Protein Information

Name IL 6
Synonyms 26 kd protein; B cell differentiation factor; B cell stimulatory factor 2; BSF 2; BSF2; CDF; CTL differentiation factor; HGF…

Compound Information

Name acrolein
CAS 2-propenal

Reference List

PubMed Abstract RScore(About this table)
18757054 Yoshida M, Tomitori H, Machi Y, Katagiri D, Ueda S, Horiguchi K, Kobayashi E, Saeki N, Nishimura K, Ishii I, Kashiwagi K, Igarashi K: Acrolein, IL-6 and CRP as markers of silent brain infarction. . Atherosclerosis. 2009 Apr;203(2):557-62. Epub 2008 Jul 26.

It was found that the levels of protein-conjugated acrolein (PC-Acro), interleukin-6 (IL-6) and C-reactive protein (CRP) were significantly higher in SBI than in normal subjects.
39(0,1,2,4) Details
16860297 Doyle M, Sexton KG, Jeffries H, Jaspers I: Atmospheric photochemical transformations enhance 1,3-butadiene-induced inflammatory responses in human epithelial cells: The role of ozone and other photochemical degradation products. Chem Biol Interact. 2007 Mar 20;166(1-3):163-9. Epub 2006 Jun 3.

Exposure to the photochemically generated products of BD (primarily acrolein, acetaldehyde, formaldehyde, furan and ozone) induced significant increases in cytotoxicity, IL-8, and IL-6 gene expression compared to a synthetic mixture of primary products that was created by injecting the correct concentrations of the detected products from the irradiation experiments.
31(0,1,1,1) Details
16413037 Wung BS, Wu CC, Hsu MC, Hsieh CW: 15-Deoxy-Delta (12,14)-prostaglandin J (2) suppresses IL-6-induced STAT3 phosphorylation via electrophilic reactivity in endothelial cells. Life Sci. 2006 May 22;78(26):3035-42. Epub 2006 Jan 18.

The electrophilic compound, acrolein, mimics the inhibition effect of 15d-PGJ (2).
3(0,0,0,3) Details
11948286 Malley SE, Vizzard MA: Changes in urinary bladder cytokine mRNA and protein after cyclophosphamide-induced cystitis. Physiol Genomics. 2002;9(1):5-13.


An RNase protection assay was used to measure changes in rat bladder cytokine mRNA [interferon-gamma (IFN)-gamma, interleukin-1alpha/beta (IL-1alpha/beta), IL-2, IL-3, IL-4, IL-5, IL-6, IL-10, and tumor necrosis factor-alpha/beta (TNF-alpha/beta)] after acute (4 h), intermediate (48 h), or chronic (10 day) cystitis.
2(0,0,0,2) Details
18602273 Rummenie VT, Matsumoto Y, Dogru M, Wang Y, Hu Y, Ward SK, Igarashi A, Wakamatsu T, Ibrahim O, Goto E, Luyten G, Inoue H, Saito I, Shimazaki J, Tsubota K: Tear cytokine and ocular surface alterations following brief passive cigarette smoke exposure. Cytokine. 2008 Aug;43(2):200-8. Epub 2008 Jul 3.

Tear samples were obtained before, 5 min and 24 h after smoke exposure to detect tear hexanoyl-lysine (HEL), acrolein and inflammatory cytokine concentrations.
Tear HEL and IL-6 concentrations increased significantly 24 h after smoke exposure.
1(0,0,0,1) Details
19605955 Bryniarski K, Szczepanik M, Ptak M, Zemelka M, Ptak W: Influence of cyclophosphamide and its metabolic products on the activity of peritoneal macrophages in mice. Pharmacol Rep. 2009 May-Jun;61(3):550-7.


Our experiments show that treatment of Mf with ACR or NM stimulates the in vitro production of pro-inflammatory IL-6 and IL-12 and down-regulates anti-inflammatory IL-10 and TGF-beta cytokines.
1(0,0,0,1) Details
18951912 Haberzettl P, Vladykovskaya E, Srivastava S, Bhatnagar A: Role of endoplasmic reticulum stress in acrolein-induced endothelial activation. Toxicol Appl Pharmacol. 2009 Jan 1;234(1):14-24. Epub 2008 Oct 7.

0(0,0,0,0) Details