| Name | lactate dehydrogenase (protein family or complex) |
|---|---|
| Synonyms | LDH; lactate dehydrogenase; lactate dehydrogenases |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18694313 | Cho Y, Shi R, Borgens RB, Ivanisevic A: Functionalized mesoporous nanoparticle-based drug delivery system to rescue acrolein-mediated cell death. Nanomedicine. 2008 Aug;3(4):507-19. Lactate dehydrogenase, MTT, ATP and assays were used to examine the physiological functioning of the samples and the loss of lactate dehydrogenase from the cytoplasm assayed the integrity of the membranes. |
1(0,0,0,1) | Details |
| 10079053 | Arumugam N, Sivakumar V, Thanislass J, Pillai KS, Devaraj SN, Devaraj H: Acute pulmonary toxicity of acrolein in rats--underlying mechanism. . Toxicol Lett. 1999 Feb 22;104(3):189-94. This led to enhanced lipid peroxidation, which produced extensive lung damage as indicated by the elevated levels of the biochemical markers--angiotensin converting enzyme, lactate dehydrogenase, protein and lactate in the bronchoalveolar lavage. |
1(0,0,0,1) | Details |
| 2221083 | Doupnik CA, Leikauf GD: Acrolein stimulates eicosanoid release from bovine airway epithelial cells. Am J Physiol. 1990 Oct;259(4 Pt 1):L222-9. |
0(0,0,0,0) | Details |
| 8397454 | Patel JM, Block ER: Acrolein-induced injury to cultured pulmonary artery endothelial cells. . Toxicol Appl Pharmacol. 1993 Sep;122(1):46-53. |
0(0,0,0,0) | Details |
| 19073213 | Jia Z, Misra BR, Zhu H, Li Y, Misra HP: Upregulation of cellular by 3H-1,2-dithiole-3-thione as a possible treatment strategy for protecting against acrolein-induced neurocytotoxicity. Neurotoxicology. 2009 Jan;30(1):1-9. Epub 2008 Nov 27. Pretreatment of SH-SY5Y cells with 100 microM D3T afforded a dramatic protection against acrolein-induced cytotoxicity, as assessed by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium (MTT) reduction, lactate dehydrogenase release, as well as morphological changes. |
81(1,1,1,1) | Details |
| 17597105 | Yan R, Zu X, Ma J, Liu Z, Adeyanju M, Cao D: Aldo-keto reductase family 1 B10 gene silencing results in growth inhibition of colorectal cancer cells: Implication for cancer intervention. Int J Cancer. 2007 Nov 15;121(10):2301-6. AKR1B10 downregulation enhanced the susceptibility of HCT-8 cells to acrolein (25 microM) and crotonaldehyde (50 microM), resulting in rapid oncotic cell death characterized with lactate dehydrogenase efflux and annexin-V staining. |
6(0,0,1,1) | Details |
| 1577225 | Watanabe M, Sugimoto M, Ito K: The acrolein cytotoxicity and cytoprotective action of in primary cultured rat hepatocytes. Gastroenterol Jpn. 1992 Apr;27(2):199-205. Treatment of hepatocytes with 100 microM acrolein resulted in a marked loss of cellular (GSH) within 15 min, gradual accumulation of cellular lipid peroxide (LPO) and subsequent lactate dehydrogenase (LDH) leakage in the medium from 3 hr after exposure to acrolein. |
6(0,0,1,1) | Details |
| 8360943 | Ramos KS, Thurlow CH: Comparative cytotoxic responses of cultured avian and rodent aortic smooth muscle cells to allylamine. J Toxicol Environ Health. 1993 Sep;40(1):61-76. Challenge with 200 microM acrolein (ACR) for 4 h reduced the GSH content in avian, but not rodent, subcultures of SMCs. Cellular glutathione (GSH) content and lactate dehydrogenase (LDH) leakage were used as indices of cytotoxicity. |
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| 17140783 | Subash Babu P, Prabuseenivasan S, Ignacimuthu S: --a potential antidiabetic agent. Phytomedicine. 2007 Jan;14(1):15-22. Epub 2006 Nov 30. Also restored the altered plasma enzyme (aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, alkaline phosphatase and acid phosphatase) levels to near normal. |
1(0,0,0,1) | Details |
| 3571100 | Ramos K, Cox LR: Primary cultures of rat aortic endothelial and smooth muscle cells: I. In Vitro Cell Dev Biol. 1987 Apr;23(4):288-96. Cultures of both cell types were exposed to acrolein (2, 5 or 50 ppm), an environmental pollutant, for 4 and 24 h. Morphologic damage, lactate dehydrogenase release, and cellular thiol content were used as indices of cytotoxicity. |
1(0,0,0,1) | Details |
| 3755756 | Badr MZ, Belinsky SA, Kauffman FC, Thurman RG: Mechanism of hepatotoxicity to periportal regions of the liver lobule due to allyl role of and lipid peroxidation. J Pharmacol Exp Ther. 1986 Sep;238(3):1138-42. Infusion of allyl in -saturated perfusate in either direction caused release of lactate dehydrogenase and malondialdehyde. |
1(0,0,0,1) | Details |
| 11394714 | Karas M, Chakrabarti SK: potentiation of allyl -induced hepatotoxicity. J Environ Pathol Toxicol Oncol. 2001;20(2):155-64. We examined the effects of (C) on allyl (AA)- and acrolein (A)-induced hepatotoxicity on freshly-isolated, rat hepatocytes obtained from livers of adult, male, Sprague-Dawley rats. The AA (2.5 mM)-induced lactate dehydrogenase (LDH) leakage observed after 60 minutes incubation was completely prevented when pretreated for 15 minutes with 4-methylpyrazole (MP) (0.5 mM). |
1(0,0,0,1) | Details |
| 2842890 | Ramos K, Grossman SL, Cox LR: Allylamine-induced vascular toxicity in vitro: prevention by semicarbazide-sensitive amine oxidase inhibitors. Toxicol Appl Pharmacol. 1988 Aug;95(1):61-71. Single cell suspensions of VEC or SMC formed acrolein (ACR) when incubated in the presence of AAM. Lactate dehydrogenase (LDH) release and morphological alterations were chosen as indicators of cytotoxicity. |
1(0,0,0,1) | Details |
| 2933316 | Belinsky SA, Bradford BU, Forman DT, Glassman EB, Felder MR, Thurman RG: Hepatotoxicity due to allyl in deermice depends on alcohol dehydrogenase. Hepatology. 1985 Nov-Dec;5(6):1179-82. In contrast, dose-dependent necrosis of periportal regions of the liver and increases in plasma levels of lactate dehydrogenase, sorbitol dehydrogenase and SGOT were observed in plasma from alcohol dehydrogenase-positive deermice (AdhF) 24 hr following administration of allyl (21 to 84 mg per kg). Thus, these data demonstrate that metabolism of allyl to acrolein by alcohol dehydrogenase is obligatory for the hepatotoxicity of allyl |
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| 2728003 | Toraason M, Luken ME, Breitenstein M, Krueger JA, Biagini RE: Comparative toxicity of allylamine and acrolein in cultured myocytes and fibroblasts from neonatal rat heart. Toxicology. 1989 May 31;56(1):107-17. Toxicity was assessed by measuring lactate dehydrogenase (LDH) release as an indicator of cell lysis. |
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| 1897958 | Lash LH, Woods EB: Cytotoxicity of alkylating agents in isolated rat kidney proximal tubular and distal tubular cells. Arch Biochem Biophys. 1991 Apr;286(1):46-56. Methyl vinyl ketone and a metabolite of allyl acrolein, are Michael acceptors that bind to cellular protein sulfhydryl groups and GSH. Lactate dehydrogenase leakage was used to assess irreversible cellular injury. |
1(0,0,0,1) | Details |