused by allyl in isolated rat hepatocytes. 15d-PGJ (2) also increased the cytotoxicity of acrolein, the active metabolite of allyl |
0(0,0,0,0) | Details |