| Name | transferase |
|---|---|
| Synonyms | 4' phosphopantetheinyl transferase; 4' phosphopantetheinyl transferase; AASD PPT; AASDHPPT; AASDPPT; Alpha aminoadipic semialdehyde dehydrogenase phosphopantetheinyl transferase; Aminoadipate semialdehyde dehydrogenase phosphopantetheinyl transferase; CGI 80… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18540993 | Khan M, Singh J, Singh I: Plasmalogen deficiency in cerebral adrenoleukodystrophy and its modulation by lovastatin. J Neurochem. 2008 Aug;106(4):1766-79. Epub 2008 Jun 7. The reduction in PlsEtn was related to oxidative stress, as supported by increased levels of reactive lipid aldehydes and acrolein) and deleterious oxidized proteins (protein carbonyl) in all areas of the cALD brain. This inverse relationship between the levels of PlsEtn and reactive species (ROS) was further supported in an in vitro study using gene-silencing for -acyl transferase, a key enzyme for PlsEtn biosynthesis. |
1(0,0,0,1) | Details |
| 2304453 | Berhane K, Mannervik B: Inactivation of the genotoxic acrolein by human glutathione transferases of classes alpha, mu, and pi. Mol Pharmacol. 1990 Feb;37(2):251-4. As measured by the kcat/Km value, acrolein ranks among the most active substrates known for transferase pi. |
88(1,1,2,3) | Details |
| 2017737 | Scott TR, Kirsch RE: Glutathione S-transferases YcYfetus and YcYc--kinetic and inhibitor studies relating to their peroxidase activities. S Afr Med J. 1991 Mar 16;79(6):298-301. Depending on the ligand, the inhibition profiles of these two iso-enzymes when measured with either the peroxidase substrate, cumene hydroperoxide or the standard GSH S-transferase substrate 1-chloro-2,4-dinitrobenzene were found to be either very similar (sulphobromophthalein) or markedly different (rose Bengal and acrolein). |
31(0,1,1,1) | Details |
| 3377801 | Haenen GR, Vermeulen NP, Tai Tin Tsoi JN, Ragetli HM, Timmerman H, Blast A: Activation of the microsomal glutathione-S-transferase and reduction of the dependent protection against lipid peroxidation by acrolein. Biochem Pharmacol. 1988 May 15;37(10):1933-8. The effect of acrolein in vitro and in vivo on the (GSH) dependent protection of liver microsomes against lipid peroxidation, and on the microsomal GSH-S-transferase (GSH-tr) in the rat was determined. |
6(0,0,1,1) | Details |
| 15019089 | Gardner R, Kazi S, Ellis EM: Detoxication of the environmental pollutant acrolein by a rat liver aldo-keto reductase. Toxicol Lett. 2004 Mar 14;148(1-2):65-72. Cells expressing AKR7A1 were also found to be less susceptible to DNA damage, showing a decrease in mutation rate in the presence of acrolein as measured by phosphoribosyl transferase (HGPRT) mutagenicity assays. |
6(0,0,1,1) | Details |
| 17485251 | Hansen RJ, Ludeman SM, Paikoff SJ, Pegg AE, Dolan ME: Role of MGMT in protecting against cyclophosphamide-induced toxicity in cells and animals. DNA Repair. 2007 Aug 1;6(8):1145-54. Epub 2007 May 7. CHO cells expressing a mutant form of MGMT (MGMT (R128A)), known to have > 1000-fold less repair activity towards alkylated DNA while maintaining full active site transferase activity towards low molecular weight substrates, exhibited equivalent CAA- and acrolein-induced cytotoxicity to that of CHO cells transfected with plasmid control. |
31(0,1,1,1) | Details |
| 12535742 | Cao Z, Hardej D, Trombetta LD, Trush MA, Li Y: Induction of cellular and glutathione S-transferase by 3H-1,2-dithiole-3-thione in rat aortic smooth muscle A10 cells: protection against acrolein-induced toxicity. Atherosclerosis. 2003 Feb;166(2):291-301. Because (GSH) and GSH S-transferase (GST) are a major cellular defense against the toxic effects of reactive aldehydes, in this study we have characterized the inducibility of GSH and GST by the unique chemoprotective agent, 3H-1,2-dithiole-3-thione (D3T) and their protective effects against acrolein-induced toxicity in rat aortic smooth muscle A10 cells. |
6(0,0,1,1) | Details |
| 11244358 | Park JY, Kwon BM, Chung SK, Kim JH, Joo CK: Inhibitory effect of 2'-O-benzoylcinnamaldehyde on vascular endothelial cell proliferation and migration. Ophthalmic Res. 2001 Mar-Apr;33(2):111-6. PURPOSE: To evaluate the inhibitory effect of the farnesyl transferase inhibitor 2'-O-benzoylcinnamaldehyde (CB 2'-ph) on proliferation and migration of vascular endothelial cells. |
2(0,0,0,2) | Details |
| 15554254 | Sung ND, Cho YK, Kwon BM, Hyun KH, Kim CK: 3D QSAR studies on analogues as farnesyl protein transferase inhibitors. Arch Pharm Res. 2004 Oct;27(10):1001-8. |
2(0,0,0,2) | Details |
| 18028974 | Higgins LG, Cavin C, Itoh K, Yamamoto M, Hayes JD: Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Toxicol Appl Pharmacol. 2008 Feb 1;226(3):328-37. Epub 2007 Sep 26. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein.. Mice fed 6% coffee also had increased amounts of mRNA for UDP-glucuronosyl transferase 1A6 (UGT1A6) and the glutamate cysteine ligase catalytic (GCLC) subunit of between 3- and 10-fold in the small intestine. |
1(0,0,0,1) | Details |
| 16458197 | Cingolani C, Rogers B, Lu L, Kachi S, Shen J, Campochiaro PA: Retinal degeneration from oxidative damage. Free Radic Biol Med. 2006 Feb 15;40(4):660-9. Epub 2005 Oct 21. Histology in paraquat-injected eyes showed condensation of chromatin and thinning of the inner and outer nuclear layers indicating cell death, and terminal deoxynucleotidyl transferase-mediated duTP-biotinide end labeling demonstrated that one mechanism of cell death was apoptosis. Fluorescence in the retina and retinal pigmented epithelium after intraocular injection of paraquat followed by perfusion with hydroethidine indicated high levels of radicals, and oxidative damage was demonstrated by staining for acrolein and enzyme-linked immunosorbent assay for carbonyl adducts. |
1(0,0,0,1) | Details |
| 12694875 | Jeong HW, Han DC, Son KH, Han MY, Lim JS, Ha JH, Lee CW, Kim HM, Kim HC, Kwon BM: Antitumor effect of the derivative CB403 through the arrest of cell cycle progression in the G2/M phase. Biochem Pharmacol. 2003 Apr 15;65(8):1343-50. Cinnamaldehydes have been shown to have inhibitory effects on farnesyl protein transferase (FPTase; EC 2.5.1.29) in vitro, angiogenesis, cell-cell adhesion, and tumor cell growth and to be immunomodulators. |
1(0,0,0,1) | Details |
| 16405947 | Moon EY, Lee MR, Wang AG, Lee JH, Kim HC, Kim HM, Kim JM, Kwon BM, Yu DY: Delayed occurrence of H-ras12V-induced hepatocellular carcinoma with long-term treatment with cinnamaldehydes. Eur J Pharmacol. 2006 Jan 20;530(3):270-5. from the bark of Cinnamomum cassia has been reported to have antitumor activity mediated by the inhibition of farnesyl transferase. |
1(0,0,0,1) | Details |
| 14660655 | Han DC, Lee MY, Shin KD, Jeon SB, Kim JM, Son KH, Kim HC, Kim HM, Kwon BM: 2'-benzoyloxycinnamaldehyde induces apoptosis in human carcinoma via reactive species. J Biol Chem. 2004 Feb 20;279(8):6911-20. Epub 2003 Dec 3. 2'-hydroxycinnamaldehyde (HCA) has been shown to have inhibitory effects on farnesyl protein transferase in vitro, angiogenesis, and tumor cell growth. |
1(0,0,0,1) | Details |
| 11723234 | Schwartz PS, Waxman DJ: Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells. . Mol Pharmacol. 2001 Dec;60(6):1268-79. Cyclophosphamide (CPA), a widely used oxazaphosphorine anti-cancer prodrug, is inactive until it is metabolized by cytochrome P450 to yield phosphoramide mustard and acrolein, which alkylate DNA and proteins, respectively. Conversely, overexpression of the mitochondrial antiapoptotic factor Bcl-2 blocked caspase 9 activation, leading to an inhibition of drug-induced plasma membrane permeability and blebbing, terminal deoxynucleotidyl transferase nick-end labeling positivity, PARP cleavage, Annexin V positivity, and drug-induced cell death. |
1(0,0,0,1) | Details |
| 16343908 | Shin DS, Kim JH, Lee SK, Han DC, Son KH, Kim HM, Cheon HG, Kim KR, Sung ND, Lee SJ, Kang SK, Kwon BM: Synthesis and biological evaluation of dimeric cinnamaldehydes as potent antitumor agents. Bioorg Med Chem. 2006 Apr 15;14(8):2498-506. Epub 2005 Dec 15. It has been reported that 2-hydroxycinnamaldehyde and 2-benzoyl-oxycinnamaldehyde inhibited the activity of farnesyl protein transferase, angiogenesis, cell-cell adhesion, and tumor growth in vivo model. |
1(0,0,0,1) | Details |
| 18514610 | Parikh JG, Saraswathy S, Rao NA: Photoreceptor oxidative damage in sympathetic ophthalmia. . Am J Ophthalmol. 2008 Dec;146(6):866-75.e2. Epub 2008 Jun 2. Deparaffinized sections of the globes were processed to localize tumor necrosis factor-alpha (TNF-alpha), tumor necrosis factor receptor-1 (TNF-R1), acrolein, inducible synthase (iNOS), and nitrotyrosine by immunolocalization method. Apoptotic cells were detected by Terminal deoxynucleotidyl transferase - Nick End Labeling (TUNEL) assay and were localized to the site of oxidative stress using antinitrotyrosine antibody. |
1(0,0,0,1) | Details |