Protein Information

Name Nociceptin
Synonyms Nociceptin; Nociceptin precursor; OFQ; Orphanin FQ; PNOC; PPNOC; Prepronociceptin; Propronociceptin…

Compound Information

Name chloralose
CAS

Reference List

PubMed Abstract RScore(About this table)
11011815 Armstead WM: Role of nociceptin/orphanin FQ in age-dependent cerebral hemodynamic effects of brain injury. J Neurotrauma. 2000 Sep;17(9):751-64.

This study was designed to compare the role of the newly described endogenous opioid nociceptin/orphanin FQ (NOC/oFQ) in the reductions of cerebral blood flow (CBF) and pial artery diameter observed following fluid percussion brain injury (FPI) in chloralose anesthetized newborn and juvenile pigs as a function of time postinsult.
32(0,1,1,2) Details
15707012 Maslov LN, Krylatov AV, Lishmanov IuB, Galo G, Ma K, Stakheev DL: [The mechanism of antiarrhythmic action of the endogenous ORL1 receptor agonist nociceptin]. Eksp Klin Farmakol. 2004 Nov-Dec;67(6):32-5.

Prophylactic intravenous (i.v.) injections of a selective agonist of ORL1 receptors nociceptin (orphanin FQ) in a dose of 0.4 mg/kg prevented the development of aconitine-induced arrhythmia in rats narcotized with diethyl ether or chloralose.
35(0,1,1,5) Details
10350539 Chu X, Xu N, Li P, Mao L, Wang JQ: Inhibition of cardiovascular activity following microinjection of novel opioid-like neuropeptide nociceptin (orphanin FQ) into the rat rostral ventrolateral medulla. Brain Res. 1999 May 22;829(1-2):134-42.

In this study, centrally mediated cardiovascular actions of this peptide were investigated in the alpha-chloralose/urethane-anesthetized rats.
7(0,0,0,7) Details
15649868 Crisostomo MM, Li P, Tjen-A-Looi SC, Longhurst JC: Nociceptin in rVLM mediates electroacupuncture inhibition of cardiovascular reflex excitatory response in rats. J Appl Physiol. 2005 Jun;98(6):2056-63. Epub 2005 Jan 13.

Blood pressure in ventilated male Sprague-Dawley rats (400-600 g) anesthetized by ketamine and alpha-chloralose was measured during balloon inflation of the stomach.
4(0,0,0,4) Details