Protein Information

Name PACAP
Synonyms Caspase 2 binding protein; PACAP; HSPC190; PACAP protein; Proapoptotic caspase adaptor protein; PACAP proteins; Proapoptotic caspase adaptor proteins

Compound Information

Name chloralose
CAS

Reference List

PubMed Abstract RScore(About this table)
9369314 Armstead WM: Role of impaired cAMP and calcium-sensitive K+ channel function in altered cerebral hemodynamics following brain injury. Brain Res. 1997 Sep 12;768(1-2):177-84.

Chloralose-anesthetized piglets equipped with a closed cranial window were connected to a percussion device consisting of a saline-filled cylindrical reservoir and a metal pendulum.
Similarly, FPI attenuated dilation to pituitary adenylate cyclase activating peptide (PACAP), an endogenous activator of adenylate cyclase, and NS 1619, a K (Ca2+) channel agonist (9 +/- 1 and 16 +/- 1 vs. 3 +/- 1 and 5 +/- 1% for NS 1619 10 (-8), 10 (-6) M before and after FPI, respectively, n = 8).
2(0,0,0,2) Details
8436621 Uddman R, Goadsby PJ, Jansen I, Edvinsson L: PACAP, a VIP-like peptide: immunohistochemical localization and effect upon cat pial arteries and cerebral blood flow. J Cereb Blood Flow Metab. 1993 Mar;13(2):291-7.

In cats anesthetized with alpha-chloralose, intracerebral microinjection of PACAP effected a moderate increase in cerebral blood flow.
13(0,0,1,8) Details
9176233 Krowicki ZK, Arimura A, Nathan NA, Hornby PJ: Hindbrain effects of PACAP on gastric motor function in the rat. Am J Physiol. 1997 May;272(5 Pt 1):G1221-9.

Therefore, multiple-barreled micropipettes were used to inject PACAP-38 (1-100 pmol) into each of these nuclei in alpha-chloralose anesthetized rats, while intragastric pressure, pyloric and greater curvature smooth muscle contractile activity, blood pressure, and heart rate were recorded.
12(0,0,1,7) Details