Protein Information

Name alkaline phosphatase
Synonyms ALP 1; Alkaline phosphatase; ALPG; ALPPL; ALPPL 2; ALPPL2; GCAP; Germ cell alkaline phosphatase…

Compound Information

Name acrolein
CAS 2-propenal

Reference List

PubMed Abstract RScore(About this table)
20209193 Pereira ML, Carvalho JC, Peres F, Fernandes MH: Simultaneous effects of nicotine, acrolein, and acetaldehyde on osteogenic-induced bone marrow cells cultured on plasma-sprayed titanium implants. Int J Oral Maxillofac Implants. 2010 Jan-Feb;25(1):112-22.

Results: Acrolein and acetaldehyde caused dose-dependent inhibitory effects at levels similar to and greater than 0.03 and 0.1 mmol/L, respectively; IC50 regarding cell viability/proliferation and alkaline phosphatase was 0.06 mmol/L for acrolein and 0.3 mmol/L for acetaldehyde.
81(1,1,1,1) Details
10092592 Horton ND, Biswal SS, Corrigan LL, Bratta J, Kehrer JP: Acrolein causes inhibitor kappaB-independent decreases in nuclear factor kappaB activation in human lung adenocarcinoma (A549) cells. J Biol Chem. 1999 Apr 2;274(14):9200-6.

Both acrolein and DEM decreased NF-kappaB function approximately 50% at 2 h after treatment with TPA, as shown by a secreted alkaline phosphatase reporter assay.
81(1,1,1,1) Details
7506438 Mohrmann M, Pauli A, Walkenhorst H, Schonfeld B, Brandis M: Effect of ifosfamide metabolites on sodium-dependent phosphate transport in a model of proximal tubular cells (LLC-PK1) in culture. Ren Physiol Biochem. 1993 Nov-Dec;16(6):285-98.

Acrolein also is the only metabolite with a moderate effect on alkaline phosphatase.
81(1,1,1,1) Details
2763206 Hales BF: Effects of phosphoramide mustard and acrolein, cytotoxic metabolites of cyclophosphamide, on mouse limb development in vitro. Teratology. 1989 Jul;40(1):11-20.

Alkaline phosphatase activity was significantly decreased in fore- and hindlimbs exposed to phosphoramide mustard, whereas creatine phosphokinase activity was only reduced in hindlimbs in the limbs exposed to the higher concentration of phosphoramide mustard.
1(0,0,0,1) Details
17140783 Subash Babu P, Prabuseenivasan S, Ignacimuthu S: Cinnamaldehyde--a potential antidiabetic agent. Phytomedicine. 2007 Jan;14(1):15-22. Epub 2006 Nov 30.


Also cinnamaldehyde restored the altered plasma enzyme (aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, alkaline phosphatase and acid phosphatase) levels to near normal.
1(0,0,0,1) Details
15503352 Reddy AM, Seo JH, Ryu SY, Kim YS, Kim YS, Min KR, Kim Y: Cinnamaldehyde and 2-methoxycinnamaldehyde as NF-kappaB inhibitors from Cinnamomum cassia. Planta Med. 2004 Sep;70(9):823-7.


In the present study, an extract from stem bark of Cinnamomum cassia Blume (Lauraceae) was discovered to have an inhibitory effect on LPS-induced NF-KB transcriptional activity, which was determined using macrophages RAW 264.7 transfected stably with an alkaline phosphatase reporter construct containing four copies of the NF-KB binding KB sequence.
1(0,0,0,1) Details
3085586 Margel S, Marcus L: Specific hemoperfusion through agarose acrobeads. Appl Biochem Biotechnol. 1986 Feb;12(1):37-66.

Likewise, a battery of the soluble blood components (Cl-, K+, Na+, Ca2+, PO3/4-), total proteins, albumin, and C'4 component of the complement cascade, as well as the enzymes SGOT, LDH, and alkaline phosphatase, remained constant within narrow limits during the hemoperfusion procedure.
The chemical and physical structure of the beads is stable; neither acrolein nor bead fragments were detected in hemoperfusion trials.
1(0,0,0,1) Details
1282722 Mohrmann M, Pauli A, Ritzer M, Schonfeld B, Seifert B, Brandis M: Inhibition of sodium-dependent transport systems in LLC-PK1 cells by metabolites of ifosfamide. Ren Physiol Biochem. 1992 Nov-Dec;15(6):289-301.


We used the permanent renal epithelial cell line LLC-PK1 in order to investigate whether major metabolites of IF (i.e. 4-OH-IF, acrolein and chloracetyldehyde) induced the transport defects most frequently detected after IF therapy in vivo.
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