| Name | ALDH 1 |
|---|---|
| Synonyms | ALDC; ALDH 1; ALDH E1; ALDH1; ALDH11; ALDH1A1; ALHDII; Acetaldehyde dehydrogenase 1… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9884322 | Ren S, Kalhorn TF, Slattery JT: Inhibition of human aldehyde dehydrogenase 1 by the 4-hydroxycyclophosphamide degradation product acrolein. Drug Metab Dispos. 1999 Jan;27(1):133-7. |
247(3,3,3,7) | Details |
| 11741210 | Ren S, Slatterly JT: Inhibition of carboxyethylphosphoramide mustard formation from 4-hydroxycyclophosphamide by carmustine. AAPS PharmSci. 1999;1(3):E14. The calculated %inhibition of ALDH1 activity by acrolein and BCNU in patients receiving BCNU in 4 split doses with CY was 81%, and it increased to 92% in single dose BCNU regimen. |
86(1,1,1,6) | Details |
| 9698086 | Bunting KD, Townsend AJ: Dependence of aldehyde dehydrogenase-mediated oxazaphosphorine resistance on soluble thiols: importance of thiol interactions with the secondary metabolite acrolein. Biochem Pharmacol. 1998 Jul 1;56(1):31-9. We found that both ALDH isozymes were inhibited by acrolein, with IC50 values of 35 and 144 microM for ALDH-1 or ALDH-3, respectively. |
31(0,1,1,1) | Details |
| 11306050 | Townsend AJ, Leone-Kabler S, Haynes RL, Wu Y, Szweda L, Bunting KD: Selective protection by stably transfected human ALDH3A1 (but not human ALDH1A1) against toxicity of aliphatic aldehydes in V79 cells. Chem Biol Interact. 2001 Jan 30;130-132(1-3):261-73. Neither ALDH1A1 nor ALDH3A1 conferred any protection against acrolein, or chloroacetaldehyde. We have developed transgenic cell lines to examine the potential for either human ALDH1A1 or ALDH3A1 to protect against damage mediated by these toxic aldehydes. |
3(0,0,0,3) | Details |
| 8662658 | Bunting KD, Townsend AJ: De novo expression of transfected human class 1 aldehyde dehydrogenase (ALDH) causes resistance to oxazaphosphorine anti-cancer alkylating agents in hamster V79 cell lines. J Biol Chem. 1996 May 17;271(20):11884-90. Overexpression of class 1 ALDH (ALDH-1) has been observed in cells selected for survival in the presence of OAPs. Transfectants were cross-resistant to other OAPs but not to phosphoramide mustard, ifosfamide mustard, melphalan, or acrolein. |
3(0,0,0,3) | Details |
| 19224214 | Hingorani P, Zhang W, Piperdi S, Pressman L, Lin J, Gorlick R, Kolb EA: Preclinical activity of palifosfamide (ZIO-201) in pediatric sarcomas including oxazaphosphorine-resistant osteosarcoma. Cancer Chemother Pharmacol. 2009 Sep;64(4):733-40. Epub 2009 Feb 18. ALDH1A1 and ALDH3A1 gene expression data for the OS xenografts were mined from the Pediatric Preclinical Testing Program gene expression data. They are pro-drugs and undergo hepatic metabolism into the active moiety and potentially toxic by-products such as acrolein and chloracetaldehyde, which may cause hemorrhagic cystitis and encephalopathy, respectively. |
1(0,0,0,1) | Details |