Protein Information

Name alpha 1 adrenergic receptor
Synonyms ADRA 1; ADRA1; ADRA1B; ALPHA1BAR; Alpha 1 adrenergic receptor; Alpha 1B adrenergic receptor; Alpha 1B adrenoceptor; Alpha 1B adrenoreceptor…

Compound Information

Name chloralose
CAS

Reference List

PubMed Abstract RScore(About this table)
7869533 Danuser H, Thor KB: Inhibition of central sympathetic and somatic outflow to the lower urinary tract of the cat by the alpha 1 adrenergic receptor antagonist prazosin. J Urol. 1995 Apr;153(4):1308-12.

The present experiments examined the effects of the selective alpha 1 adrenergic receptor antagonist prazosin on sympathetic activity recorded from the hypogastric nerve in chloralose-anesthetized cats.
36(0,1,1,6) Details
12183010 Tsukamoto K, Ito S, Katsunuma N, Hiratsuka M, Masubuchi Y, Kanai T, Kawabe T, Yajima Y, Kanmatsuse K: Effect of phenylephrine injected into the nucleus tractus solitarius of Sprague-Dawley rats and spontaneously hypertensive rats. Brain Res Bull. 2002 Aug 15;58(4):351-6.

In alpha-chloralose-anesthetized Sprague-Dawley (SD) rats with unilateral nucleus tractus solitarius (NTS) lesions, injection of the alpha (1)-adrenergic receptor agonist phenylephrine into the contralateral NTS dose-dependently increased arterial pressure (AP).
33(0,1,1,3) Details
7636745 Danuser H, Bemis K, Thor KB: Pharmacological analysis of the noradrenergic control of central sympathetic and somatic reflexes controlling the lower urinary tract in the anesthetized cat. J Pharmacol Exp Ther. 1995 Aug;274(2):820-5.

In the present study, we pharmacologically analyzed the role of noradrenergic systems on the sympathetic and somatic pathways to the lower urinary tract and asked: 1) Are alpha-1, alpha-2, or beta-adrenergic receptors tonically active along sympathetic and/or somatic reflex pathways? And 2) what is the net effect of increasing the extracellular levels of NE by administration of a NE reuptake inhibitor? To address these questions, we recorded evoked potentials from the central ends of the hypogastric and pudendal nerves in response to electrical stimulation of the pelvic and pudendal nerves in chloralose-anesthetized cats, and the effects of prazosin (1-300 micrograms/kg i.v.), an alpha-1-adrenergic receptor antagonist; idazoxan (1-300 micrograms/kg i.v.), an alpha-2-adrenergic receptor antagonist; propranolol (1 mg/kg i.v.), a beta-adrenergic receptor antagonist; and tomoxetine (0.003-3 mg/kg i.v.), a selective NE reuptake inhibitor, were examined.
31(0,1,1,1) Details
1661441 Zheng JA, Pan JY, Hou HC: [Role of paraventricular nucleus of hypothalamus in pressor response to stimulation of renal afferent nerve in cats]. Sheng Li Xue Bao. 1991 Aug;43(4):330-7.

The purpose of this study is to investigate the role of paraventricular nucleus of the hypothalamus (PVN) and alpha 1 adrenergic receptor of PVN in the pressor responses to stimulation of renal afferent nerve in alpha 1-chloralose-anesthetized cats with carotid sinoaortic denervation and vagotomy.
7(0,0,1,2) Details
17196224 Conde CM, Cyrino FZ, Bottino DA, Gardette J, Bouskela E: Longchain n-3 polyunsaturated fatty acids and microvascular reactivity: observation in the hamster cheek pouch. Microvasc Res. 2007 May;73(3):237-47. Epub 2006 Dec 28.


Anesthesia was induced by sodium pentobarbital (i.p.) and maintained with alpha-chloralose through the femoral vein.
0(0,0,0,0) Details
7636716 Thor KB, Katofiasc MA: Effects of duloxetine, a combined serotonin and norepinephrine reuptake inhibitor, on central neural control of lower urinary tract function in the chloralose-anesthetized female cat. J Pharmacol Exp Ther. 1995 Aug;274(2):1014-24.

0(0,0,0,0) Details