| Name | cAMP response element binding protein |
|---|---|
| Synonyms | Active transcription factor CREB; CREB; CREB 1; CREB1; cAMP response element binding protein; cAMP response element binding protein 1; cAMP responsive element binding protein 1; cAMP responsive element binding protein 1 isoform B… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16337876 | Pugazhenthi S, Phansalkar K, Audesirk G, West A, Cabell L: Differential regulation of c-jun and CREB by acrolein and Free Radic Biol Med. 2006 Jan 1;40(1):21-34. Epub 2005 Sep 2. Acrolein and 4HNE increased the levels of active phosphorylated forms of c-jun and CREB, the transcription factors that promote apoptosis and cell survival, respectively. |
121(1,2,3,6) | Details |
| 18448814 | Park YS, Taniguchi N: Acrolein induces inflammatory response underlying endothelial dysfunction: a risk factor for atherosclerosis. Ann N Y Acad Sci. 2008 Apr;1126:185-9. Our study demonstrates that acrolein, a known toxin in tobacco smoke, elevates oxidative stress via inactivation of thioredoxin reductase and stimulates expression of cyclooxygenase-2 through activation of the protein kinase C, p38 mitogen-activated protein kinase, and cAMP response element-binding protein pathway in endothelial cells. |
31(0,1,1,1) | Details |