Protein Information

Name nociceptin receptor
Synonyms KOR 3; KOR3; Kappa type 3 opioid receptor; NOCIR; Nociceptin receptor; OOR; OPRL 1; OPRL1…

Compound Information

Name chloralose
CAS

Reference List

PubMed Abstract RScore(About this table)
15707012 Maslov LN, Krylatov AV, Lishmanov IuB, Galo G, Ma K, Stakheev DL: [The mechanism of antiarrhythmic action of the endogenous ORL1 receptor agonist nociceptin]. Eksp Klin Farmakol. 2004 Nov-Dec;67(6):32-5.

Prophylactic intravenous (i.v.) injections of a selective agonist of ORL1 receptors nociceptin (orphanin FQ) in a dose of 0.4 mg/kg prevented the development of aconitine-induced arrhythmia in rats narcotized with diethyl ether or chloralose.
82(1,1,1,2) Details
10350539 Chu X, Xu N, Li P, Mao L, Wang JQ: Inhibition of cardiovascular activity following microinjection of novel opioid-like neuropeptide nociceptin (orphanin FQ) into the rat rostral ventrolateral medulla. Brain Res. 1999 May 22;829(1-2):134-42.

Nociceptin (orphanin FQ), the newly discovered endogenous ligand for the novel opioid receptor-like 1 receptor, has been initially found to participate in pain modulation.
In this study, centrally mediated cardiovascular actions of this peptide were investigated in the alpha-chloralose/urethane-anesthetized rats.
3(0,0,0,3) Details
15649868 Crisostomo MM, Li P, Tjen-A-Looi SC, Longhurst JC: Nociceptin in rVLM mediates electroacupuncture inhibition of cardiovascular reflex excitatory response in rats. J Appl Physiol. 2005 Jun;98(6):2056-63. Epub 2005 Jan 13.

Blood pressure in ventilated male Sprague-Dawley rats (400-600 g) anesthetized by ketamine and alpha-chloralose was measured during balloon inflation of the stomach.
In contrast, microinjection of a nociceptin receptor antagonist into the rVLM promptly reversed the EA response.
3(0,0,0,3) Details