Protein Information

Name ACPD
Synonyms ACPD; CPD; Cupidin; HOMER 2; HOMER 2A; HOMER 2B; HOMER2; HOMER2A…

Compound Information

Name chloralose
CAS

Reference List

PubMed Abstract RScore(About this table)
8594025 Li A, Nattie EE: Prolonged stimulation of respiration by brain stem metabotropic glutamate receptors. J Appl Physiol. 1995 Nov;79(5):1650-6.

Stimulation of metabotropic glutamate receptors (mGluRs) in the retrotrapezoid nucleus (RTN) of chloralose-urethan-anesthetized rats by the mGluR agonist (1S,3R)-aminocyclopentanedicarboxylic acid [(1S,3R)-ACPD; 10 nl, 1 mM] increases integrated phrenic nerve amplitude (PNA) for > 60 min.
82(1,1,1,2) Details
15020305 Chianca DA Jr, Lin LH, Dragon DN, Talman WT: NMDA receptors in nucleus tractus solitarii are linked to soluble guanylate cyclase. Am J Physiol Heart Circ Physiol. 2004 Apr;286(4):H1521-7.

In adult male Sprague-Dawley rats anesthetized with chloralose, the ionotropic receptor agonists N-methyl-d-aspartate (NMDA) and dl-alpha-amino-3-hydroxy-5-methylisoxazole-propionic acid (AMPA) and the metabotropic receptor agonist trans-dl-amino-1,3-cyclopentane-dicarboxylic acid (ACPD) were microinjected into the NTS before and after microinjection of sGC inhibitors at the same site.
81(1,1,1,1) Details
9698812 Machado BH, Bonagamba LG: Cardiovascular responses to microinjection of trans-(+/-)-ACPD into the NTS were similar in conscious and chloralose-anesthetized rats. Braz J Med Biol Res. 1998 Apr;31(4):573-9.

The responses obtained with trans-(+/-)-ACPD were compared with the responses to L-glutamate (1 nmol/100 nl), since in a previous study we showed that anesthesia converted a pressor response to L-glutamate microinjected into the NTS of conscious rats to a depressor response in the same rats under urethane or chloralose anesthesia.
44(0,1,3,4) Details