| Name | cyclooxygenase 2 |
|---|---|
| Synonyms | COX 2; COX2; PHS2; PGG/HS; Cyclooxygenase 2; Cyclooxygenase 2b; Cycloxygenase 2; PGH synthase 2… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12444669 | Huss U, Ringbom T, Perera P, Bohlin L, Vasange M: Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay. J Nat Prod. 2002 Nov;65(11):1517-21. A rapid semi-homogeneous cyclooxygenase-2 (COX-2) enzymatic assay using scintillation proximity assay (SPA) technology was developed, and 49 ubiquitous plant secondary metabolites were screened for inhibition of COX-2-catalyzed (2) (PGE (2)) biosynthesis. |
1(0,0,0,1) | Details |
| 17318410 | Sarkar P, Hayes BE: Induction of COX-2 by acrolein in rat lung epithelial cells. . Mol Cell Biochem. 2007 Jul;301(1-2):191-9. Epub 2007 Feb 21. Chronic inflammation, associated with expression of cyclooxygenase-2 (COX-2) and prostaglandins, are predisposing factors for malignancy. |
1(0,0,0,1) | Details |
| 18234483 | Macedo FY, Baltazar F, Mourao LC, Almeida PR, Mota JM, Schmitt FC, Ribeiro RA: Induction of COX-2 expression by acrolein in the rat model of hemorrhagic cystitis. Exp Toxicol Pathol. 2008 Apr;59(6):425-30. Epub 2008 Jan 29. In this study, we investigate the participation of cyclooxygenase-2 (COX-2) on ACR-induced HC. |
1(0,0,0,1) | Details |
| 14657518 | Maddox JF, Domzalski AC, Roth RA, Ganey PE: 15-deoxy enhances allyl -induced toxicity in rat hepatocytes. Toxicol Sci. 2004 Feb;77(2):290-8. Epub 2003 Dec 2. Allyl causes hepatotoxicity that is potentiated by small doses of bacterial lipopolysaccharide (LPS) through a cyclooxygenase-2 (COX-2)-dependent mechanism. In a concentration-dependent manner, 15d-PGJ (2) significantly augmented cell death caused by allyl in isolated rat hepatocytes. 15d-PGJ (2) also increased the cytotoxicity of acrolein, the active metabolite of allyl |
1(0,0,0,1) | Details |
| 16624280 | Guo JY, Huo HR, Zhao BS, Liu HB, Li LF, Ma YY, Guo SY, Jiang TL: reduces IL-1beta-induced cyclooxygenase-2 activity in rat cerebral microvascular endothelial cells. Eur J Pharmacol. 2006 May 10;537(1-3):174-80. Epub 2006 Mar 10. |
1(0,0,0,1) | Details |
| 18445509 | Wang ZY, Wang P, Merriam FV, Bjorling DE: Lack of TRPV1 inhibits cystitis-induced increased mechanical sensitivity in mice. Pain. 2008 Sep 30;139(1):158-67. Epub 2008 Apr 28. We investigated participation of TRPV1 in visceral pain associated with bladder inflammation induced in mice by systemic treatment with cyclophosphamide or intravesical instillation of acrolein. |
0(0,0,0,0) | Details |
| 18448814 | Park YS, Taniguchi N: Acrolein induces inflammatory response underlying endothelial dysfunction: a risk factor for atherosclerosis. Ann N Y Acad Sci. 2008 Apr;1126:185-9. Our study demonstrates that acrolein, a known toxin in tobacco smoke, elevates oxidative stress via inactivation of thioredoxin reductase and stimulates expression of cyclooxygenase-2 through activation of the protein kinase C, p38 mitogen-activated protein kinase, and cAMP response element-binding protein pathway in endothelial cells. |
81(1,1,1,1) | Details |
| 17363696 | Park YS, Kim J, Misonou Y, Takamiya R, Takahashi M, Freeman MR, Taniguchi N: Acrolein induces cyclooxygenase-2 and prostaglandin production in human umbilical vein endothelial cells: roles of p38 MAP kinase. Arterioscler Thromb Vasc Biol. 2007 Jun;27(6):1319-25. Epub 2007 Mar 15. |
74(0,2,4,4) | Details |
| 11525870 | Blair IA: Lipid hydroperoxide-mediated DNA damage. Exp Gerontol. 2001 Sep;36(9):1473-81. It can also up-regulate cyclooxygenase-2 expression. Malondialdehyde (beta-hydroxy-acrolein), another genotoxic bifunctional electrophile, is formed during homolytic decomposition of lipid hydroperoxides that contain more than two double bonds. |
2(0,0,0,2) | Details |